A kind of 3D printing antibacterial hydrogel dressing and preparation method thereof
A 3D printing and hydrogel technology, which can be used in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of inability to achieve wound gas exchange, unfavorable wound healing, etc., to improve UV stability, promote wound healing, and strong antibacterial performance effect
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Embodiment 1
[0084] A method for preparing halamine modified ceria nanoparticles, comprising the steps of:
[0085] (1) Dissolve 0.1 mol of cerium nitrate and 0.3 mol of urea in 100 mL of DMF solution respectively, stir until completely dissolved, and slowly add the urea solution dropwise to the cerium nitrate solution at 120 ° C, react for 2 hours, and generate dioxide After the cerium nanoparticles are centrifuged, filtered and washed with water for many times, dried and ground to obtain cerium oxide nanoparticles;
[0086] (2) Add CeO to 100 mL of water 2 -NPs (10 g) and APS (2 g), adjust the pH to 4 with dilute sulfuric acid, and continuously stir at 80 °C for 5 h to obtain APS-modified CeO 2 (CeO 2 / APS) solution;
[0087] (3) 5,5-dimethyl hydantoin (12.8 g) and sodium hydroxide (4 g) were stirred in ethanol (100 mL) at room temperature for 30 min, and then ethanol and water were removed by vacuum drying for 2 days to obtain a mixture; Then, epichlorohydrin (9.3 g) and ethanol (10...
Embodiment 2
[0096] A method for preparing 3D printing antibacterial ink, comprising the following steps:
[0097] GelMA, xanthan gum, CMC, photoinitiator Irgacure 2959, and water were mixed uniformly according to the mass ratio of 15:2:8:0.5:100 to obtain the ink solution; then the halamine modified dioxide obtained in Example 1 was mixed Cerium nanoparticles were added to the ink solution and mixed uniformly to obtain the 3D printing antibacterial ink (GCX-CeO 2 / APSGH-Cl); wherein the mass concentration of halamine-modified ceria nanoparticles in the ink solution is 4%.
Embodiment 3
[0098] Example 3 Optimization of hydrogel properties
[0099] Adjustment 1: Optimization of Xanthan Gum
[0100] GelMA, xanthan gum, CMC, photoinitiator Irgacure 2959, and water were mixed uniformly according to the mass ratio of 15:1:8:0.5:100 and 15:3:8:0.5:100 to obtain an ink solution.
[0101] The obtained ink solution is 3D printed, and the parameters of 3D printing are:
[0102] The needle diameter is 0.7mm, the pressure is 180-200kPa, the printing speed is 2mm / s, the lifting height of each layer is 0.5mm, the printing size is 20.0×20.0mm, and the spacing is 1.0mm. The test results of the obtained 3D printing model are as follows:
[0103] The 3D printing ink prepared with a low concentration of xanthan gum (the mass concentration of xanthan gum relative to water is 1%) has poor clarity, and there is no way to form a 3D printing structure with high structural accuracy. However, a high concentration of xanthan gum (the mass concentration of xanthan gum relative to wate...
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