Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tissue engineering bone for repairing cleft palate defect of maxillofacial region and preparation method

A tissue-engineered bone and cleft palate technology, applied in metal processing equipment, additive manufacturing, manufacturing tools, etc., can solve problems such as less development, and achieve the effect of promoting new bone formation, bone regeneration, and good biomechanical conduction.

Inactive Publication Date: 2021-09-07
ZHEJIANG UNIV
View PDF10 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The rapid development of tissue engineering has provided new ideas for the repair and reconstruction of cleft palate. However, due to the specific anatomical structure and biomechanical conduction under physiological conditions in the oral and maxillofacial region, the current tissue engineering bone for cleft palate defect less developed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tissue engineering bone for repairing cleft palate defect of maxillofacial region and preparation method
  • Tissue engineering bone for repairing cleft palate defect of maxillofacial region and preparation method
  • Tissue engineering bone for repairing cleft palate defect of maxillofacial region and preparation method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] A method for preparing a double-layer degradable tissue engineered bone for repairing maxillofacial cleft palate defects, comprising the following steps:

[0033] S1. Process the CT scan image of the jaw of the cleft palate patient, reconstruct the jaw defect model on the affected side, and design the hard palate bionic tissue scaffold according to the jaw defect;

[0034] S2. Integrated printing of β-tricalcium phosphate double-layer scaffolds through light-curing 3D printing (DLP) technology;

[0035] S3. After perfusing the hydrogel premix as claimed in claim 3 in the bracket, it is cured by ultraviolet light to obtain a double-layer degradable tissue engineered bone for repairing maxillofacial cleft palate defect.

[0036] Step S2 is to suspend the β-tricalcium phosphate powder in an organic matrix composed of acrylate and methacrylate, phenyl-2,4,6-trimethylbenzoylphosphonate lithium (free radical photoinitiator) in spare. Input the designed double-layer porous s...

Embodiment 1

[0038] Such as figure 1 As shown, this embodiment provides a double-layer degradable tissue-engineered bone structure for the repair of maxillofacial cleft palate defects, including a double-layer porous scaffold 1 and a pore structure 2 perfused with hydrogel; the basic scaffold According to the shape design of the hard palate, the β-tricalcium phosphate material is integrated printed by light-curing 3D printing (DLP) technology, which is used to restore the shape of the jaw defect and ensure the mechanical strength. The material is degradable and does not affect the normal growth and development of the bone. ; The hydrogel is composed of methyl methacrylate hydrogel (GelMA) modified by deferoxamine (DFO), which has the effect of promoting angiogenesis and bone regeneration.

Embodiment 2

[0040] A method for preparing a double-layer degradable tissue-engineered bone for the repair of maxillofacial cleft palate defect according to Example 1 is provided, and the specific method includes the following steps:

[0041] Step 1: Import the image parameters of palate anatomy obtained from CT scan into the computer Mimics15.01 software, and use GeomagicStudio2013 software to segment the data of normal compact bone and internal cancellous bone trabeculae near the palate defect;

[0042] Step 2: Design the double-layer pore structure of the tissue engineering bone scaffold to fill the palate defect. The upper layer 3 of the double-layer porous scaffold has a pore size of 450 microns, which is similar to the structure of human trabecular bone, which is conducive to bone regeneration; the lower layer 4 of the double-layer porous scaffold In contact with soft tissue, it is designed as a relatively dense layer with a pore size of 50 microns to prevent early growth of epithelia...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a tissue engineering bone for repairing a cleft palate defect of a maxillofacial region and a preparation method. The tissue engineering bone comprises a double-layer porous scaffold and hydrogel, wherein pores of the scaffold are filled with the hydrogel. The double-layer degradable tissue engineering bone prepared by the preparation method is completely matched with the cleft palate defect of a patient, and can accurately restore the original palate structure and function of the patient, so that a series of problems such as donor site trauma, malformation, scars and pain caused by current autogenous bone transplantation and inevitable defects such as limited sources are avoided; and meanwhile, the tissue engineering bone is degradable, so that normal growth and development of the jaw bone are not affected.

Description

technical field [0001] The invention belongs to the technical field of oral medical devices, in particular to a tissue-engineered bone for repairing maxillofacial cleft palate defects and a preparation method thereof. Background technique [0002] Cleft palate is a common congenital malformation of the oral and maxillofacial region of newborns. It not only affects the appearance of the patient, but also affects the shape and function of multiple organs in the patient's oral and maxillofacial region, including appearance deformity, maxillofacial developmental deformity, dental and maxillofacial system deformity and speech function. Impairment, hearing impairment, psychological disorder, etc. are diseases that seriously endanger the physical and mental health of children. [0003] Due to the complex anatomical and physiological environment of the oral and maxillofacial region, the repair of defects caused by cleft palate has always been a difficult problem in stomatology. The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/2803A61F2002/30769A61F2002/30985A61F2310/00293
Inventor 叶冠琛俞梦飞余晓雯李琦赵飞亚叶鑫陆科杰王慧明
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com