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Gold-silver nanoflower and preparation method and application thereof

A nanoflower, gold and silver technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of large particle size of gold nanoneedle clusters, destroying the physiological stability of materials, and unfavorable material promotion and application, and achieve biofilms. The effect of excellent penetration, good biosafety, and good biocompatibility

Active Publication Date: 2021-11-02
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the step of modifying biocompatible ligands may require the introduction of various organic reagents and centrifugal washing, which will destroy the physiological stability of the material
Patent application CN110605383A discloses a gold nano-needle cluster material and its preparation method. The steps of the synthesis method are cumbersome, the preparation process requires heating conditions, and the prepared gold nano-needle cluster material has a large particle size, which is not conducive to the popularization and application of the material.

Method used

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  • Gold-silver nanoflower and preparation method and application thereof
  • Gold-silver nanoflower and preparation method and application thereof
  • Gold-silver nanoflower and preparation method and application thereof

Examples

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Embodiment 1

[0039] Take 50μL of 0.1wt% polylysine solution in a glass reaction bottle filled with 10mL of ultrapure water, stir at room temperature for 2min, then add 75μL of 1wt% chloroauric acid solution, continue stirring for 2min, then add 30μL of 6mmol / L Silver nitrate solution, 40μL of 0.1mol / L ascorbic acid solution was added within 45s, and the solution was observed to rapidly change from colorless to blue. After continuing to react for 10 minutes, stop stirring, and the product prepared in this example was obtained.

[0040] The product prepared in this embodiment was scanned by transmission electron microscope, figure 1 Gold and silver nanoflowers transmission electron microscope scanning picture prepared for embodiment 1, figure 2 A transmission electron microscope scanning image of a single gold and silver nanoflower prepared in Example 1. Depend on figure 1 and figure 2 It can be seen that the product prepared in this example is the target gold and silver nanoflowers, the ...

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Abstract

The invention discloses a gold-silver nanoflower and a preparation method and application thereof. The gold-silver nanoflower is a gold-silver nanomaterial coated with polylysine, and the preparation method of the gold-silver nanoflower comprises the steps of: mixing polylysine with a gold source, and then sequentially mixing with a silver source and a reducing agent for reaction to obtain the gold-silver nanoflower. According to the invention, the gold-silver nanoflower material with good biocompatibility and high physical and chemical stability can be obtained through a one-pot green synthesis method. The synthesis method has the advantages of simple steps, greenness, safety, high efficiency, rapidness and capability of implementing mass production.

Description

technical field [0001] The invention belongs to the technical field of composite nanoparticle preparation, and in particular relates to a gold and silver nanoflower and its preparation method and application. Background technique [0002] Nanomaterials have unique optical, thermal, and electrical properties, and have been widely used in various fields, such as sensors, optoelectronic materials, photothermal therapy, and biological imaging. Studies have shown that the performance of nanomaterials largely depends on the shape, structure, size and composition of materials, so it is of great significance to study nanomaterials with special morphology. Among them, noble metal nanomaterials are favored by scientists because of their tunable local surface plasmon resonance effect. The special morphology of anisotropic gold nanomaterials often has the field effect of the tip or the void in the particle, which makes the plasmon resonance absorption peak redshift to the near infrared...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/02B22F1/00A61K41/00A61K47/34A61P31/04A61P31/10A61P35/00G01N21/33G01N21/3577G01N21/359B82Y5/00B82Y15/00B82Y20/00B82Y30/00B82Y40/00
CPCB22F9/24A61K41/0052A61K47/34A61P35/00A61P31/04A61P31/10G01N21/3577G01N21/359G01N21/33B82Y5/00B82Y15/00B82Y20/00B82Y30/00B82Y40/00Y02A50/30
Inventor 吕倩邹丽丽刘海信
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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