Protamine-PDRN complex, composition and application thereof in preparation of skincare products

A technology of PDRN and protamine, applied in the field of functional skin care products, can solve the problems of reducing curative effect, prone to allergies, cumbersome steps, etc., and achieve the effect of enhancing transdermal absorption effect, improving bioavailability, and clear active ingredients

Active Publication Date: 2021-09-03
润辉生物技术(威海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, products with skin care effects such as oil control, pore shrinkage, acne treatment, and scar repair include traditional Chinese medicine / plant extracts, antibiotics, and chemically synthesized small molecules. The raw material preparation method is to inject DNA molecules into the skin through a gene gun (Bio-Jet molecular atomizer). However, this method needs to be completed in a professional institution, which limits its scope of application; Plant extract; patent CN110269898A uses salicylic acid, clindamycin
Among them, traditional Chinese medicine products add a variety of plant extracts, the active ingredient structure is not clear, the chemical composition is complex, the active ingredient content is low, the mechanism of action is not clear, and the steps of extracting active ingredients from plants are relatively cumbersome, the content and function of active ingredients The effect is easily affected by different origins and sources of different years; oral administration of zinc sulfate or zinc gluconate is likely to cause gastrointestinal irritation, nausea, vomiting and constipation and other adverse reactions; long-term use of antibiotic ingredients is likely to lead to bacterial resistance and reduce the curative effect , the therapeutic effect cannot be achieved; and some products are prone to side effects such as allergies due to differences in skin sensitivity between individuals

Method used

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  • Protamine-PDRN complex, composition and application thereof in preparation of skincare products
  • Protamine-PDRN complex, composition and application thereof in preparation of skincare products
  • Protamine-PDRN complex, composition and application thereof in preparation of skincare products

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Experimental program
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Effect test

Embodiment 1

[0052] The construction of embodiment 1 protamine-PDRN complex

[0053] (1) First, mix 20mg / L protamine solution and 20mg / L PDRN solution according to the N / P ratio of 1.5:1, and stir at room temperature for 1h; (2) then let the mixture stand at room temperature for 1h; (3 ) Finally, the mixture was freeze-dried to obtain the protamine-PDRN complex.

Embodiment 2

[0054] The construction of embodiment 2 protamine-PDRN complex

[0055] (1) First, mix 20mg / L protamine solution and 20mg / L PDRN solution according to the N / P ratio of 2.0:1, and stir at room temperature for 1h; (2) Then let the mixture stand at room temperature for 1h; (3 ) Finally, the mixture was freeze-dried to obtain the protamine-PDRN complex.

Embodiment 3

[0056] Example 3 Construction of protamine-PDRN complex

[0057] (1) First, mix 20mg / L protamine solution and 20mg / L PDRN solution according to the N / P ratio of 2.5:1, and stir at room temperature for 1h; (2) Then let the mixture stand at room temperature for 1h; (3 ) Finally, the mixture was freeze-dried to obtain the protamine-PDRN complex.

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PUM

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Abstract

The invention particularly relates to a protamine-PDRN complex, a composition and application thereof in preparation of skincare products. The protamine-PDRN complex provided by the invention has the effect of inhibiting growth of propionibacterium acnes. The invention further provides a product for treating acnes and acne marks based on the protamine-PDRN complex. The product comprises the protamine-PDRN complex, an effect polypeptide and other matrix ingredients. The product is applied to human skin, has good oil controlling, acne treating, acne mark improving and whitening effects and can be used for fundamentally nourishing skin cells and improving a metabolic level of the skin cells. The product is safe to human and free of toxic or side effects and has extremely high biological safety. Simultaneously, the invention provides preparation and application methods for the product.

Description

technical field [0001] The invention belongs to the technical field of functional skin care products, and in particular relates to a protamine-PDRN complex, a composition and an application in preparing skin care products. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Acne, also known as pimples or pimples, is a common chronic inflammatory skin disease that occurs in oily skin and teenagers aged 13 to 24 years. Thickness, scarring, and hyperpigmentation seriously affect the external image, self-confidence and social activities of teenagers, causing unnecessary psychological burden. Nowadays, with the change of diet structure and lifestyle, the mental stress caused by t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/60A61P17/10A61P31/04A61Q17/00A61Q19/00
CPCA61K8/64A61K8/606A61Q19/00A61Q17/005A61P17/10A61P31/04
Inventor 姬胜利王盈盈殷金岗
Owner 润辉生物技术(威海)有限公司
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