Fluorine-containing polysaccharide high-molecular compound and preparation method thereof

Abstract

The invention discloses a preparation method of a fluorine-containing polysaccharide high-molecular compound, which comprises the following step of: reacting a polysaccharide high-molecular compound with fluorosulfonyl picolinic acid for at least 30 minutes in a solvent in an alkaline environment at 0-80 DEG C to obtain the fluorine-containing polysaccharide high-molecular compound. The polysaccharide high-molecular compound is water-soluble, and each structural unit contains at least two hydroxyl groups. According to the fluorine-containing polysaccharide high-molecular compound and the preparation method thereof, fluorine atoms are introduced into the polysaccharide high-molecular compound, so that the physical and chemical properties are improved.

Description

Technical field [0001] The present application relates to the field of organic synthesis, and in particular, to a fluorine polysaccharide polymer compound and a preparation method thereof. Background technique [0002] Natural polysaccharide polymer materials have advantages in biocompatibility, control degradation, non-toxic, and application safety, but the stability of materials is poor, and the physical intensity is not high. In the compound synthesis, especially drug synthesis, fluorine atoms can generally change their physical and chemical properties in the target molecules, although there are many deprothal fluid reagents to be reported in the past 20 years, but their applicable environment It is generally an organic solvent, and the natural polysaccharide polymer material is soluble in the nature of the water disadvantaged in an organic solvent, which is difficult to be a general reagent deoxidin. Inventive content [0003] Based on this, a method of preparing a fluorine ...

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Problems solved by technology

[0002] Natural polysaccharide polymer materials have advantages in biocompatibility, controlled degradation, non-toxicity, and application safety, but their material stability is poor and their physical strength is not high

In compound synthesis, especially drug synthesis, the introduction of fluorine atoms into target molecules can often change its physical and chemical properties greatly. Although many deoxyfluorinated reagents have been reported in the past 20 years, their applicable environment Generally, they are organic solvents. Natural polysaccharide polymer materials are easily soluble in water and difficult to dissolve in organic solvents, making it difficult for them to be deoxyfluorinated by general reagents.

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