Multi-channel in-vivo pharmacokinetic analysis system based on fluorescence monitoring

Abstract

The invention discloses a multi-channel in-vivo pharmacokinetic analysis system based on fluorescence monitoring. The multi-channel in-vivo pharmacokinetic analysis system comprises a light source, a multi-path optical switch, a fluorescence spectrometer, a Y-shaped optical fiber probe group, a control circuit, an operation platform, a dual-channel anesthesia machine and an upper computer. According to the invention, multi-channel real-time in-vivo monitoring can be realized, and more accurate biological data relative to in-vitro data can be obtained; optical fiber arrangement is designed according to a slit of the spectrometer, time division multiplexing is performed on the spectrometer by utilizing switching of an optical switch, and simultaneous monitoring of parts such as different tissues, organs and blood vessels of a small animal by six channels is realized; and different physiological pharmacokinetic models are established for analysis according to in-vivo data of a plurality of tissues on an upper computer, so that more accurate data is provided for metabolism of new drugs, and clinical transformation and application of the new drugs are promoted.

Description

technical field [0001] The invention relates to the technical field of nanomedicine medical detection, in particular to a multi-channel in vivo pharmacokinetic analysis system based on fluorescence monitoring. Background technique [0002] The transport, distribution, and release of nanomedicines in the body are closely related to their curative effects, and are the key to evaluating their clinical transformation. In recent years, the in vivo pharmacokinetic study of small animals based on optical microscopy has become a hot topic in evaluating the druggability of nanomedicines. The high specific surface area and easy surface modification of nanomedicines endow them with various high biological activities, including biomembrane barrier penetration, tissue distribution selectivity, drug release controllability, and membrane transport mechanism transformation. Compared with traditional drugs, nano-drugs have the advantages of long plasma half-life, low clearance rate, and tar...

AI Technical Summary

Problems solved by technology

Nowadays, the preparatory work for drug analysis is complicated and cumbersome. One experiment needs to administer drugs to a large number of small animals at the same time. After that, it is necessary to collect plasma from animals and homogenate tissues from various parts in batches at a specific time to detect the inside This is a huge and time-consuming task, and there are problems such as time differences, individual differences between animals, and in vitro data collection.

However, the nuclide detection commonly used in in vivo data analysis has the characteristics of low resolution, can only observe the aggregation state and cannot obtain accurate data, etc.

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