Photothermal/photodynamic synergistic tumor phototherapy agent and its preparation method and application
A photodynamic and tumor technology, which is applied in the field of materials and biomedicine, can solve problems such as limitation and cell hypoxia, and achieve the effects of increasing lifespan, reducing metal toxicity, and good market prospects
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Embodiment 1
[0041] A method for preparing a photothermal / photodynamic synergistic tumor phototherapy agent, comprising the following steps:
[0042] First, 23 mg Pd(NO 3 ) 2 Add it into 10 mL deionized water, stir well to make a metal palladium salt solution with a metal ion concentration of 0.01 mol / L; add 2.61 μL 3-mercaptopropionic acid to 9997.39 μL deionized water, stir well to make a concentration of 0.003 mol / L 3-mercaptopropionic acid solution; add 0.6 g NaOH to 10 ml deionized water, stir thoroughly to prepare a sodium hydroxide solution with a concentration of 1.5 mol / L; add 4.75 mg NaBH 4 Add it to 2.5ml deionized water, shake well to prepare a sodium borohydride aqueous solution with a concentration of 0.05 mol / L;
[0043] Then, measure 0.25 ml of the above-mentioned metal palladium salt solution and add it to 2.35 ml of deionized water, stir well, then add 2 ml of the above-mentioned 3-mercaptopropionic acid solution and stir for 5 min, then add 0.3 ml of the above-mentione...
Embodiment 2
[0046] A method for preparing a photothermal / photodynamic synergistic tumor phototherapy agent, comprising the following steps:
[0047] First, 46 mg Pd(NO 3 ) 2 Add 12.3 mg of glutathione into 10 mL of deionized water, stir well to prepare a metal palladium salt solution with a metal ion concentration of 0.02 mol / L; / L glutathione aqueous solution; add 0.52 g NaOH to 10 mL deionized water, stir thoroughly to prepare a sodium hydroxide solution with a concentration of 1.3 mol / L; add 7.6 mg NaBH 4 Add to 2.5mL deionized water, shake well to prepare a solution with a concentration of 0.08 mol / L;
[0048] Then, measure 0.25 ml of the above metal palladium salt solution into 2.35 ml of deionized water, stir well, add 2 ml of glutathione solution and stir for 7 min, then add 0.3 ml of the above NaOH solution and stir for 18 min, and finally Add 0.1 ml of the above NaBH 4 The solution was stirred for 12 h; the obtained mixed solution was purified by dialysis in ultrapure water f...
Embodiment 3
[0051] A method for preparing a photothermal / photodynamic synergistic tumor phototherapy agent, comprising the following steps:
[0052] First, 155 mg H 2 Cl 6 Pt was added to 10 mL of deionized water, stirred thoroughly to prepare a metal platinum salt solution with a metal ion concentration of 0.03 mol / L; 4.35 μL of 3-mercaptopropionic acid was added to 9995.65 μL of deionized water, and fully stirred to prepare a solution with a concentration of 0.005 mol / L 3-mercaptopropionic acid solution; add 0.4 g NaOH to 10 mL deionized water, stir well to prepare a sodium hydroxide solution with a concentration of 1.0 mol / L; add 9.5 mg NaBH 4 Add to 2.5mL deionized water, shake well to prepare a solution with a concentration of 0.1 mol / L;
[0053] Then, measure 0.25 mL of the above-mentioned metal platinum salt solution and add it to 2.35 mL of deionized water, stir well, add 2 mL of the above-mentioned 3-mercaptopropionic acid solution and stir for 10 min, then add 0.3 mL of the ab...
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