Biodegradable tissue adhesion patch and preparation method thereof

A tissue and patch technology, applied in the field of biomedicine, which can solve the problems of desorption, limited rupture strength, and decreased adhesion strength.

Active Publication Date: 2021-09-07
诺一迈尔(苏州)生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN101378791B discloses a tissue sealing patch, which is made of fully synthetic polymer materials, there is no risk of inducing an immune response, but its resistance to rupture Limited, high brittleness, its adhesion strength will decrease after it is applied to the tissue surface, w

Method used

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  • Biodegradable tissue adhesion patch and preparation method thereof
  • Biodegradable tissue adhesion patch and preparation method thereof
  • Biodegradable tissue adhesion patch and preparation method thereof

Examples

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Embodiment 1

[0032] Embodiment 1. Layered tissue adhesive patch and its preparation

[0033] figure 1 It exemplarily shows a schematic diagram of the layered structure arrangement in the thickness direction of the tissue adhesive patch sample of this embodiment. like figure 1 As shown, the layered tissue adhesive patch of this embodiment includes an anti-adhesion layer 2, which has a thickness of 10 μm; and a tissue adhesive layer 1, wherein the tissue adhesive layer has a surface for contacting tissue, and includes Poly(N-vinylpyrrolidone), polyacrylic acid and polyacrylic acid polyethylene glycol succinimidyl carboxymethyl ester as multipolymer matrix and polyethylene glycol diacrylate as toughening agent; the anti-blocking layer 2 Having a surface opposite the tissue-contacting surface and comprising poly(lactic-co-glycolic acid).

[0034] The above-mentioned tissue adhesive patch is prepared through the following steps:

[0035] (1) Preparation of anti-adhesive layer: 10g of poly...

Embodiment 2

[0040]Adopt the method identical with embodiment 1, difference is: the charging amount of toughening agent polyethylene glycol and acrylate (PEGDA) are different. Specifically, when preparing the tissue adhesion layer, the dosage of the toughening agent polyethylene glycol diacrylate (PEGDA, Mw=1000Da) was changed to 0.5% of the total weight of the monomer, and a tissue with a thickness of 50 μm was prepared. Adhesive patch sample #2. The ratio of each monomer in the tissue adhesion layer in this embodiment is listed in Table 1 below.

Embodiment 3

[0042] Adopt the method identical with embodiment 1, difference is: the charging amount of toughening agent polyethylene glycol and acrylate (PEGDA) is different. Specifically, when preparing the tissue adhesion layer, the dosage of the toughening agent polyethylene glycol diacrylate (PEGDA, Mw=1000Da) was changed to 2% of the total weight of the monomer, and a tissue with a thickness of 50 μm was prepared. Adhesive patch sample #Y. The ratio of each monomer in the tissue adhesion layer in this embodiment is listed in Table 1 below.

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Abstract

Disclosed is a biodegradable tissue adhesion patch and a preparation method thereof. The tissue adhesion patch comprises a tissue adhesion layer comprising a multi-polymer matrix providing tissue adhesion and a toughening polymer dispersed in the multi-polymer matrix, and an anti-adhesion layer comprising a polymer with the film-forming properties. The tissue adhesion patch in the invention has strong adhesive force and excellent cracking resistance.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a biodegradable layered tissue adhesive patch and a preparation method thereof. Background technique [0002] Clinically, surgical suturing is used to combine tissues after injury or surgery. Due to the disadvantages of long suturing time and secondary tissue damage during suturing, some complications are usually caused, such as air leakage from the lung wound in thoracic surgery, Cerebrospinal fluid leakage after dural suturing in neurosurgery, etc. In recent years, tissue-adhesive patches have attracted widespread attention due to their advantages of simple operation, time-saving and the ability to avoid related complications such as air leakage and fluid leakage after suturing, which can be used as an alternative to surgical suturing. This tissue adhesive patch should have good biocompatibility, be bioabsorbable, and can be cleaved by hydrolysis or enzymolysis so that it can be met...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00B32B27/36B32B27/06B32B33/00C08F283/06C08F220/06C08F226/10C08F2/48
CPCA61L24/0094C08F283/065C08F2/48A61L24/046A61L24/001B32B27/36B32B27/06B32B33/00C08F220/06C08F226/10
Inventor 潘信
Owner 诺一迈尔(苏州)生命科技有限公司
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