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Single-sided adhesion tissue adhesion patch and preparation method thereof

A tissue and patch technology, which is applied in medical formulations, surgical adhesives, operations, etc., can solve the problems of adhesives entering the blood circulation system, unstable adhesion, and hindering the development of tissue adhesive patches, so as to prevent sticking Strong bonding performance, good biocompatibility

Active Publication Date: 2022-01-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there are liquid adhesives with similar functions to tissue patches, which can close tissue wounds after curing, but they are still easily diluted by tissue blood during the curing process, resulting in unstable adhesion, and a large amount of adhesive will enter Disadvantages of the circulatory system
The adhesive patch can close the wound more quickly and stably, but most of the existing adhesive patches are based on the fact that the liquid adhesive retains its incompletely reacted chemical substances and chemically interacts with the tissue surface to achieve The role of strong adhesion, while in vivo use, the toxic effects of degradation metabolism and the additional damage defects caused by adhesion to surrounding normal tissues hinder the further development of tissue adhesive patches

Method used

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  • Single-sided adhesion tissue adhesion patch and preparation method thereof
  • Single-sided adhesion tissue adhesion patch and preparation method thereof
  • Single-sided adhesion tissue adhesion patch and preparation method thereof

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preparation example Construction

[0051] The present invention also provides a preparation method for the above-mentioned tissue adhesive patch, comprising the following preparation steps:

[0052] Prepare a mixed solution A of a zwitterionic polymer monomer and a photoinitiator, and light-initiate polymerization of the mixed solution A to obtain an anti-adhesion layer;

[0053] preparing a mixed solution B of a biocompatible polymer monomer, a toughening agent and a photoinitiator and coating it on the surface of the anti-adhesion layer, and photopolymerizing the mixed solution B to obtain a dissipation layer;

[0054] Prepare tissue-adhesive polymer matrix monomers, photoinitiator mixed solution C and apply it on the surface of the dissipative layer, and light-initiate polymerization of the mixed solution C to obtain a tissue-adhesive layer, thus completing the tissue-adhesive patch preparation.

[0055] In a specific example, the zwitterionic polymer monomer is 2-methacryloyloxyethyl phosphorylcholine, and...

Embodiment 1

[0064] 1) Preparation of anti-adhesion layer: Dissolve 2-methacryloxyethyl phosphorylcholine in deionized water to obtain a 30% (w / v) solution, add 0.1% (w / v) α-ketone Glutaric acid was then applied to a polytetrafluoroethylene mold, and placed under ultraviolet light with a wavelength of 365nm to polymerize for 5 minutes to obtain an anti-adhesion layer with a thickness of about 100 μm.

[0065] 2) Preparation of dissipative layer: Dissolve N-acryloyloxyglycine and isopropylacrylamide in deionized water to obtain mixed solutions with mass fractions of 21% and 9%, respectively, and add 0.1% (w / v) α - After ketoglutaric acid was applied to the surface of the anti-adhesion layer obtained in step 1, it was placed under ultraviolet light with a wavelength of 365 nm for 5 minutes to polymerize to obtain a 200 μm anti-adhesion layer.

[0066] 3) Preparation of tissue adhesion layer: 30% acrylic acid, 1% acrylic acid-N-succinimide ester, 0.5% four-arm polyethylene glycol amino, 0.05%...

Embodiment 2

[0069] The difference from Example 1 is that the mass percentage of the four-arm polyethylene glycol amino group in step 3) is 5%.

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Abstract

The invention discloses a single-sided adhesion tissue adhesion patch and a preparation method thereof. The single-sided adhesion tissue adhesion patch comprises a tissue adhesion layer and a dissipation layer, wherein the tissue adhesion layer is added to any surface of the dissipation layer; the tissue adhesion layer is provided with a tissue adhesion surface and a polymer matrix providing tissue adhesion; the dissipation layer comprises a polymer with biocompatibility and a toughening agent. The single-sided adhesion tissue adhesion patch is high in adhesion performance, and can be quickly adhered to achieve the effects of closing a wound and stopping bleeding after being adhered with tissue; the adhesion patch is only adhered on one side, the content of an active adhesive component is low, the content of an amino acid component is high, and the biocompatibility is good; the back surface of the patch is not adhered, and meanwhile, the patch is not adhered to tissue cells and proteins, so that the postoperative adhesion problem is prevented.

Description

technical field [0001] The invention relates to the technical field of medical patches, in particular to a single-sided adhesive tissue adhesive patch and a preparation method thereof. Background technique [0002] Clinically, tissue trauma wound closure is an inevitable process. Traditional suture surgery will cause secondary damage to the tissue, and the operation time is long, which easily causes infection risks. Tissue-adhesive patch has been gradually paid attention to because of its convenient operation and high efficiency of trauma wound closure without secondary damage. It can replace the application of sutures in some surgical trauma wound closures. However, as a medical implantable tissue adhesive patch, higher requirements are placed on its biocompatibility, such as biocompatibility, biodegradability, and protection of surrounding normal tissues. [0003] In the prior art, there are liquid adhesives with similar functions to tissue patches, which can close tissue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/06
CPCA61L24/001A61L24/06A61L2400/04C08L51/08C08L33/24C08L43/02
Inventor 施雪涛杨卫
Owner SOUTH CHINA UNIV OF TECH
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