Fluorine-containing polysaccharide high-molecular compound and preparation method thereof

A polymer compound and polysaccharide technology, which is applied in the field of fluorine-containing polysaccharide polymer compounds and its preparation, can solve the problems of poor material stability, difficult reagent deoxygenation and fluorination, and low physical strength, so as to improve stability and strength, improve Physical and chemical properties, effects of good biocompatibility

Pending Publication Date: 2021-10-22
DEKE MEDTECH HANGZHOU INC
0 Cites 0 Cited by

AI-Extracted Technical Summary

Problems solved by technology

[0002] Natural polysaccharide polymer materials have advantages in biocompatibility, controlled degradation, non-toxicity, and application safety, but their material stability is poor and their physical strength is not high
In compound synthesis, especially drug synthesis, the introduction of fluorine atoms into target molecules can often change its physical and c...
View more

Abstract

The invention discloses a preparation method of a fluorine-containing polysaccharide high-molecular compound, which comprises the following step of: reacting a polysaccharide high-molecular compound with fluorosulfonyl picolinic acid for at least 30 minutes in a solvent in an alkaline environment at 0-80 DEG C to obtain the fluorine-containing polysaccharide high-molecular compound. The polysaccharide high-molecular compound is water-soluble, and each structural unit contains at least two hydroxyl groups. According to the fluorine-containing polysaccharide high-molecular compound and the preparation method thereof, fluorine atoms are introduced into the polysaccharide high-molecular compound, so that the physical and chemical properties are improved.

Technology Topic

Structural unitAqueous solubility +7

Image

  • Fluorine-containing polysaccharide high-molecular compound and preparation method thereof
  • Fluorine-containing polysaccharide high-molecular compound and preparation method thereof
  • Fluorine-containing polysaccharide high-molecular compound and preparation method thereof

Examples

  • Experimental program(11)

Example Embodiment

[0046] Example 1
[0047] At 70 ° C oil bath, 0.161 g of chitosan, 4 ml acetonitrile, 6 ml of 20% KOH aqueous solution, 0.225 grams of 2-fluoronacyridine-4-formic acid placed under nitrogen protection The mixture was stirred in the tube for 3 hours, and the reaction formulation is as follows:
[0048]
[0049] After completion of the reaction, cooled to room temperature, 1 mole per liter of hydrochloride system was added to the aqueous phase pH test strip. Ethyl acetate and water were added, and the resulting organic phase was added to give a saturated brine, then anhydrous magnesium sulfate was dried, carnamed dry solvent, and 0.071 g of the product was divided into a silica gel chromatography column and 44% yield.
[0050] Infrared and flu fluoroscopy were performed on the preparation product, the result was IR (Thinfilm): 3263.57, 1550.10, 1400.78, 1300.55, 1026.29CM -1 , 19 F NMR (470MHz, H 2 O, 90 ° C, δ): - 177.7 (DT, J = 55.3, 34.3 Hz), the structural formula of the preparation product is as follows:
[0051]

Example Embodiment

[0052] Example 2
[0053] At 70 ° C oil bath, 0.161 g of glycan, 4 ml acetonitrile, 6 ml of 20% KOH aqueous solution, 0.225 grams of 5-fluoronacyridine-3-formic acid under nitrogen protection The mixture was stirred in the tube for 3 hours, and the reaction formulation is as follows:
[0054]
[0055] After completion of the reaction, cooled to room temperature, 1 mole per liter of hydrochloride system was added to the aqueous phase pH test strip. Ethyl acetate and water were added, and the obtained organic phase was added to give a saturated brine, then anhydrous magnesium sulfate was dried, carnamed dry solvent, divided by silica gel chromatography column, 0.049 g, 30% yield.
[0056] Infrared and flu fluoroscopy were performed on the preparation product, the result was IR (Thinfilm): 3263.57, 1550.10, 1400.78, 1300.55, 1026.29CM -1 , 19 F NMR (470MHz, H 2 O, 90 ° C, δ): - 177.7 (DT, J = 55.3, 34.3 Hz), the structural formula of the preparation product is as follows:
[0057]

Example Embodiment

[0058] Example 3
[0059] At 70 ° C oil bath temperature, 0.161 g of chitosan, 4 ml acetonitrile, 6 ml of 20% KOH aqueous solution, 0.225 grams of 2-fluoronacyridine-6-formic acid were placed under nitrogen protection The mixture was stirred in the tube for 3 hours, and the reaction formulation is as follows:
[0060]
[0061] After completion of the reaction, cooled to room temperature, 1 mole per liter of hydrochloride system was added to the aqueous phase pH test strip. Ethyl acetate and water were added, and the obtained organic phase was added to give a saturated brine, then anhydrous magnesium sulfate was dried, carnamed dry solvent, divided by silica gel chromatography column, 0.022 grams, 13% yield.
[0062] Infrared and flu fluoroscopy were performed on the preparation product, the result was IR (Thinfilm): 3263.57, 1550.10, 1400.78, 1300.55, 1026.29CM -1 , 19 F NMR (470MHz, H 2 O, 90 ° C, δ): - 177.7 (DT, J = 55.3, 34.3 Hz), the structural formula of the preparation product is as follows:
[0063]

PUM

no PUM

Description & Claims & Application Information

We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.

Similar technology patents

Preparation method of graphene integrated heating decorative plate

PendingCN114258166AIncrease space saturationImprove physical and chemical properties
Owner:甘肃暖季新能源科技有限公司

Classification and recommendation of technical efficacy words

  • Improves strength and stability
  • Improve physical and chemical properties

Multi-head branch-control 3D printer

ActiveCN107175816AImprove printing efficiencyImproves strength and stability
Owner:LUOYANG INST OF SCI & TECH

Full-aluminum alloy material van carriage and manufacturing process

InactiveCN110588806AImproves strength and stabilityReduce the weight of the carriage
Owner:方大新材料(江西)有限公司

Method for eliminating efflorescence of magnesium oxychloride wall through magnesium sulfate

InactiveCN105884320AImproves strength and stabilityovercome porosity
Owner:广东晶盈环保建材实业有限公司

Selective water plugging method for high-water-content oil well of bottom water reservoir

ActiveCN113464087AStrengthen the pressure cone effectImproves strength and stability
Owner:SOUTHWEST PETROLEUM UNIV

Cardiac volume reduction system

InactiveCN106073947AImproves strength and stabilitygood push ability
Owner:苏州莱诺医疗器械有限公司

Deoxidation catalyst for olefin gas, preparation method and application thereof

ActiveCN103157471AImprove physical and chemical propertiesImprove physical and mechanical properties
Owner:SOUTHWEST RES & DESIGN INST OF CHEM IND

Impregnating compound

Owner:TONGCHENG GLASS FIBER OF ANHUI DANFENG GROUP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products