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Photosensitive antibacterial modified porphyrin metal organic framework material and preparation method thereof

A metal-organic framework, photosensitive antibacterial technology, used in antibacterial drugs, wave energy or particle radiation treatment materials, medical preparations with non-active ingredients, etc. and other problems, to achieve the effect of improving sterilization ability, avoiding self-quenching, and good application prospects

Active Publication Date: 2021-09-24
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because porphyrin molecules are insoluble in physiological environment and prone to self-aggregation and self-quenching, it is difficult to achieve better photosensitive activity, and when traditional porphyrin materials are used in photosensitive antibacterial, it is difficult to reach the bacterial infection site in vivo. lead to less effective treatment

Method used

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  • Photosensitive antibacterial modified porphyrin metal organic framework material and preparation method thereof
  • Photosensitive antibacterial modified porphyrin metal organic framework material and preparation method thereof
  • Photosensitive antibacterial modified porphyrin metal organic framework material and preparation method thereof

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Embodiment 1

[0050] A method for preparing a photosensitive and antibacterial modified porphyrin metal-organic framework material, comprising the following steps:

[0051] (1) Preparation of porphyrin metal-organic framework (PCN-224) materials with surface-modified carboxyl ligands:

[0052] Weigh 40mg of meta-tetrakis(4-carboxyphenyl)porphyrin, 120mg of zirconium oxychloride octahydrate, 1.12g of benzoic acid in a round bottom flask, then add 40mL of N,N-dimethylformamide to dissolve it by ultrasonication, uniform Mixed and heated to 90 ° C, magnetic stirring reaction 5h. After the reaction is completed, cool to room temperature, collect the precipitate (product) by centrifugation (12000rpm, 20min), wash with N,N-dimethylformamide centrifugation (12000rpm, 20min) three times, acetone centrifugation (12000rpm, 20min) three times, Finally, dry in a vacuum oven at 60°C overnight to obtain a porphyrin metal-organic framework PCN-224 with carboxylic acid ligands on the surface;

[0053] (2)...

Embodiment 2

[0065] A method for preparing a photosensitive and antibacterial modified porphyrin metal-organic framework material, comprising the following steps:

[0066] (1) with embodiment 1;

[0067] (2) Activation of the surface carboxyl groups of the porphyrin metal-organic framework:

[0068] Weigh 60 mg of porphyrin metal-organic framework material rich in carboxyl ligands on the surface, disperse it uniformly in 30 mL of N,N-dimethylformamide, add 40 mg of dicyclohexylcarbodiimide, and stir the reaction at room temperature in a dark environment 0.5h, centrifuge to remove the supernatant (12000rpm, 15min), and wash once with N,N-dimethylformamide to obtain the surface carboxyl-activated porphyrin metal-organic framework material;

[0069] (3) Functionalization of surface-targeting ligands for porphyrin metal-organic frameworks:

[0070] Redisperse the activated porphyrin metal-organic framework in 25 mL of new N,N-dimethylformamide, weigh 20 mg of vancomycin and dissolve it in 5 ...

Embodiment 3

[0073] A method for preparing a photosensitive and antibacterial modified porphyrin metal-organic framework material, comprising the following steps:

[0074] (1) with embodiment 1;

[0075] (2) with embodiment 2;

[0076](3) Functionalization of surface-targeting ligands for porphyrin metal-organic frameworks:

[0077] Redisperse the activated porphyrin metal-organic framework in 25 mL of new N,N-dimethylformamide, weigh 20 mg of antimicrobial peptide (sequence KWKKLLKKLLKLLKK) and dissolve it in 5 mL of N,N-dimethylformamide 5 mg of 4-dimethylaminopyridine was added, and the mixed solution was placed in a dark environment to react at room temperature for 5 hours, centrifuged to remove the supernatant, and washed three times with N,N-dimethylformamide to obtain the surface-modified antimicrobial peptide porphyrin Phenyl metal-organic framework (antimicrobial peptide modified PCN-224).

[0078] The antimicrobial peptide modified PCN-224 prepared in embodiment 3 is to the ba...

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Abstract

The invention relates to a photosensitive antibacterial modified porphyrin metal organic framework material and a preparation method thereof, and belongs to the technical field of antibacterial materials. The preparation method comprises the following steps: firstly, carrying out carboxyl activation on a porphyrin metal organic framework material with photosensitive activity by utilizing a carbodiimide method; and then, carrying out amide condensation on a targeting ligand with amino with the activated porphyrin metal organic framework material, so that the functionalized nano-antibacterial material with the morphology and the crystal structure not affected is obtained, and the material has the enhanced bactericidal performance on bacteria. The photosensitive antibacterial material with targeting ligand modification can target specific infectious bacteria, has better bactericidal performance, and has a very good application prospect.

Description

technical field [0001] The invention relates to a photosensitive and antibacterial modified porphyrin metal organic framework material and a preparation method thereof, belonging to the technical field of antibacterial materials. Background technique [0002] Bacterial infection is a serious threat to human health and has aroused widespread concern. Antibiotics were once proven to be very effective in the treatment of bacterial infections, but the overuse of antibiotics has led to the emergence and increase of drug-resistant bacteria. Therefore, it is of great significance to develop other effective methods for treating bacterial infections. Antibacterial photodynamic therapy refers to the use of photosensitizers in the presence of oxygen to absorb light of a certain wavelength to generate active oxygen, especially singlet oxygen ( 1 o 2 ), and kill microorganisms through bursts of oxidative stress. Photosensitizers with higher photosensitizing activity are the key to ph...

Claims

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Application Information

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IPC IPC(8): A61K47/55A61K47/64A61K41/00A61K38/14A61K38/10A61K38/16A61P31/04
CPCA61K47/55A61K47/552A61K47/64A61K41/0076A61K38/14A61K38/10A61K38/16A61P31/04A61K2300/00Y02A50/30
Inventor 陈丽建严秀平王江悦刘瑶瑶龚嘉华
Owner JIANGNAN UNIV