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Rare earth biological organic coordination nano-probe synthesized by reversed-phase micro-emulsion method and synthesis method thereof

A reverse-phase microemulsion and nanoprobe technology, applied in the field of materials, can solve the problems of limiting rare earth bioorganic coordination nanoprobes, uncontrollable particle size, and low repeatability, and achieve good monodisperse water solubility and functional realization Good diversity and repeatability

Pending Publication Date: 2021-12-31
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Claims
  • Application Information

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Problems solved by technology

The existing synthesis methods mainly include room temperature stirring method and solvothermal method. These two synthesis methods are simple, convenient, and low in cost, but both have problems such as low reproducibility, uncontrollable particle size, easy crosslinking, and poor stability. , greatly limiting the further biomedical-related applications of rare-earth bioorganic coordination nanoprobes

Method used

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  • Rare earth biological organic coordination nano-probe synthesized by reversed-phase micro-emulsion method and synthesis method thereof
  • Rare earth biological organic coordination nano-probe synthesized by reversed-phase micro-emulsion method and synthesis method thereof
  • Rare earth biological organic coordination nano-probe synthesized by reversed-phase micro-emulsion method and synthesis method thereof

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Embodiment 1

[0044] Coordination polymer nanoprobes with different rare earth centers were prepared by inverse microemulsion method.

[0045] Using rare earth nitrate and adenosine triphosphate as reaction raw materials, cetyltrimethylammonium bromide (CTAB), n-hexanol and isooctane constitute the surfactant, cosurfactant and oil phase of the inverse microemulsion system, The preparation method is as follows:

[0046] 1) Weigh an appropriate amount of adenosine triphosphate (ATP) and Ln (NO 3 ) 3 (Ln=Ce, Sm, Eu, Gd, Tb, Yb) were dissolved in pure water to prepare ATP aqueous solution B and Ln(NO 3 ) 3 Aqueous solution A;

[0047] 2) Prepare two oil phase mixtures with the same volume, which contain isooctane, 0.1 mol / L CTAB and 0.5 mol / L n-hexanol, and add 270 microliters of the above step 1) to the oil phase mixture ATP and Ln(NO 3 ) 3 Aqueous solution, prepared into two groups of mixed solutions with volumes of 10mL each. Wherein the molar ratio W value of aqueous phase and surfa...

Embodiment 2

[0055] Using rare earth nitrate and adenosine triphosphate as reaction raw materials, hexadecyltrimethylammonium bromide, n-hexanol and isooctane constitute the surfactant, co-surfactant and oil phase of the inverse microemulsion system. Microemulsion method, the synthesis method is as follows:

[0056] 1) Weigh an appropriate amount of adenosine triphosphate (ATP) and Ce(NO 3 ) 3 Dissolve in pure water, and prepare ATP aqueous solution B and Ce(NO 3 ) 3 Aqueous solution A.

[0057] 2) Prepare six parts of CTAB (cetyltrimethylammonium bromide), n-hexanol and isooctane oil phase mixture with the same volume respectively.

[0058] The concentrations of CTAB and n-hexanol in each of the six copies are the same and each is a group, divided into three groups A, B, and C; the CTAB concentrations of the three groups A, B, and C are respectively 0.1 mol / L and 0.075 mol / L, 0.05 mol / L; the concentration of n-hexanol is 0.5 mol / L, 0.375 mol / L, 0.25 mol / L, respectively.

[0059] Ad...

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Abstract

The invention discloses a water-soluble rare earth biological organic coordination nano-probe synthesized by using a reversed-phase micro-emulsion and a preparation method thereof. The method comprises the steps of: respectively preparing reversed-phase micro-emulsions containing a rare earth raw material and an organic ligand raw material, mixing the two reversed-phase micro-emulsions, and stirring at a certain temperature for reaction to obtain the nano-probe. The method is simple and easy to implement, has good repeatability and universality, can regulate and control the particle size by adjusting the feeding ratio of a water phase to a surfactant, has good monodisperse water solubility, stability and biocompatibility, and is more beneficial to later analysis and detection and application in the fields of biomedicine and the like. The nano-probe has a loose and porous structure, so that different functional molecules can be further modified or loaded, functional diversity is realized, and the application range of the nano-probe is expanded. The method provides an efficient new method and corresponding technical support for the application of the rare earth biological organic coordination nano-probe in the biomedical fields of biosensing, medical imaging, drug delivery and the like.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a method for synthesizing water-soluble rare earth bioorganic coordination nanometer probes by using reverse-phase microemulsions and a preparation method thereof. Background technique [0002] Rare earth complexes are widely used in the field of biomedical diagnosis and treatment because of their excellent photophysical and chemical properties. However, the poor water solubility and biocompatibility of most rare earth complexes greatly limit their further applications in biology. Rare earth bioorganic coordination nanoprobes have aroused great interest of researchers due to their small size and unique properties. The choice of ligands endows rare earth-organic coordination nanoprobes with structural and functional diversity; the introduction of bioorganic ligands greatly improves the water solubility and biocompatibility of complex nanoprobes, so rare earth bioorganic Coord...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K47/34A61K49/00B82Y30/00B82Y40/00
CPCC08G83/008A61K49/0013A61K47/34B82Y30/00B82Y40/00
Inventor 刘䶮杨颖婕陈学元张云钦涂大涛高航李嘉尧
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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