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Surface enhanced Raman scattering substrate material and preparation method and application thereof

A surface-enhanced Raman and substrate material technology, applied in the field of materials, can solve problems such as strong fluidity, difficult SERS detection, and low gas density, and achieve high activity, simple synthesis process, and high sensitivity

Pending Publication Date: 2021-12-31
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the SERS signal attenuates sharply with the distance between the detected object and the hot spot, the analyte must be quickly adsorbed on the SERS hot spot, and the gas density is low and the fluidity is strong, so it is very difficult to detect with SERS, which prompts us to think How to use a SERS substrate and method that can conveniently and quickly detect markers in exhaled breath

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  • Surface enhanced Raman scattering substrate material and preparation method and application thereof
  • Surface enhanced Raman scattering substrate material and preparation method and application thereof
  • Surface enhanced Raman scattering substrate material and preparation method and application thereof

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preparation example Construction

[0094] According to the method for preparing the above-mentioned surface-enhanced Raman scattering substrate material according to the embodiment of the present invention, firstly, because the hollow structure of the metal-organic framework is conducive to the rapid gas replacement process in the Raman response region, the detection speed of the material for gas molecules is reduced. fast, and due to the enrichment effect of the hollow structure on gas molecules, the adsorption and detection of trace gas molecules can be realized; second, the modified functionalized molecules of the present invention and lung cancer respiratory markers (such as 3-ethylbenzaldehyde, benzene Formaldehyde, salicylaldehyde and glutaraldehyde, etc.) have high binding activity, which can realize the rapid capture of aldehyde molecules, making the surface-enhanced Raman scattering substrate material more sensitive to the above-mentioned respiratory markers of lung cancer, thereby realizing the detectio...

Embodiment 1

[0107] 1) Synthesis of gold superparticles

[0108] Under the protection of inert gas, 0.1gHAuCl 4 ·3H 2 O was added to 20 mL of oleylamine and n-hexane solution (v油胺 :v 正己烷 =1:1), after stirring for 30min at room temperature, quickly add 2mL of borane-tert-butyl complex oleylamine / n-hexane (v 油胺 :v 正己烷 =1:1) mixed solvent, the molar ratio of borane-tert-butyl complex to chloroauric acid is 1:1; after stirring at room temperature for 1 hour, centrifuge at 8000rpm for 5 minutes to collect the purple-red product and wash it with ethanol, Obtain gold nanoparticles; Mix 1mL of the organic phase (5mg / mL) containing gold nanoparticles with 1mL of the aqueous phase (20mg / mL) containing dodecyltrimethylammonium bromide surfactant, and vortex for 1min form microemulsions. At 70°C, the organic phase was removed to form a single-phase suspension of superparticles. 1 mL of the suspension containing the superparticle structure was mixed with 1 mL of a 20 mg / mL protective agent (polyv...

Embodiment 2

[0120] 1) Synthesis of gold superparticles

[0121] Under the protection of inert gas, 0.2gHAuCl 4 ·3H 2 O was added to 50 mL of oleylamine and n-hexane solution, and after stirring at room temperature for 20 min, 2 mL of borane-tert-butyl complex oleylamine / n-hexane (v 油胺 :v 正己烷 =1:1) mixed solvent, the molar ratio of borane-tert-butyl complex to chloroauric acid is 2:1; after stirring at room temperature for 1 hour, centrifuge at 8000rpm for 8 minutes to collect the gray-purple product and wash it with ethanol , to obtain gold nanoparticles; 1 mL of organic phase (5 mg / mL) containing nanoparticles was mixed with 1 mL of aqueous phase (20 mg / mL) containing tetradecyltrimethylammonium bromide surfactant, and vortexed for 2 min form microemulsions. At 60°C, the organic phase was removed to form a single-phase suspension of superparticles. 1 mL of the suspension containing the superparticle structure was mixed with 1 mL of a 10 mg / mL protective agent (polyvinylpyrrolidone w...

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Abstract

The invention discloses a surface enhanced Raman scattering substrate material and a preparation method and application thereof. The substrate material is of a core-shell structure and comprises gold superparticles and a metal organic framework of a hollow structure, and the gold superparticles are arranged in the metal organic framework. A pore exists between the inner surface of the metal organic framework and the outer surfaces of the gold superparticles. The substrate material further comprises a functional modification material, and the functional modification material is combined on the outer surfaces of the gold superparticles through chemical bonds. According to the surface enhanced Raman scattering substrate material and the preparation method and application thereof, rapid gas capture, rapid adsorption, specificity and rapid quantitative detection of lung cancer respiratory markers can be realized.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a surface-enhanced Raman scattering base material and a preparation method and application thereof. Background technique [0002] Some products of human metabolism are carried by the blood to the lungs, where they appear in the exhaled air through gas exchange in the alveoli. The content of volatile organic gases (VOCs) in the exhaled breath of cancer is quite different from that of ordinary people. Among them, aldehyde molecules have been proven to be used as biomarkers for lung cancer patients, and the changes in their content can be used to judge the metabolism of tissue cells. Thus realizing the early diagnosis of lung cancer. At present, VOCs detection and analysis are mainly carried out by solid-phase microextraction combined with gas chromatography-mass spectrometry (GC-MS) technology, thermal desorber combined with gas chromatography, and laser absorption s...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/00G01N21/65B82Y15/00B82Y40/00
CPCB22F9/24B82Y15/00B82Y40/00G01N21/658
Inventor 王铁李艾琳
Owner INST OF CHEM CHINESE ACAD OF SCI
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