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Bionic hydrogel tissue adhesive and preparation method thereof

A tissue adhesive and hydrogel technology, applied in surgical adhesives, pharmaceutical formulations, applications, etc., can solve the problems of low bonding strength and poor mechanical properties, and achieve the effect of simplifying the preparation process

Pending Publication Date: 2021-09-24
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Degradable natural polymer hydrogel has good biocompatibility and is safe and non-toxic. Some biopolymers also have antibacterial and hemostatic properties. Insufficient bonding strength is not high

Method used

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  • Bionic hydrogel tissue adhesive and preparation method thereof
  • Bionic hydrogel tissue adhesive and preparation method thereof
  • Bionic hydrogel tissue adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] as attached Figure 1-2 Shown, a kind of bionic hydrogel tissue adhesive, its preparation method, comprises the steps:

[0048] S1, preparation of aldehyde polysaccharide

[0049] Prepare phosphate buffer solution with pH 5.0 and 7.4;

[0050] Dissolve 2.0 g of hyaluronic acid with a molecular weight of 2 million and 1 g of sodium periodate in 200 mL of a phosphate buffered saline solution with a pH of 5.0, and stir for 10 hours at room temperature in the dark;

[0051] After the reaction, 2 mL of ethylene glycol was added to the reaction solution to neutralize excess sodium periodate and stirred for 1 h to obtain a reaction mixture;

[0052]The reaction mixture was put into a dialysis bag, dialyzed against ultrapure water for 48 hours and freeze-dried; to obtain aldehyde hyaluronic acid;

[0053] S2, aldehyde hyaluronic acid grafted dopamine

[0054] Dissolve 1.0g of aldehyde-based hyaluronic acid in 100mL of phosphate buffer solution with pH=5.0, and add 0.5g of d...

Embodiment 2

[0074] This example is carried out on the basis of the above examples, and the similarities with the above examples will not be repeated. The amino polysaccharide described in this example is hydroxyethyl chitosan.

[0075] A preparation method of a bionic hydrogel tissue adhesive, comprising the steps of:

[0076] S1, preparation of aldehyde polysaccharide

[0077] Prepare phosphate buffer solution with pH 5.0 and 7.4;

[0078] Dissolve 2.0 g of hyaluronic acid with a molecular weight of 2 million and 1 g of sodium periodate in 200 mL of a phosphate buffered saline solution with a pH of 5.0, and stir for 10 hours at room temperature in the dark;

[0079] After the reaction, 2 mL of ethylene glycol was added to the reaction solution to neutralize excess sodium periodate and stirred for 1 h to obtain a reaction mixture;

[0080] The reaction mixture was put into a dialysis bag, dialyzed against ultrapure water for 48 hours and freeze-dried; to obtain aldehyde hyaluronic acid;...

Embodiment 3

[0091] This embodiment is carried out on the basis of the above-mentioned embodiment 1 or 2, and the similarities with the above-mentioned embodiment will not be repeated. In this embodiment, the polysaccharide is sodium alginate, and the amino polysaccharide is carboxymethyl shell glycans.

[0092] A preparation method of a bionic hydrogel tissue adhesive, comprising the steps of:

[0093] S1, preparation of aldehyde polysaccharide

[0094] Prepare phosphate buffer solution with pH 5.0 and 7.4;

[0095] Dissolve 2.0 g of sodium alginate with a molecular weight of 2 million and 1 g of sodium periodate in 200 mL of a phosphate buffer solution with a pH of 5.0, and stir at room temperature for 10 hours in the dark;

[0096] After the reaction, 2 mL of ethylene glycol was added to the reaction solution to neutralize excess sodium periodate and stirred for 1 h to obtain a reaction mixture;

[0097] The reaction mixture was put into a dialysis bag, dialyzed against ultrapure wat...

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Abstract

The invention discloses a bionic hydrogel tissue adhesive and a preparation method thereof. The preparation method comprises the following steps of: mixing and dissolving polysaccharide and sodium periodate in a phosphate buffer solution for reaction; adding ethylene glycol, stirring, filling a dialysis bag with the mixture, dialyzing ultrapure water, and freeze-drying to obtain aldehyde polysaccharide; dissolving the aldehyde polysaccharide in the phosphate buffer solution, adding dopamine hydrochloride for reaction, filling the dialysis bag with the mixture, dialyzing ultrapure water, and freeze-drying to obtain dopamine grafted aldehyde polysaccharide; dissolving the dopamine grafted aldehyde polysaccharide and amino polysaccharide in the phosphate buffer solution to obtain solutions; and mixing the solutions into gel by adopting a reaction device to obtain the hydrogel adhesive. According to the preparation method, grafted small molecules for promoting wet adhesion are grafted to polysaccharide molecules and then react with amino polysaccharide to prepare the bionic hydrogel tissue adhesive which is injectable, self-healing and excellent in adhesion performance, and the problems of poor mechanical performance and low bonding strength under the condition of body fluid in the prior art are solved.

Description

technical field [0001] The invention relates to the technical field of biological tissue adhesives, in particular to a bionic hydrogel tissue adhesive and a preparation method thereof. Background technique [0002] In the field of tissue repair, traditional wound treatment methods include sutures, bone needles, fixers, etc. These methods are not only invasive, painful to treat, poor in biocompatibility, but also prone to secondary injuries. Sutures are also prone to foreign body reactions, and there is a high risk of infection at the ligation site, which can easily cause chronic wounds and even threaten the lives of patients. Therefore, tissue adhesives that are easy to operate, less traumatic, less likely to be infected or cause secondary injuries are expected to gradually replace sutures and bone needles, and become new materials for wound treatment. [0003] Five major requirements listed for the development of tissue adhesives are safety, usability, efficacy, cost, and ...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/043A61L24/0031A61L24/001A61L2400/06C08L5/08
Inventor 何湘张冰雁吴鑫王杰奚桢浩赵玲
Owner EAST CHINA UNIV OF SCI & TECH
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