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5-aminolevulinic acid ester, and application and pesticide composition thereof
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A technology of aminolevulinic acid ester and pesticide composition, applied in the field of use and pesticide composition, 5-aminolevulinic acid ester compound, capable of solving 5-ALA stability and poor fat solubility, spasm and death, 5-ALA ALA price and other issues
Pending Publication Date: 2021-11-09
HUNAN FURUI BIOPHARMA TECH CO LTD
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[0002] 5-Aminolevulinic acid (5-ALA) is a biological endogenous substance and a precursor substance for the biosynthesis of animal hemoglobin and plantchlorophyll. It is widely used in the field of medicine and can be used as a photosensitizer for the treatment of various cancers. Its application The earliest report in the field of pesticides was found in the "Chicago News" in the United States. A certain concentration of 5-ALA under light can effectively kill field weeds. In addition, it can cause convulsions and death to flies, cockroaches and other pests. Afterwards, there were also many reports on the content of killing pests and diseases by its photooxidation, but there has been no listing of pesticides containing 5-ALA
[0003] After research, it was found that the fundamental reason is that 5-ALA has poor stability and fat solubility, and requires a large concentration to produce the effect of killing diseases and insect pests. However, 5-ALA is expensive and difficult to use on a large scale, and it does not have the ability to prepare pesticides. the value of
Method used
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[0029] Add 1000ml of methanol into the reaction vessel, add 10g of 2-methylglycerol and 16g of 5-aminolevulinic acid under stirring, heat up to 60°C and stir evenly, then slowly add 20ml of concentrated sulfuric acid dropwise, keep warm for 2 hours, and concentrate to a small volume, add 600ml of dichloromethane to dissolve, add 500ml of water and stir rapidly for 20 minutes, separate the dichloromethane layer, add 300g of anhydrousmagnesiumsulfate, stir for 30 minutes, and let stand overnight. Filtrate, take the filtrate, add 30ml of concentrated hydrochloric acid dropwise under stirring, stir for 2 hours, adjust the pH value to neutral with sodiumhydroxide, concentrate to a small volume, crystallize and dry to obtain 2-methylpropane-1,2,3-tri (5-aminolevulinate) 13g.
Embodiment 2
[0030] Embodiment 2, the preparation of pesticide composition suspending agent
[0031] Weigh each component by the following weight: 1Kg of 2-methylpropane-1,2,3-tris(5-aminolevulinate) hydrochloride, 32Kg of fluthiazol, 1Kg of sodium alkylsulfonate, Naphthalenesulfonic acid polycondensate sodium salt 4Kg, xanthan gum 0.2Kg, ethylene glycol 4Kg, water 56.8Kg; using water as the medium, add the rest of the components into a sand mill, and grind them into 2-formazan Propane-1,2,3-tris(5-aminolevulinate) hydrochloride and fluthiazol compounded suspending agent.
Embodiment 3
[0032] Embodiment 3, the preparation of pesticide composition water dispersant
[0033] Weigh each component according to the following weight: 2-methylpropane-1,2,3-tris(5-aminolevulinate) hydrochloride 5Kg, fluthiazol sulfone 15Kg, sodium naphthalenesulfonateformaldehyde condensate 10Kg , sodium n-butylnaphthalene sulfonate 3Kg, kaolin 77Kg; The former medicine and powdery carrier, wetting dispersant are mixed and pulverized, add water after kneading, add granulator and carry out granulation, then through drying, sieving (according to sieve range) to obtain the water-dispersible granules compounded by 2-methylpropane-1,2,3-tris(5-aminolevulinate) hydrochloride and fluthiazol.
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Abstract
The invention provides a 5-aminolevulinic acid ester, and application and a pesticide composition thereof. The 5-aminolevulinic acid ester is formed by condensation of three 5-ALA and corresponding glycerol derivatives through concentrated sulfuric acid, and R1 is one or more of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tertiary butyl, n-amyl, isoamyl and neopentyl. The invention provides a compound structure which is developed by taking 5-ALA as a basic structure and has pesticidedruggability, provides a specific preparation method of the structure, also provides an implementation scheme of application of the compound in pesticides, and overcomes the defects that 5-ALA is relatively poor in stability and fat solubility and needs relatively high concentration to kill diseases and insect pests, and the preparation method is suitable for industrial production.
Description
technical field [0001] The present invention relates to the technical field of pesticide preparation, and more specifically relates to a 5-aminolevulinic acid ester compound, its use and a pesticide composition. Background technique [0002] 5-Aminolevulinic acid (5-ALA) is a biological endogenous substance and a precursor substance for the biosynthesis of animal hemoglobin and plantchlorophyll. It is widely used in the field of medicine and can be used as a photosensitizer for the treatment of various cancers. Its application The earliest report in the field of pesticides was found in the "Chicago News" in the United States. A certain concentration of 5-ALA under light can effectively kill field weeds. In addition, it can cause convulsions and death to flies, cockroaches and other pests. Afterwards, there are also many documents reporting on the content of killing pests and diseases by its photooxidation, but there has been no listing of pesticides containing 5-ALA. [00...
Claims
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Application Information
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