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Bismuth oxide/manganese oxide composite nanosphere, preparation method thereof and application of bismuth oxide/manganese oxide composite nanosphere in psoriasis treatment

A technology of manganese oxide and bismuth oxide, applied in chemical instruments and methods, manganese oxide/manganese hydroxide, bismuth compounds, etc., can solve the problems of oxidative damage of cancer cells, and no preparation of bismuth oxide/manganese oxide composite nanospheres. , to achieve the effects of low production cost, simple synthesis method and uniform product morphology

Active Publication Date: 2021-11-26
ANHUI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Bismuth oxide nanomaterials can chemically dynamically catalyze amplified free radical production leading to oxidative damage to cancer cells
"German Applied Chemistry" (Angewandte Chemie International Edition, doi.org / 10.1002 / anie.202107556) reported a Bi-based modulator (BiO 2-x ), allowing environmentally adaptive free radical catalysis to amplify free radical production through chemical dynamic catalysis, leading to oxidative damage to cancer cells
However, there is no report on the preparation of bismuth oxide / manganese oxide composite nanospheres.

Method used

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  • Bismuth oxide/manganese oxide composite nanosphere, preparation method thereof and application of bismuth oxide/manganese oxide composite nanosphere in psoriasis treatment
  • Bismuth oxide/manganese oxide composite nanosphere, preparation method thereof and application of bismuth oxide/manganese oxide composite nanosphere in psoriasis treatment
  • Bismuth oxide/manganese oxide composite nanosphere, preparation method thereof and application of bismuth oxide/manganese oxide composite nanosphere in psoriasis treatment

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Effect test

Embodiment 1

[0028] In this embodiment, Bi 2 S 3 with KMnO 4 Bismuth oxide / manganese oxide composite nanospheres were prepared with a mass ratio of 1:3:

[0029] Weigh 200mg of rod-shaped Bi 2 S 3 Hollow nanospheres were placed in a 50mL round bottom flask, and 20mL deionized water was added to ultrasonically disperse evenly; weigh 600mg KMnO 4 Place in a 15mL centrifuge tube, add 10mL deionized water and sonicate until completely dissolved, and add Bi 2 S 3 The solution was placed in a round bottom flask and stirred for 20 min.

[0030] Bi 2 S 3 and KMnO 4 The mixed solution was transferred to a 50mL polytetrafluoroethylene-lined reactor and reacted at a temperature of 150°C for 2 hours. After the reaction was completed, it was naturally cooled to room temperature and washed by centrifugation to obtain the target product bismuth oxide / manganese oxide composite nanospheres.

[0031] figure 1 The transmission electron micrograph of the bismuth oxide / manganese oxide composite nano...

Embodiment 2

[0035] In this embodiment, Bi 2 S 3 with KMnO 4 Bismuth oxide / manganese oxide composite nanospheres were prepared under the condition that the mass ratio was 1:2:

[0036] Weigh 200mg of rod-shaped Bi 2 S 3 Hollow nanospheres were placed in a 50mL round bottom flask, and 20mL deionized water was added to ultrasonically disperse evenly; weigh 400mg KMnO 4 Place in a 15mL centrifuge tube, add 10mL deionized water and sonicate until completely dissolved, and add Bi 2 S 3 The solution was placed in a round bottom flask and stirred for 20 min.

[0037] Bi 2 S 3 and KMnO 4 The mixed solution was transferred to a 50mL polytetrafluoroethylene-lined reactor and reacted at a temperature of 150°C for 2 hours. After the reaction was completed, it was naturally cooled to room temperature and washed by centrifugation to obtain the target product bismuth oxide / manganese oxide composite nanospheres.

[0038] Figure 4 The transmission electron micrograph of the composite nanosphere...

Embodiment 3

[0040] In this embodiment, Bi 2 S 3 with KMnO 4 Bismuth oxide / manganese oxide composite nanospheres were prepared under the condition that the mass ratio was 1:4:

[0041] Weigh 200mg of rod-shaped Bi 2 S 3 Hollow nanospheres were placed in a 50mL round bottom flask, and 20mL deionized water was added to ultrasonically disperse evenly; weigh 800mg KMnO 4 Place in a 15mL centrifuge tube, add 10mL deionized water and sonicate until completely dissolved, and add Bi 2 S 3 The solution was placed in a round bottom flask and stirred for 20 min.

[0042] Bi 2 S 3 and KMnO 4 The mixed solution was transferred to a 50mL polytetrafluoroethylene-lined reactor and reacted at a temperature of 150°C for 2 hours. After the reaction was completed, it was naturally cooled to room temperature and washed by centrifugation to obtain the target bismuth oxide / manganese oxide composite material.

[0043] Figure 6 The transmission electron microscope figure of the composite material prepa...

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Abstract

The invention discloses a bismuth oxide / manganese oxide composite nanosphere, a preparation method thereof and application of the bismuth oxide / manganese oxide composite nanosphere in psoriasis treatment. The nanosphere is obtained by taking a rod-like Bi2S3 hollow nanosphere as a precursor and reacting the rod-like Bi2S3 hollow nanosphere with KMnO4 in water. The bismuth oxide / manganese oxide composite nanospheres are synthesized in the mild aqueous solution for the first time, the synthesis method is simple, the reaction conditions are mild, the obtained product is uniform in morphology, the production cost is relatively low, and the method is suitable for industrial amplified production; and the nanosphere obtained by the invention can break an inflammation loop of psoriasis, effectively prevent inflammation recurrence, and realize accurate, effective and long-term treatment of psoriasis.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a bismuth oxide / manganese oxide composite nanosphere, a preparation method thereof and an application in treating psoriasis. Background technique [0002] Bismuth-based nanomaterials have the advantages of ultra-high X-ray attenuation coefficient, good biocompatibility, and low cost. CT diagnostic agent. Bismuth oxide nanomaterials can chemically dynamically catalyze amplified free radical production leading to oxidative damage to cancer cells. "German Applied Chemistry" (Angewandte Chemie International Edition, doi.org / 10.1002 / anie.202107556) reported a Bi-based modulator (BiO 2-x ), allowing environmentally adaptive free radical catalysis to amplify free radical production through chemical dynamic catalysis leading to oxidative damage to cancer cells. Specifically, generation of highly toxic O in cancer cells by modulating catalytic enzymatic rea...

Claims

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Application Information

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IPC IPC(8): A61K33/32A61K33/24A61K9/14A61K47/69A61P17/06C01G29/00C01G45/02B82Y5/00B82Y40/00B82Y30/00
CPCA61K33/24A61K33/32A61K9/14A61P17/06A61K47/6949B82Y5/00B82Y40/00B82Y30/00C01G45/02C01G29/00C01P2004/82C01P2004/04C01P2002/85C01P2004/62C01P2004/34C01P2004/64A61K2300/00
Inventor 钱海生陈本金王婉妮
Owner ANHUI MEDICAL UNIV
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