Double-sided flexible sensor and preparation method and application thereof

Abstract

The invention provides a flexible sensor. According to the flexible sensor provided by the invention, insulating reinforcing layers are added to the two sides of a flexible substrate layer, and the thicknesses of the substrate layer and the insulating reinforcing layers are accurately controlled, so that the flexible substrate with more excellent performance is prepared, and the flexible substrate can remarkably improve the adhesive force to a conductive layer/electrocatalytic layer, is soft in texture and rich in toughness, improves the overall bending resistance, and is more suitable for preparing the flexible sensor partially implanted into a human body. The flexible base material can be made into a single-piece double-sided flexible electrode, photoetching or screen printing and other technologies are not needed, layer-by-layer assembly insulation treatment is not needed, multi-piece splicing is not needed, compared with a single-piece single-face multi-electrode, the effective working area is larger, the service life of the sensor is prolonged, long-term implantation and use are facilitated, the processing technology can be effectively simplified, the production cost can be reduced, meanwhile, the implantation wound can be effectively reduced through the single-chip electrode structure, and the further prepared flexible sensor is more stable in detection result, small in batch-to-batch difference and high in sensitivity.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to the preparation of an electrochemical biosensor, in particular to a double-sided flexible sensor and its preparation method and application. Background technique [0002] A biosensor is an analytical device for the detection of chemical substances that combines biological components with physicochemical detectors. Biosensors are made of immobilized bioactive molecules as recognition elements (including enzymes, antibodies, antigens, microorganisms, cells, tissues, nucleic acids and other bioactive substances), appropriate physical and chemical transducers (such as oxygen electrodes, photosensitive tubes, field effect sensors, etc.) tube, piezoelectric crystal, etc.) and an analysis tool or system composed of a signal amplification device. [0003] Electrochemical biosensors use solid electrodes as basic electrodes, immobilize bioactive molecules on the electrode surface, and then th...

AI Technical Summary

Problems solved by technology

Existing flexible implantable sensors are usually based on flexible polymer films, on which carbon electrodes are patterned or deposited gold electrodes, and electrochemical detection systems are formed by layer-by-layer assembly or planar dislocation of electrodes. Bending the front wires to reduce the thickness of the final sensor may cause damage to the sensor

Or directly use extremely thin inert metal wires, because the electrode system can only be configured in the radial direction, resulting in a long electrode sensing part

Most of these methods are complicated in process and low in scale, which makes the production cost of this type of product high and expensive.

[0007] CN105943058A discloses a flexible electrode, which adopts electroless plating film on both sides to prepare a two-electrode system without patterning, but because it must be operated by electroless plating and needs to enter platinum black, the sensitivity between batches is different during the detection process , resulting in unstable detection results, and the long-term use of platinum black will cause "catalyst poisoning", that is, the catalytic effect of platinum black is worse than the initial state, thus affecting the detection results

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