Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism

A technology of vascular embolism and gelatin, which is applied in the field of preparation of injectable gelatin-iodol homogeneous preparations for vascular embolism, can solve the problems of inability to improve the loss and loss of lipiodol, incomplete tumor embolization, tumor recurrence, etc., and achieve embolism-enhancing drugs carrying effect

Active Publication Date: 2022-02-11
厦门宏谱福生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when performing this operation, it does not improve the loss of iodized oil that forms milk beads in the blood vessels at the end of the blood vessels.
In addition, due to the mutual adhesion and aggregation of gelatin sponge particles, it is often difficult to reach

Method used

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  • Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism
  • Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism
  • Preparation method and application of injectable gelatin-iodized oil homogeneous preparation for vascular embolism

Examples

Experimental program
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Example Embodiment

[0033] Example 1

[0034] (1) Mix the medical gelatin sponge particles with sterile water, then swelling in a 50 ° C water bath to form liquid gelatin, where gelatin is 20% by weight in sterile water;

[0035] (2) The liquid gelatin obtained by step (1) is added to the autoclave with a volume ratio of 48.0% of the iodine injection of 0.1: 1, pressurized to 20 MPa, temperature control at 50 ° C, to be temperature After the pressure is stable, the holding pressure is stirred for 1 h;

[0036] (3) After the decompression, the blood vessels prepared from the autoclave can be injected into an adhesive-iodine average phase-containing agent.

Example Embodiment

[0037] Example 2

[0038] (1) Mix the medical gelatin sponge particles with a sterile water dissolved with DOX, and then fluid gelatin in a 50 ° C water bath, wherein gelatin is 20% by weight in sterile water, and the concentration of DOX in sterile water is 10mg / ml;

[0039] (2) The liquid gelatin obtained by step (1) is added to the autoclave with a volume ratio of 48.0% of the iodine injection of 0.1: 1, pressurized to 20 MPa, temperature control at 40 ° C, to be temperature After the pressure is stable, the holding pressure is stirred for 1 h;

[0040] (3) After the decompression, the prepared hepatic artery embolization agent was collected from the autoclave.

Example Embodiment

[0041] Example 3

[0042] (1) Mix the medical gelatin sponge particles with a sterile water dissolved with water-soluble drug Rodam, then use a 50 ° C water bath to form liquid gelatin, where gelatin is 20% by weight in sterile water, Rhodamin is not The concentration of the bacteria is 1 mg / ml;

[0043] (2) The liquid gelatin obtained by step (1) is added to the autoclave with a volume ratio of 48.0% of the iodine injection of 0.1: 1, pressurized to 20 MPa, temperature control at 40 ° C, to be temperature After the pressure is stable, the holding pressure is stirred for 1 h;

[0044] (3) After the decompression, the prepared hepatic artery embolization agent was collected from the autoclave;

[0045] (4) Dispersion of fat-soluble pharmaceutical coumarin-6 in step (3) prepared a composite embolization agent, wherein the coumarin-6 has a concentration of 1 mg / mL in the composite embolization agent.

[0046] Compared with the conventional formulation (hand mixing) of the liquid ...

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Abstract

The invention discloses a preparation method of an injectable gelatin-iodized oil homogeneous preparation for vascular embolism. The method comprises the following steps: (1) mixing gelatin with sterile water, and swelling the mixture in a water bath to form liquid-state gelatin; (2) adding the liquid-state gelatin prepared in the step (1) and an iodized oil injection into a high-pressure kettle, pressurizing to 15-25MPa, controlling the temperature at 30-50 DEG C, and after the temperature and the pressure are stable, keeping the temperature and the pressure and stirring for 0.5-2 hours; and (3) after pressure reduction, collecting the prepared injectable gelatin-iodized oil homogeneous preparation for vascular embolism from the high-pressure kettle. According to the preparation prepared by the invention, in a tumor area in a vascular intervention manner, iodized oil can still gather towards the tumor through a siphonic effect while the effects of embolism enhancement and drug carrying can also be achieved.

Description

technical field [0001] The invention belongs to the technical field of hepatic arterial chemoembolization preparations, in particular to a preparation method and application of an injectable gelatin-iodol homogeneous preparation for vascular embolism. Background technique [0002] Liver cancer is one of the most common malignant tumors in my country. The clinical symptoms are relatively hidden in the early stage of the disease. Most patients with liver cancer are already in the middle and late stages when they see a doctor, resulting in the loss of surgery opportunities. Transarterial chemoembolization (TACE) is the first choice for patients with unresectable advanced liver cancer. However, due to the low viscosity and strong fluidity of the commonly used embolic agent, super liquefied lipiodol, it is easy to be flushed by blood, resulting in easy recanalization of blood vessels, and the dual blood supply and multiple collateral circulation of tumors lead to incomplete tumor...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/02A61L24/00A61K9/00A61K47/02A61K47/42A61P35/00
CPCA61L24/0068A61L24/0015A61K9/0019A61K47/42A61K47/02A61P35/00A61L2400/06A61L2300/416C08L89/00
Inventor 刘刚陈虎程红伟张洪瑞高兴
Owner 厦门宏谱福生物科技有限公司
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