Vietnamese sophora root flavonoid pharmaceutical composition for treating viral pneumonia

A technology of viral pneumonia and composition, which is applied in the field of drug preparation, can solve problems such as side effects, and achieve the effects of inhibiting secretion, promoting secretion, and low viscosity

Inactive Publication Date: 2021-08-10
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main viruses that cause viral pneumonia include viral pneumonia virus, respiratory syncytial virus paraviral pneumonia virus, etc. In the prior art, antibiotics have been used for a long time for treatment, but it is easy to cause side effects or secondary diseases such as chickenpox and measles virus. Pneumonia, etc.

Method used

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  • Vietnamese sophora root flavonoid pharmaceutical composition for treating viral pneumonia
  • Vietnamese sophora root flavonoid pharmaceutical composition for treating viral pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pharmaceutical composition, comprising: 100 parts of flavonoid extracts from bean root, 5 parts of baicalein, 5 parts of palmetine, and 5 parts of geniposide;

[0023] Wherein, the flavonoids extract of bean root adopts conventional reflux extraction method, and is prepared as follows:

[0024] Weigh 5 g of mountain bean root powder, add 80 mL of 70% ethanol, heat and reflux for extraction for 2 hours, then filter, and take the filtrate to obtain the extract; pass the extract through a 0.45 μm filter membrane, elute, and concentrate the eluate by rotary evaporation to obtain Soba root flavonoids extract; the elution process is specifically, use the pretreated D101 macroporous resin to load the sample, after the adsorption equilibrium, first deionized water elution and then 90% ethanol elution, after obtaining the eluent, in Rotary evaporation at 45°C followed by concentration; the volume ratio of the resin bed volume, the deionized water, and the 90% ethanol is 1:3:8;...

Embodiment 2

[0027] A pharmaceutical composition, comprising: 100 parts of flavonoid extracts from bean root, 10 parts of baicalein, 10 parts of palmetine, and 10 parts of geniposide;

[0028] Wherein, the flavonoids extract of bean root adopts ultrasonic extraction method, and is prepared as follows:

[0029] Weigh 5 g of mountain bean root powder, put it in an ultrasonic instrument, add 80 mL of 70% ethanol, and filter it after ultrasonic extraction for 30 minutes, and the filtrate is the extract; pass the extract through a 0.45 μm filter membrane, elute, and eluate Concentrate by rotary evaporation to obtain the flavonoids extract of bean root; the elution process is specifically, use the pretreated D101 macroporous resin to load the sample, after the adsorption equilibrium, first elute with deionized water and then with 90% ethanol to obtain The eluate was then concentrated by rotary evaporation at 45°C; the volume ratio of the resin bed volume, the deionized water, and the 90% ethanol...

Embodiment 3

[0032] A pharmaceutical composition, comprising: 100 parts of flavonoid extracts from bean root, 8 parts of baicalein, 8 parts of palmitate, and 6 parts of geniposide;

[0033] Wherein, the flavonoids extract of bean root is prepared as follows:

[0034] S1. Take the root slices of the mountain bean root and crush them through a 40-mesh sieve and soak them in ethanol with a volume fraction of 65% for 20 hours. After suction filtration, take the filter residue and dry it at 90° C. for 18 hours to obtain the root root of the mountain root;

[0035] S2. Add the root powder and enzyme to the extraction solvent in turn, stir evenly, react at 35°C for 40 minutes, and then filter to obtain the enzymolysis solution and residue; the root powder, the enzyme, the extraction The weight ratio of the solvent is 100:1.2:450, the enzyme is cellulase or pectinase; the extraction solvent is ethanol with a volume fraction of 70%;

[0036] S3. Put the enzymolysis residue in S2 in the extraction ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition, and the composition is prepared from 100 parts of radix sophorae tonkinensis flavonoid extracts, 5 to 10 parts of baicalin, 5 to 10 parts of fibrauretine and 5 to 10 parts of geniposide. The invention also discloses application of the pharmaceutical composition in preparation of drugs for treating viral pneumonia, the pharmaceutical composition can inhibit secretion of inflammatory factors TNF-alpha and IL-6 on one hand, and can promote secretion of an antiviral factor IFN-gamma on the other hand, so inflammatory injury is finally reduced, and lung tissue injury caused by virus infection is relieved; when the addition amount of the pharmaceutical composition is not less than 5mg/kg.d, the treatment effect is better, and a new idea is provided for the treatment of viral pneumonia.

Description

technical field [0001] The invention relates to the field of medicine preparation. More specifically, the present invention relates to a kind of flavonoid pharmaceutical composition of bean root for the preparation of treatment of viral pneumonia. Background technique [0002] Viral pneumonia is an inflammation of the upper respiratory tract that spreads downward to the lower respiratory tract until the bronchi and lungs are infected by a virus. The main viruses that cause viral pneumonia include viral pneumonia virus, respiratory syncytial virus paraviral pneumonia virus, etc. In the prior art, antibiotics have been used for a long time for treatment, but it is easy to cause side effects or secondary diseases such as chickenpox and measles virus. Pneumonia, etc. At present, viral pneumonia is always a refractory emergency and critical disease. Therefore, there is an urgent need for a drug that can effectively treat viral pneumonia. Contents of the invention [0003] An...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P11/00A61P31/12A61P31/14A61K31/4375A61K31/7048
CPCA61K31/4375A61K31/7048A61K36/489A61K2236/19A61K2236/333A61P11/00A61P31/12A61P31/14A61K2300/00
Inventor 王硕龚小妹莫单丹欧春丽周小雷缪剑华
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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