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Traditional Chinese medicine extract, composition and application of traditional Chinese medicine extract and composition in preparation of toothpaste or mouth wash with tooth cleaning and solidifying effects

A technology of extracts and compositions, applied in the field of traditional Chinese medicine extracts, toothpaste or mouthwash, and compositions, can solve the problems of unreported anti-streptococcus mutans effects of mint, and achieve prevention or prevention of dental plaque formation and prevention Or dental caries, the effect of reducing dental caries

Active Publication Date: 2022-01-18
MARINE MEDICAL RES INST OF GUANGDONG ZHANJIANG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art also does not report that peppermint or its ingredients have anti-streptococcus mutans effects

Method used

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  • Traditional Chinese medicine extract, composition and application of traditional Chinese medicine extract and composition in preparation of toothpaste or mouth wash with tooth cleaning and solidifying effects
  • Traditional Chinese medicine extract, composition and application of traditional Chinese medicine extract and composition in preparation of toothpaste or mouth wash with tooth cleaning and solidifying effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 Chinese medicine extract

[0036] (1) After mixing 100 g of the traditional Chinese medicine Gardenia jasmine and 50 g of peppermint, heat and reflux extraction with 2.25 L of ethanol aqueous solution with a volume fraction of 40%, after the extraction is completed, the extract is concentrated and dried to obtain the ethanol extract;

[0037] (2) macroporous resin column (filler in macroporous resin column is D101 macroporous resin; the weight consumption of macroporous resin is 40 times of ethanol extract weight) with ethanol extract; First use the volume of 4 times column volume The ethanol solution with a fraction of 8% was used to elute and remove impurities; and then eluted with a volume fraction of 25% ethanol solution of 5 times the column volume, and the fractions eluted with a volume fraction of 25% ethanol solution were collected, concentrated and dried Promptly obtain described Chinese medicine extract afterwards.

Embodiment 2

[0038] The preparation of embodiment 2 compositions

[0039] The traditional Chinese medicine extract prepared in Example 1 was mixed with the tripeptide zinc chelate of A. chinensis in a weight ratio of 4:1.

[0040] The tripeptide zinc chelate of the square starworm is prepared by the following method:

[0041] (1) Pour 250mg of fmoc-Ser(tbu)-OH resin into the reaction column, add DMF to soak for 30min, and drain; then add piperidine DMF solution, shake and filter out the solvent;

[0042] (2) Add an appropriate amount of deprotection solution (piperidine=20% hexahydropyridine+80% DMF) to the reaction column, stir and agitate for 30 minutes with nitrogen, drain, add an appropriate amount of DMF to the reaction column, and agitate for 2 minutes with nitrogen, Drain and repeat the operation 6 times;

[0043] (3) Add Fmoc-Arg(pbf)-OH, condensing agent HBTU and organic base NMM, stir and agitate with nitrogen for 30 minutes, and carry out condensation reaction; wherein, Fmoc-A...

experiment example

[0072] The Oxford cup method was used to test the antibacterial experiment, and the specific method was as follows: add 0.2mL to the culture medium under sterile conditions with a concentration of 1×10 7 Streptococcus mutans solution per mL, spread evenly with an L-shaped smear stick; after drying, put the Oxford cup into the culture medium with tweezers, and then add 200 μL of the drug solution to be tested at a concentration of 0.1g / mL into the Oxford cup , put the petri dish containing the above medium into the incubator, incubate at 37°C for 24 hours, and measure the diameter of the inhibition zone; the larger the diameter of the inhibition zone, the better the antibacterial effect; the drugs in each group were tested 10 times , to calculate the average diameter; the test results are shown in Table 1.

[0073] Table 1. Results of anti-mutans Streptococcus test

[0074]

[0075]

[0076] As can be seen from the experiment in table 1, the Chinese medicine extract prep...

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Abstract

The invention relates to the technical field of biological medicines, and particularly discloses a traditional Chinese medicine extract, a composition and application of the traditional Chinese medicine extract and the composition in preparation of toothpaste or mouth wash with tooth cleaning and solidifying effects. The traditional Chinese medicine extract is prepared from traditional Chinese medicines including fructus gardeniae and herba menthae through ethanol extraction and macroporous resin column elution. The composition comprises the traditional Chinese medicine extract and sipunculus nudus tripeptide or sipunculus nudus tripeptide metal chelate. Researches show that the traditional Chinese medicine extract and the composition have an effect of resisting streptococcus mutans; therefore, the traditional Chinese medicine extract or the composition is used as an active component to be added into the toothpaste or the mouth wash, and an effect of preventing or reducing caries and dental plaque can be achieved; meanwhile, the prepared toothpaste or mouth wash has the tooth cleaning and solidifying effects. In addition, a lucid ganoderma extract is added into the toothpaste or the mouth wash, so that the toothpaste or the mouth wash has multiple antibacterial and anti-protozoan biological effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a traditional Chinese medicine extract, a composition and an application thereof in preparing toothpaste or mouthwash having the effect of cleaning and curing teeth. Background technique [0002] Streptococcus mutans is one of the Streptococcus species with the largest proportion in the natural oral flora, and is one of the main components of dental plaque; at the same time, Streptococcus mutans is also the main bacteria that causes caries. Therefore, inhibiting the growth of Streptococcus mutans is a feasible method to prevent or reduce dental caries and plaque formation. [0003] Shanzhizi is the fruit of the Rubiaceae plant Shanzhi, which is the name of traditional Chinese medicine. Indications: febrile disease upset, liver-fire and red eyes, headache, damp-heat jaundice, stranguria, bloody dysentery, hematuria, sore mouth and tongue, sore swollen toxin, sprain and pain. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K38/06A61P31/04A61P33/02A61P1/02A61K8/64A61K8/9728A61K8/9789A61Q11/00A61K36/074A61K36/534
CPCA61K36/744A61K36/534A61K38/06A61K36/074A61P31/04A61P33/02A61P1/02A61K8/9789A61K8/9728A61K8/64A61Q11/00A61K2300/00
Inventor 戚怡罗辉吕应年李延平欧阳茜茜吴斌华梁力中陈起周
Owner MARINE MEDICAL RES INST OF GUANGDONG ZHANJIANG
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