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Preparation method and application of MPBA@Au-MOF composite material photoelectrochemical sensor

A composite material, photoelectrochemical technology, which is applied in the direction of analysis, scientific instruments, and analytical materials by causing chemical reactions to occur in materials, to achieve the effects of low detection limit, rapid response, and simple preparation process

Pending Publication Date: 2022-01-18
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the determination of SA content using photoelectrochemical and visual dual-functional biosensors using MPBA / SA / MPBA@Au-MOF sandwich sandwich structure composite materials at home and abroad.

Method used

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  • Preparation method and application of MPBA@Au-MOF composite material photoelectrochemical sensor
  • Preparation method and application of MPBA@Au-MOF composite material photoelectrochemical sensor
  • Preparation method and application of MPBA@Au-MOF composite material photoelectrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation process of MOF-Au composite material of the present invention is as follows:

[0049] Preparation of MOF-Au composites

[0050] Mix 600 μL MOF (40 mg / mL) and 1 mL HAuCl 4 (10mg / mL) was added to 250mL purified water in sequence. The above mixture was magnetically stirred for 10 s, and 800 μL of freshly prepared NaBH was quickly added 4 solution (3.8 mg / mL). The synthesized MOF-Au product was centrifuged once with purified water at 10,000 rpm for 15 min to remove unreacted free Au NPs. Subsequently, it was repeatedly washed twice with acetone and once with pure water to remove excess DMF (the aforementioned MOF was prepared with DMF), and finally the product was dispersed into pure water.

[0051] In order to prepare the MOF, 60 mg of zirconium oxychloride, 20 mg of tetra-o-(4-carboxyphenyl) porphyrin (H 2 TCPP) and 580 mg of benzoic acid were added to 20 mL of N,N-dimethylformamide (DMF). The above mixture was stirred at 95°C for 5 hours, centrifuge...

Embodiment 2

[0065] Adopt the ITO / Bi prepared by embodiment 1 2 S 3 The / Au NPs / MPBA / SA / MOF-Au@MPBA composite electrode has been successfully applied to the standard addition method and simple visualization method for the detection of SA in human serum.

[0066] Specific steps are as follows;

[0067] 1) By adding three different concentrations (0.2, 0.5 and 1.0mmol L -1 ) for recovery experiments. In the test solution, human serum is finally diluted 20 times;

[0068] 2) By adding three different concentrations (0.2, 0.5 and 1.0mmol L -1 ) of SA, and visually detect it. In the test solution, human serum is finally diluted 20 times;

[0069] 3) All the other are as in Example 1.

[0070] As can be seen from Table 1, the recovery rate is in the range of 98.0%-100.8%, and the relative standard deviation (n=3) is less than 3%, indicating that the sensor has higher accuracy and precision in detecting SA concentration in human serum biological samples .

[0071] Table 1

[0072]

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Abstract

The invention belongs to the technical field of metal organic framework composite materials, and particularly relates to a preparation method and application of an MPBA@Au-MOF composite material photoelectrochemical sensor, in particular to a method for measuring the content of sialic acid (SA) by adopting a composite material photoelectrochemical and visual bifunction of an MPBA / SA / MPBA@Au-MOF sandwich structure. After the SA is combined with the MPBA, photoelectric signals are converted by giving incident light, and the SA content is detected by observing the change of the electric signals. Meanwhile, due to the fact that the MOF-Au@MPBA composite material has catalytic performance, TMB (colorless) in the electrolyte can be oxidized into oxidation state ox TMB (blue) when incident light is given, and the SA content can be easily judged by observing the color change of the electrolyte. The MPBA@Au-MOF composite material photoelectrochemical sensor can be used for simply, conveniently and quickly detecting the content of SA.

Description

technical field [0001] The invention belongs to the technical field of metal-organic framework composite materials, and in particular relates to a preparation method and application of an MPBA@Au-MOF composite photoelectrochemical sensor. Specifically, the photoelectrochemical and visual dual-functional MPBA@Au-MOF composite sensor was used to detect the content of sialic acid (SA) in serum. Background technique [0002] Metal Organic Frameworks (MOFs) are emerging organic-inorganic hybrid porous solids with potential applications in separation, catalysis, drug delivery, and sensing. In addition, the large specific surface area and tunable pore properties of MOFs have unique advantages over other porous materials, since functional groups can be easily introduced into the framework through ligand design or post-synthesis modification. Therefore, incorporating different functions into MOFs has been extensively studied for various applications. The synthesis methods of MOFs i...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N21/78
CPCG01N27/3277G01N21/78
Inventor 夏莲程圆圆田晓霞张玲东
Owner QUFU NORMAL UNIV
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