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Terpolymer, suture line as well as preparation method and application of suture line

A terpolymer and suture technology, applied in the direction of single-component copolyester rayon, melt spinning, filament/thread forming, etc., can solve the problem of preparation of sutures, low tensile modulus of copolymers, etc. problem, to achieve good thermodynamic performance, good degradable performance effect

Active Publication Date: 2022-01-04
广东粤港澳大湾区黄埔材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is a traditional method to prepare poly-L-lactide oligomer as hard phase and poly(glycolide / caprolactone) copolymer as soft phase respectively, and hard phase and soft phase are prepared by coupling method to generate poly-L-lactide. Lactide-poly(glycolide / caprolactone) multi-block copolymer, although the prepared copolymer is biodegradable, the copolymer has a low tensile modulus and cannot be melt-spun to prepare sutures Wire

Method used

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  • Terpolymer, suture line as well as preparation method and application of suture line
  • Terpolymer, suture line as well as preparation method and application of suture line
  • Terpolymer, suture line as well as preparation method and application of suture line

Examples

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preparation example Construction

[0039] An embodiment of the present invention also provides a method for preparing a terpolymer, comprising the following steps S110-S130.

[0040] S110: In terms of mole percentages, weigh 60 mol% to 78 mol% of glycolide, 2 mol% to 20 mol% of L-lactide, and 20 mol% of caprolactone.

[0041] In a specific example, 60mol%-70mol% of glycolide, 10mol%-20mol% of L-lactide and 20mol% of caprolactone are weighed in terms of mole percentage.

[0042] In a specific example, 72mol%-78mol% of glycolide, 2mol%-8mol% of L-lactide and 20mol% of caprolactone are weighed by mole percentage.

[0043] S120: Mix part of glycolide, L-lactide and caprolactone, use stannous octoate as a catalyst, heat and react under negative pressure to form a prepolymer, wherein the amount of part of glycolide is the same as that of caprolactone The ratio of the amount of the substance of the lactone is 45:55˜55:45. Stannous octoate can catalyze the polymerization of glycolide, L-lactide and caprolactone to in...

Embodiment 1

[0067] The ratio of the amount of substances is glycolide: L-lactide: caprolactone = 60mol%: 20mol%: 20mol% of the terpolymer and the preparation of the suture.

[0068] Step 1: Accurately weigh 11.61g glycolide (0.1mol, molecular weight: 116.07g / mol), 14.41g L-lactide (0.1mol, molecular weight: 144.13g / mol), 11.41g caprolactone (0.1mol , molecular weight: 114.14g / mol), 1.8mg1,4-butanediol (0.02mmol, molecular weight: 90.12g / mol), 40.5mg stannous octoate (0.1mmol, molecular weight: 405.1g / mol), the three esters Add monomers, diol initiators and catalysts into the three-necked flask.

[0069] Step 2: Repeatedly inject nitrogen into the three-necked bottle and extract it 5 times. After the extraction, place the three-necked bottle in an oil bath, carry out mechanical stirring and at the same time raise the temperature to 130°C to melt all the ester monomers to a clear and transparent state, and then put the system Raise the temperature to 145°C, and observe the experimental sta...

Embodiment 2

[0074] The ratio of the amount of substances is glycolide: L-lactide: caprolactone = 75mol%: 5mol%: 20mol% terpolymer and suture preparation.

[0075] Step 1: Accurately weigh 4.64g glycolide (0.04mol, molecular weight: 116.07g / mol), 1.44g L-lactide (0.01mol, molecular weight: 144.13g / mol), 4.58g caprolactone (0.04mol , molecular weight: 114.14g / mol), 1.8mg 1,4-butanediol (0.02mmol, molecular weight: 90.12g / mol), 16.2mg stannous octoate (0.04mmol, molecular weight: 405.1g / mol), the three Ester monomers, diol initiators and catalysts are added to the three-necked flask.

[0076] Step 2: Same as Step 2 in Example 1.

[0077] Step 3: Heat up to 170°C to melt the prepolymer, add 12.77g (0.11mol) of the melted glycolide monomer, heat up to 200°C for 2 hours after the mixture is completely melted to obtain a terpolymer, and cool to At room temperature, the three-necked bottle was broken to take out the terpolymer.

[0078] Step 4: Same as Step 4 in Example 1.

[0079] Step 5: Sa...

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Abstract

The invention relates to a terpolymer. The terpolymer is generated by carrying out copolymerization on 60-78 mol% of glycolide, 2-20 mol% of L-lactide and 20 mol% of caprolactone under the catalysis of stannous octoate in percentage by mole. The glycolide, the L-lactide and the caprolactone are subjected to ring opening polymerization to obtain the terpolymer, the terpolymer has good degradability and thermal properties, further, the terpolymer is subjected to melt spinning to obtain a suture line with good mechanical properties, and the suture line is suitable for the field of biomedicine.

Description

technical field [0001] The invention relates to the technical field of absorbable medical materials, in particular to a terpolymer, a suture and a preparation method and application thereof. Background technique [0002] Absorbable medical materials are widely used in wound suturing, lumen ligation, tissue apposition, implant fixation, and wound surface repair. Its chemical composition is mainly biodegradable polymers, which can be degraded into water and carbon dioxide that are non-toxic and harmless to the human body after maintaining the mechanical strength for a certain period of time in the human body, and are excreted through metabolism. [0003] Due to their controllable degradability and good biocompatibility, L-lactide (LLA) and glycolide (GA) have been applied in the fields of drug controlled release, tissue scaffold and bone fixation in some researches. . However, the mechanical properties of their homopolymers (polylactic acid (PLLA), polyglycolic acid (PGA)) a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/06C08G63/78D01F6/84D01D5/098A61L17/12
CPCC08G63/06C08G63/78D01F6/84D01D5/098A61L17/12C08L67/04
Inventor 徐家林凤鹏举范义飞刘逸涵毛秦岑
Owner 广东粤港澳大湾区黄埔材料研究院