Multi-channel in-vivo pharmacokinetic analysis system based on fluorescence monitoring

An analysis system and multi-channel technology, applied in the fields of fluorescence emission analysis, medical science, and spectral diagnosis.
CN113633261APending Publication Date: 2021-11-12NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Publication Date
2021-11-12

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Abstract

The invention discloses a multi-channel in-vivo pharmacokinetic analysis system based on fluorescence monitoring. The multi-channel in-vivo pharmacokinetic analysis system comprises a light source, a multi-path optical switch, a fluorescence spectrometer, a Y-shaped optical fiber probe group, a control circuit, an operation platform, a dual-channel anesthesia machine and an upper computer. According to the invention, multi-channel real-time in-vivo monitoring can be realized, and more accurate biological data relative to in-vitro data can be obtained; optical fiber arrangement is designed according to a slit of the spectrometer, time division multiplexing is performed on the spectrometer by utilizing switching of an optical switch, and simultaneous monitoring of parts such as different tissues, organs and blood vessels of a small animal by six channels is realized; and different physiological pharmacokinetic models are established for analysis according to in-vivo data of a plurality of tissues on an upper computer, so that more accurate data is provided for metabolism of new drugs, and clinical transformation and application of the new drugs are promoted.
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Description

technical field

[0001] The invention relates to the technical field of nanomedicine medical detection, in particular to a multi-channel in vivo pharmacokinetic analysis system based on fluorescence monitoring. Background technique

[0002] The transport, distribution, and release of nanomedicines in the body are closely related to their curative effects, and are the key to evaluating their clinical transformation. In recent years, the in vivo pharmacokinetic study of small animals based on optical microscopy has become a hot topic in evaluating the druggability of nanomedicines. The high specific surface area and easy surface modification of nanomedicines endow them with various high biological activities, including biomembrane barrier penetration, tissue distribution selectivity, drug release controllability, and membrane transport mechanism transformation. Compared with traditional drugs, nano-drugs have the advantages of long plasma half-life, low clearance rate, and tar...

Claims

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