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High-adenosine and high-ergosterol fermented cordyceps sinensis powder and production method thereof

A technology of high-adenosine high-ergosterol, fermented Cordyceps fungus powder, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the overall level of adenosine and ergosterol content Large fluctuations, high production costs, few deviation adjustment methods, etc., to achieve the effect of improving production efficiency and equipment utilization, quality stability, and quality improvement

Active Publication Date: 2021-11-09
JIANGXI GUOYAO PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process has been used in production until now, but it is difficult to adapt to the requirements of the new version of GMP, the process control accuracy is low, and there are few deviation adjustment methods, resulting in large fluctuations in the overall level of adenosine and ergosterol in the finished product, and the production process is time-consuming and labor-intensive. higher cost

Method used

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  • High-adenosine and high-ergosterol fermented cordyceps sinensis powder and production method thereof
  • High-adenosine and high-ergosterol fermented cordyceps sinensis powder and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] S1. Start the feeding pump, put 30 tons of bacteria with an age of 55h, a bacterial concentration of 24ml / 100ml, a solid content of 4.59%, a PH of 4.13, a well-differentiated primordium, a whitish material color, and no bacterial contamination. The standard cordyceps fermentation liquid is pumped into the raw material storage tank for storage, and the sterile air is introduced to control the tank pressure of 0.02MPa, cooled with a water jacket at 9°C, and the material temperature is kept at 30°C, and the storage time is 15h. Start the feeding pump, pump the Cordyceps fermented liquid into the ceramic membrane filter with a membrane aperture of 100nm, control the inlet pressure to be 0.4±0.05MPa, the medium pressure to 0.3±0.05MPa, the outlet pressure to be 0.15±0.05MPa, and the temperature to be 50℃ , pH after membrane: 4.89, mycelium and filtrate were separated, 31.2% of mother liquor was removed, and a concentrated solution of Cordyceps ceramic membrane with a solid co...

Embodiment 2

[0052] S1. Start the feeding pump, put 30 tons of bacteria with an age of 65h, a bacterial concentration of 28ml / 100ml, a solid content of 3.97%, a pH of 5.29, a well-differentiated primordium, a whitish material color, and no bacterial contamination. The cordyceps fermented liquid that reaches the standard of storage is pumped into the raw material storage tank for storage, and the sterile air is introduced into the control tank to control the pressure of 0.04Mpa, and the water jacket is cooled at 9°C. Start the feed pump to pump the Cordyceps fermentation broth into the TiO with a membrane pore size of 200nm 2 In the metal oxide membrane filter, the inlet pressure is controlled to be 0.4±0.05Mpa, the medium pressure is 0.3±0.05Mpa, the outlet pressure is 0.15±0.05Mpa, the temperature is 40°C, the pH after the membrane is 5.62, and the mycelium is separated from the filtrate. Remove 52.4% of the mother liquor to obtain Cordyceps TiO with a solid content of 8.13% 2 Metal oxid...

Embodiment 3

[0057] S1. Start the feeding pump, put 30 tons of bacteria with age 75h, bacteria concentration of 32ml / 100ml, solid content: 3.10%, PH: 5.65, good primordial differentiation, white color, and no bacterial contamination. The cordyceps fermented liquid that has reached the standard of storage is pumped into the raw material storage tank for storage, and the sterile air is introduced into the control tank to control the pressure of 0.05Mpa. Start the feeding pump, pump the Cordyceps fermented liquid into the polyfluoropolymer organic membrane filter with a membrane aperture of 600nm, control the inlet pressure: 0.4±0.05Mpa, the middle pressure: 0.3±0.05Mpa, and the outlet pressure: 0.15±0.05Mpa , the temperature is 30℃, the pH after the membrane is 5.93, and the mycelium is separated from the filtrate. 68.5% of the mother liquor was removed to obtain a concentrated solution of Cordyceps polyfluoropolymer organic membrane with a solid content of 9.36%.

[0058] S2. Start the fee...

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Abstract

The invention discloses high-adenosine and high-ergosterol fermented cordyceps sinensis fungus powder and a production method thereof, and relates to the technical field of fermented cordyceps sinensis fungus powder. The production method comprises the following steps: pumping fermentation broth that meets requirements into a raw material storage tank, and controlling tank pressure, material temperature and storage time; then filtering, pH change before and after filtering is less than or equal to 1.0, separating mycelium from the filtrate and removing fermentation broth; pumping into a concentration buffer storage tank, controlling storage vacuum degree, temperature and storage time, then concentrating, pH change before and after concentration is less than or equal to 1, and discharging; and putting the discharged material into a storage tank with a dry buffer after passing through an ultrahigh-temperature sterilizer at 135-180 DEG C for 4-7 seconds, controlling vacuum degree and storage time, and finally drying, crushing and the like to obtain a finished product. The method has beneficial effects that product quality is improved by controlling tank discharge standard, filtering, concentrating, drying and other process conditions, water content of the finished product is 1.0-7.0%, adenosine content is greater than or equal to 0.32%, and ergosterol content is greater than or equal to 0.4%.

Description

technical field [0001] The invention belongs to the technical field of production of fermented cordyceps fungus powder, in particular to a fermented cordyceps fungus powder with high adenosine and high ergosterol and a production method thereof. Background technique [0002] Cordyceps sinensis is a valuable and strong nourishing Chinese medicinal material in my country. Studies have shown that Cordyceps sinensis contains a variety of pharmacologically active substances and has a variety of pharmacological effects. Anti-diabetes, lowering blood lipids, invigorating the lungs and nourishing the kidneys, hemostasis and resolving phlegm, and secreting essence and nourishing qi have significant effects, and the clinical dosage is increasing day by day. However, due to the special habitat of Cordyceps sinensis, the natural resources are extremely limited, coupled with the excessive excavation by humans, the resources of wild Cordyceps sinensis are decreasing year by year. In order...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P37/02A61P35/00A61P39/06A61P39/00A61P1/16A61P3/10A61P3/06A61P1/14A61P11/10
CPCA61K36/068A61P37/02A61P35/00A61P39/06A61P39/00A61P1/16A61P3/10A61P3/06A61P1/14A61P11/10A61K2236/19A61K2236/51
Inventor 邓愍民杨明钟承赞李进进肖永梅
Owner JIANGXI GUOYAO PHARMA LLC
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