10 results about "Cleft palates" patented technology

The invention discloses application of a porphyromonas gingivalis extract in preparation of products related to an embryo cleft palate model, relates to the technical field of molecular biology, and particularly discloses application of the porphyromonas gingivalis extract in construction of the embryo cleft palate model. The research finds that in the embryonic development period, after a porphyromonas gingivalis extract is applied to a parent body by simulating the condition that a periodontitis patient is infected with the porphyromonas gingivalis, a certain probability of cleft palate of an embryo can be caused, and then the application of the porphyromonas gingivalis to construction of related products of an embryo cleft palate model is provided. The invention provides a novel method for constructing a cleft palate embryo, the application field of the porphyromonas gingivalis is expanded, the research on periodontal diseases and systemic toxic and side effects caused by oral infection of the porphyromonas gingivalis is deepened, and a theoretical basis is provided for the occurrence and prevention research of offspring cleft palate of maternal periodontitis patients.

This utility model discloses a breastfeeding device specifically designed for babies with cleft lip and palate. The device includes a nipple body composed of an end connector and a lower connector, which are integrally molded. The length of the nipple body is defined as α, with a length of 110mm ≤ α ≤ 130mm. The end connector of the nipple body has a milk-suction groove and a soothing component for comforting the baby. The lower connector of the nipple body has an anti-colic component to prevent gas. An annular valve is located inside the nipple body. This utility model, with its elongated nipple body, facilitates breastfeeding for babies with cleft lip and palate. Its length exceeds that of ordinary nipples, allowing it to extend beyond the cleft palate and directly contact the tongue, thus facilitating sucking and preventing malnutrition caused by the cleft lip and palate, and protecting the baby's normal development and health.

The invention relates to the technical field of molecular biology, and particularly discloses application of a bifidobacterium adolescentis extract in preventing or reversing cleft palate of embryos. Research finds that in the embryonic development period, after oral administration of the bifidobacterium adolescentis extract to a maternal body, the occurrence of the embryonic cleft palate can be prevented or reversed, and then the application of the bifidobacterium adolescentis extract in preparation of related products for preventing or reversing the embryonic cleft palate is provided. The invention provides a novel method for preventing or reversing embryo cleft palate, the application field of bifidobacterium adolescentis is expanded, and a theoretical basis is provided for preventing or treating offspring cleft palate by using medicines in the maternal pregnancy period.

The invention relates to the technical field of molecular biology, and particularly discloses application of a bifidobacterium adolescentis extract in preventing or reversing cleft palate of embryos. Research finds that in the embryonic development period, after oral administration of the bifidobacterium adolescentis extract to a maternal body, the occurrence of the embryonic cleft palate can be prevented or reversed, and then the application of the bifidobacterium adolescentis extract in preparation of related products for preventing or reversing the embryonic cleft palate is provided. The invention provides a novel method for preventing or reversing embryo cleft palate, the application field of bifidobacterium adolescentis is expanded, and a theoretical basis is provided for preventing or treating offspring cleft palate by using medicines in the maternal pregnancy period.

Embodiments disclosed herein provide a prosthetic device (100) for assisting an individual with cleft lip and cleft palate conditions The prosthetic device includes a flap (101) and a strap (102). The flap (101) includes a lip philtrum prosthetic area (104) connected to a palate prosthetic area (105). The lip philtrum prosthetic area (104) configured as a temporary upper lip prosthetic, and the palate prosthetic area (105) is configured as a temporary palate prosthetic. The strap (102) is connected to the lip philtrum prosthetic area (104) of the flap (101), wherein the strap (102) has a pair of slots (107) positioned at opposite ends of the strap (102). The prosthetic device (100), when secured on a face of the individual, enables the individual to form a complete seal around a feeding implement, thereby facilitating a feeding process.

The utility model relates to the field of medicine feeders, and discloses a novel cleft lip and palate infant medicine feeder which comprises an injection tube used for loading and injecting medicine; the medicine feeding tube is installed at the injection end of the injection tube, the end, away from the injection tube, of the medicine feeding tube is of an arc-shaped structure, so that the medicine feeding tube can enter the oral cavity from the mouth corner of the patient, and the arc-shaped part is tightly attached to the cheek of the patient. According to the cleft lip and palate medicine feeder, the medicine feeder is more suitable for a cleft lip and palate infant, the arc-shaped structure of the medicine feeding pipe and the auxiliary plate are arranged, it is ensured that the medicine feeder cannot make contact with a wound of a patient in the medicine feeding process, pain and discomfort of the patient are relieved, the liquid outlet limits medicine flow, it is ensured that medicine can slowly and evenly flow into the oral cavity of the patient, and the medicine feeding effect is improved. The situation that a large amount of medicine flows into or stimulates an operative incision is avoided, the auxiliary plate enables the medicine feeding pipe to be stably inserted into the oral cavity of a patient, and the comfort level and accuracy of medicine feeding are improved.

The invention relates to the technical field of cleft palate internal distraction devices, and discloses a nickel-titanium memory alloy cleft palate internal distraction device which comprises a palate steel support, a fixing block is mounted at the top of the palate steel support, and according to the nickel-titanium memory alloy cleft palate internal distraction device, a movable assembly is arranged, a control ring is rotated, and a rotating disc is driven to rotate in the fixing ring; a rectangular groove of a rotating disc drives a sliding rod to slide, so that clamping blocks move towards a threaded rod, a connecting rod slides along a strip-shaped groove of a connecting plate to stabilize a track until the two sets of clamping blocks are tightly attached to the threaded rod, rotation of the clamping blocks is preliminarily locked through friction force, and then a control rod is pushed to slide along a fixing strip to drive an elastic telescopic rod to stretch and be inserted into an annular rack of an inner gear ring; rotation of the control disc is further limited to indirectly lock the threaded rod, rotation of the threaded rod caused by palate movement or external collision of a patient is prevented, the cleft palate repairing effect is improved, meanwhile, palate tissue is prevented from being additionally damaged, safety of the device is enhanced, and discomfort of the patient is reduced.

The present application relates to a kind of mouse palatine midline stem cell separation and culture method, belong to stem cell separation culture technical field.The method of the present application includes the following steps: S1: separation 3-5 days old mouse maxillary tissue, retain palatine midline and its two sides tissue, tear two sides tissue along palatine midline, obtain unilateral palatine midline tissue;S2: with the medium containing serum, antibiotic and growth factor is cultured within 7 days in step S1 unilateral palatine midline tissue, obtain primary mouse palatine midline stem cell;The growth factor includes at least one of epidermal cell growth factor, fibroblast growth factor and transforming growth factor;S3: step S2 primary mouse palatine midline stem cell is subcultured, and obtain subculture mouse palatine midline stem cell.The method of the present application greatly shortens experimental time, and the palatine midline stem cell extracted is high, and it is convenient to operate, and it provides basis for the repair of cleft palate and other congenital developmental deformity.

A targeted imaging device can be inserted into a small oral cavity such as found in infants and the oral cavity of individuals unable to follow directions to obtain 2D or 3D images of the upper palate and gums or teeth. The intraoral imaging device positions an imaging element in an oral cavity of an infant, and probes successive fields of view for capturing a series of adjacent images in the oral cavity. A transparent, resilient tip is resistant to moisture and abrasion or discomfort which could result from a hard, sharp or rigid insertion. Captured images depict the palate and gumline, and aggregation or synthesis of consecutive fields of view allows reconstruction of a continuous image via photogrammetry. The reconstructed image is invoked for fabrication of a corrective appliance, and can be particularly beneficial for fabrication of a presurgical nasoalveolar molding often preceding surgical treatment for a cleft palate.

The invention relates to a method for separating and culturing mouse palate center seam stem cells, and belongs to the technical field of stem cell separation and culture. The method comprises the following steps: S1, separating maxillary tissues of a 3-5-day-old mouse, retaining a palate center seam and tissues on two sides of the palate center seam, and tearing the tissues on the two sides along the palate center seam to obtain unilateral palate center seam tissues; s2, using a culture medium containing serum, antibiotics and growth factors to culture the unilateral palate center seam tissue in the step S1 for 7 days or less to obtain primary mouse palate center seam stem cells; the growth factors comprise at least one of epidermal growth factors, fibroblast growth factors and transforming growth factors; and S3, carrying out subculture on the primary mouse middle palate seam stem cells in the step S2 to obtain subcultured mouse middle palate seam stem cells. According to the method, the experiment time is greatly shortened, the extracted palate central seam stem cells are high in stemness expression and convenient to operate, and a basis is provided for repairing congenital development malformation such as cleft palate.