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Method for rapidly screening 17 organic antibacterial agents in paper products for daily use

An organic antibacterial agent and tissue paper technology, which is applied in the field of paper product quality and safety testing, can solve problems such as high cost and low efficiency, and achieve the effect of avoiding inaccuracy and improving screening sensitivity.

Active Publication Date: 2021-08-06
GUANGDONG TESTING INST OF PROD QUALITY SUPERVISION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of organic antibacterial agents that may be added to household paper products. If each type of antibacterial agent is tested, there are shortcomings such as low efficiency and high cost. However, for benzimidazoles and quaternary ammonium salts (such as benzalkonium chloride) etc.), isothiazolinones and other organic antimicrobials have not been reported in the literature for high-throughput simultaneous rapid screening

Method used

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  • Method for rapidly screening 17 organic antibacterial agents in paper products for daily use
  • Method for rapidly screening 17 organic antibacterial agents in paper products for daily use
  • Method for rapidly screening 17 organic antibacterial agents in paper products for daily use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] This embodiment provides a rapid screening method for 17 kinds of organic antibacterial agents in paper products of food contact materials, including the following steps:

[0062] 1. Preprocessing steps

[0063] 1.1 Extraction

[0064] Take food contact materials such as paper cups and kitchen absorbent paper and cut them into pieces of about 5mm×5mm in size, mix them well, weigh 2g (accurate to 0.01g) and put them in a conical flask, add 15mL of water and 15mL of acetonitrile, shake well and place in ultrasonic Sonicate in a washing machine at a frequency of 50 kHz in a 40°C water bath for 30 minutes, take out the Erlenmeyer flask, cool to room temperature, filter with suction, transfer the filtrate to a 50 mL plastic centrifuge tube a, and transfer the remaining paper product samples to centrifuge tube b for later use. Add 6 g of anhydrous magnesium sulfate and 5 g of ammonium sulfate to centrifuge tube a, vortex extract at 1800 r / min for 10 min with an automatic vor...

Embodiment 2

[0088] Wet wipes of paper products that come into contact with the human body are used as the test object, including wet wipes that contain organic antibacterial agents and those that do not contain organic antibacterial agents on the product label.

[0089] 1. Preprocessing steps. Taking household paper product wet tissue as the test object, cut the sample to about 5mm×5mm in size and mix well. All the other extraction steps and purification steps are the same as in Example 1.

[0090] 2. The preparation of the standard solution is the same as in Example 1.

[0091] 3. The detection conditions of the instrument are the same as in Example 1.

[0092] 4. Result analysis:

[0093] A total of 10 batches of samples were tested, including the screening results of product labels expressly containing organic antimicrobial agents (5 batches) and not containing organic antimicrobial agents (5 batches) are listed in Table 2 below.

[0094] The corresponding organic antibacterial age...

Embodiment 3

[0099] In this embodiment, the detection objects are paper diapers (diapers) and sanitary napkins, which are paper products that come into contact with the human body.

[0100] 1. Preprocessing steps. Taking paper diapers (diapers) and sanitary napkins as the test objects, take the top layer of paper diapers (diapers) and sanitary napkins, cut them into pieces and mix them evenly. All the other extraction steps and purification steps are the same as in Example 1.

[0101] 2. The preparation of the standard solution is the same as in Example 1.

[0102] 3. The detection conditions of the instrument are the same as in Example 1.

[0103] 4. Result analysis:

[0104] A total of 10 batches of diapers (diapers) and sanitary napkins were tested, and no organic antibacterial agents were detected. It may be that these products are disinfected in other ways.

[0105] Image 6 It is the total ion chromatogram (TIC) of the paper diaper (diaper) sample.

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Abstract

The invention discloses a method for rapidly screening 17 organic antibacterial agents in a paper product for daily use. The method comprises the steps of by taking the paper product for daily use as a research object and an acetonitrile aqueous solution as an extracting agent, heating in a water bath, carrying out ultrasonic extraction, salting out anhydrous magnesium sulfate and ammonium sulfate, degreasing acetonitrile-saturated n-hexane, purifying by using a mixed purification column of anhydrous sodium sulfate and graphitized carbon black, carrying out rotary evaporation and concentration to dryness, redissolving by using a methanol aqueous solution, and screening by using UPLC / MS-IT-TOF. An ion trap-time-of-flight mass spectrum screening database of 17 organic antibacterial agents in the paper product for daily use is established, mass spectrum fracture characteristics and m / z accurate mass numbers of MS1 and MS2 are obtained, and a quasi-targeted screening technology is formed to quickly screen and accurately identify the 17 organic antibacterial agents in the paper product for daily use under the condition of no standard substance (reference substance).

Description

technical field [0001] The invention belongs to the technical field of paper product quality and safety detection, in particular to a rapid screening method for 17 kinds of organic antibacterial agents in household paper products, especially a kind of 17 kinds of organic antibacterial agents in food contact paper products and human body contact paper products rapid drug screening method. Background technique [0002] Household paper products are inseparable from our lives. They come into close contact with our skin or directly contact our food. These paper products often use organic antibacterial agents to prevent mildew during production, processing and storage, to inhibit and kill bacteria and mold. , algae, etc., to achieve antiseptic and antibacterial effects, and increase the storage and service life of paper products. Commonly used organic antibacterial agents include benzimidazoles, quaternary ammonium salts (such as benzalkonium chloride, etc.), isothiazolinones, et...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/12G01N30/14G01N30/30G01N30/32G01N30/34G01N30/72
CPCG01N30/02G01N30/06G01N30/12G01N30/14G01N30/30G01N30/32G01N30/34G01N30/72G01N2030/062G01N2030/324Y02A50/30
Inventor 綦艳李锦清李聪陈满英
Owner GUANGDONG TESTING INST OF PROD QUALITY SUPERVISION
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