Unlock instant, AI-driven research and patent intelligence for your innovation.

Controllable crosslinking and degrading material and application thereof

A technology of synthetic materials and molecules, which is applied in the fields of application, medical science, and pharmaceutical formulations, can solve the problems of no interaction between tissues, low strength of colloids, and inconvenient use, and achieve strong hemostasis ability, overcome insufficient water absorption, Meet the effect of pressing to stop bleeding

Active Publication Date: 2021-08-24
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the jelly formed by the hemostatic powder is not strong enough and is easily broken under the impact of the blood flow at the wound; the hemostatic powder does not interact with the tissue at the wound, and must be specially fixed during use, resulting in inconvenient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Controllable crosslinking and degrading material and application thereof
  • Controllable crosslinking and degrading material and application thereof
  • Controllable crosslinking and degrading material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0041] Preparation of materials:

[0042] 1. The preparation method of four-arm oxyethylene polyoxypropylene polyoxyethylene succinimide ester

[0043] Four-armed oxyethylene polyoxypropylene polyoxyethylene (0.60 mmol) was dissolved in 30 mL of anhydrous dioxane. N,N'disuccinimide ester (12.0mmol) was dissolved in 20mL of anhydrous acetone, and added slowly under magnetic stirring. 12.0 mmol of 4-(dimethylamino)pyridine was dissolved in 20 mL of anhydrous acetone, and added slowly under magnetic stirring. After activation at room temperature for 6 hours, four-arm oxyethylene polyoxypropylene polyoxyethylene precipitates were obtained. [1]

[0044] 2. The preparation method of four-arm polyoxyethylene polyoxypropylene polyoxyethylene succinimide ester

[0045] Four-armed oxyethylene polyoxypropylene polyoxyethylene (0.60 mmol) was dissolved in 30 mL of anhydrous dioxane. N,N'disuccinimide ester (12.0mmol) was dissolved in 20mL of anhydrous acetone, and added slowly under ma...

Embodiment 1

[0052] Weigh 130mg four-arm oxyethylene polyoxypropylene polyoxyethylene succinimide ester (compound as shown in formula I, wherein, m is 56, n is 23, p is 11, x is 4, R 1 Amino) was dissolved in 1ml of normal saline to obtain solution 1 (mass-volume concentration of 130mg / ml), and 130mg of four-arm polyethylene glycol amino (as shown in formula VI, wherein m was 56, x was 4, R 2 Amino) was dissolved in 1ml of normal saline to obtain solution 2 (mass-volume concentration was 130mg / ml); use one of the double-barreled syringes to draw a mixed solution, then inject it into a cylindrical glass mold, and take it out after 30min , Use a universal tensile machine to measure the compressive strength, the strength can reach 3.2MPa, and the strength is high.

[0053] Degradation test: Prepare a cylindrical gel with a diameter of 1cm and a height of 1cm according to the above method, put the gel into a closed container with PBS buffer solution, and then put it in a constant temperature ...

Embodiment 2

[0058] Take by weighing 200mg four-arm polyacrylamide (as shown in formula II, wherein, m is 112, R 1 Amino) was dissolved in 1ml PBS solution to obtain solution 1 (mass-volume concentration is 200mg / ml), weighed 200mg four-arm polyoxyethylene polyoxypropylene polyoxyethylene succinimide ester (as shown in formula IV, where , m is 11, n is 112, p is 2, and x is 4) be dissolved in 1ml PBS to obtain solution 2 (mass-volume concentration is 200mg / ml); Then pour into the transparent sample bottle at the same time, invert the sample bottle, and the time when the liquid does not flow is the gelation time. The gel time of the system is 5s, the gelation speed is fast, and it can be quickly formed on the surface of the object.

[0059] The degradation performance of the hydrogel prepared in this example was tested according to the method in Example 1, and the degradation time was measured to be 3 days.

[0060] Combine this gel and Mestel quick-acting hemostatic powder to form a comp...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
Login to View More

Abstract

The invention provides a controllable crosslinking and degrading material and the application thereof. A composite hemostatic system is formed by mixing synthetic molecules 1, synthetic molecules 2 and hemostatic powder, the synthetic molecules 1 and the synthetic molecules 2 can react with each other in a water solution to form gel, when the composite hemostatic system is used, the water absorption powder can absorb a large amount of water, and the defect that the gel and the powder are washed away during large-region bleeding can be avoided by gel coating; The adhesion caused by direct contact between the wound and the tissue is avoided. The gel has relatively high strength and interaction capacity with tissues. Meanwhile, the degradation time can be adjusted so as to be suitable for different bleeding positions and bleeding degrees.

Description

technical field [0001] The invention relates to a synthetic material, in particular to a controllable cross-linking and degradable synthetic material and its application in a hemostatic system. Background technique [0002] For a long time, traditional methods of hemostasis such as ligation, suture, electrocoagulation, absorbable hemostatic clips and tourniquets not only increase the difficulty of surgery for medical workers, but also affect the surgical field of vision and cause hidden dangers of medical accidents. In recent years, various materials have been developed for the hemostatic seal, including hemostatic powder, hemostatic gel, hemostatic bandage, and so on. For hemostatic gel, it is difficult to apply the gel on the surface of the wound under the washing of a large blood flow, which seriously limits their application; for the hemostatic bandage, it cannot be applied to irregularly shaped wounds, and cannot seal deep wounds. Hemostasis of layered wounds. In comp...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/06A61L24/08A61L24/10A61L24/02A61L24/00
CPCA61L24/043A61L24/046A61L24/06A61L24/08A61L24/10A61L24/02A61L24/0031A61L24/0042A61L2400/04C08L33/02C08L71/02
Inventor 吴德成潘正叶慧君
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA