Feather keratin/sodium alginate microgel drug loading system, and preparation method and application thereof
A technology of feather keratin and sodium alginate, which is applied in the direction of pharmaceutical formulations, drug combinations, antineoplastic drugs, etc., can solve the problems of low drug loading and high drug leakage rate, and achieve high drug loading and drug leakage rate. Low, the effect of improving the utilization rate
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[0023] The present invention provides a method of preparing a feather-based keratin / alginate microgel mass, including the following steps:
[0024] (1) Crosslinking of the feathers and sodium alginate is mixed to obtain a microgel; the mass ratio of the feather keratin and sodium alginate in the feathers of the feathers is 1: (0.3) ~ 12);
[0025] (2) The microgel obtained by the step (1) and the anti-cancer drug solution is mixed for the load treatment, and then the oxidation reaction is mixed with the hydrogen peroxide solution to obtain a feather keratin / alginate microgel massage system. .
[0026] In the present invention, if there is no special instruction, the raw materials employed are conventionally commercially available products in the art.
[0027] In the present invention, if there is no special description, the performed operation is room temperature condition.
[0028] The present invention enters the feathers and sodium alginate to obtain a microgel. In the pres...
Embodiment 1
[0063] First, the preparation method of the feather keratin alkaline solution:
[0064] (1) Extraction process of feather corner protein stock:
[0065] (a) 2 g of the feathers of 2G chicken were washed, dried, and cut, resulting in a crushing, and then mixed with 120 min and 120 min, respectively, in a hydrochloric acid solution of 400 ml of anhydrous ethanol and 40 ° C 200 ml of 0.15 mol / L, Then the filtration was carried out in case, washed with deionized water to wash liquid, and the pretreatment feathers were obtained after drying;
[0066] (b) Preprogenced feathers, deionized water, trimethylmethylmethhane, sodium deionized water, sodium trimethylmethylmethhane, dodecyl sulphate, urea, 2-mercaptoethanol mixed, N 2 The stirring reaction was carried out in an atmosphere, then filtered, and then the filtrate was dialyzed with deionized water for 3 days by a dialysis bag having a molecular weight of 3.5 kDa to obtain a feather hornylacothoric; wherein the mass of the pretreatm...
Embodiment 2
[0080] According to the method of Example 1, the micro-suggesting system of the feather keratin / alginate, wherein the mass ratio of the feather keratin and sodium alginate in the feathers of the feathers is 1: 3; The mass ratio of the anti-cancer pharmaceutical polymethranes in the feather hornyin in the abiotic solution of the feather horny is 3: 1, and the feathers prepared in Example 2 were detected in the same manner as in Example 1. The particle size of the keratin / alginate microgel massage system (i.e., the release rate of doxorubicin in the release of the pH is 7.4 + 10 μm GSH), the specific results are shown in Table 1 .
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