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Method for preparing degradable metal molybdenum and alloy for biliary stent

A metal and alloy technology, which is applied in the field of degradable metal molybdenum and alloys for the preparation of biliary tract stents, can solve the problems of low mechanical properties of stents, easy fracture of magnesium stents, and short degradation cycle, so as to promote normal bone metabolism and inhibit osteoclastosis Effects of cell activity and regulation of hormone metabolism in the body

Pending Publication Date: 2022-02-11
SHANDONG RIENTECH MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] In view of this, the present invention provides a method for preparing degradable metal molybdenum and alloys for biliary tract stents, aiming at the problems of low mechanical properties of polymer material stents, easy displacement, easy fracture of magnesium stents, and short degradation cycle.

Method used

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  • Method for preparing degradable metal molybdenum and alloy for biliary stent

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preparation example Construction

[0038] The preparation method for preparing degradable metal molybdenum and alloys of the present invention for biliary stents comprises the following steps:

[0039] According to the mass percentage content, Zn, Fe, Mg, Mo and other small amounts of functional alloying elements are uniformly mixed in a ball mill, smelted in vacuum melting, and subjected to heat treatment, drawing, cutting, polishing, spraying and other processes to obtain the biliary tract stent.

Embodiment 1

[0041] Embodiment 1: Alloy 1-molybdenum-zinc-iron-magnesium quaternary alloy

[0042] The material of degradable metal molybdenum and alloy used in the biliary tract stent in this embodiment is a molybdenum-zinc-iron-magnesium alloy, and the preparation process specifically includes the following steps:

[0043] Ball milling: Weigh high-purity (99.99%) 0.3wt%Zn, 0.5wt%Fe, 0.2wt%Mg and 99wt%Mo powders (R≤30μm) according to a certain mass ratio. Mix the weighed powder evenly in a high-energy ball mill, and the mass ratio of ball to material is 10:1. Vacuumize the ball milling tank with the powder in turn with a vacuum pump, and then pass in argon to fill the whole ball milling tank. The operation mode of the ball mill was set to run forward and reverse alternately at intervals, the speed was 400-600 r / min, and the total time of ball milling was 10-48 h.

[0044] Vacuum melting: Repeated vacuuming 2-4 times to 6×10 -2 Pa-5×10 -3 Pa, close the valve of the furnace body, and th...

Embodiment 2

[0049] Embodiment 2: Alloy 2-molybdenum-zinc-iron-magnesium quaternary alloy

[0050] The material of degradable metal molybdenum and alloy used in the biliary tract stent in this embodiment is a molybdenum-zinc-iron-magnesium alloy, and the preparation process specifically includes the following steps:

[0051] Ball milling: Weigh high-purity (99.99%) 17wt%Zn, 15wt%Fe, 13wt%Mg, 55wt%Mo powder (R≤30 μm) according to a certain mass ratio. Mix the weighed powder evenly in a high-energy ball mill, and the mass ratio of ball to material is 10:1. Vacuumize the ball milling tank with the powder in turn with a vacuum pump, and then pass in argon to fill the whole ball milling tank. The operation mode of the ball mill was set to run forward and reverse alternately at intervals, the speed was 400-600 r / min, and the total time of ball milling was 10-48 h.

[0052] Vacuum melting: Repeated vacuuming 2-4 times to 6×10 -2 Pa-5×10 -3 Pa, close the valve of the furnace body, and then mel...

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Abstract

The invention discloses a method for preparing a degradable metal molybdenum and alloy for a biliary stent, and the alloy comprises the following components, by mass: 0.3-17wt% of Zn, 0.5-15wt% of Fe, and 0.2-13wt% of Mg; at least one of degradable functional elements such as Ca, K, Na, Rb, Sr, Sn, Ba, Mn, Li, Cs, Y and the like is selected, the total amount of added alloy elements is optimally controlled to be not larger than 5 wt%, then elements such as C, Ti, Zr, Ca, Ta and the like are selected, the total amount of the elements is not larger than 5 wt%, and the balance metal is Mo. Mo, Zn, Fe, Mg and other elements are uniformly mixed, and vacuum arc melting is carried out to prepare a product. The molybdenum-based alloy has good mechanical properties and is easy to process, the strength, toughness, shaping and other properties meet the requirements of human body implant materials for biliary tracts and the like, and the surface of the stent is coated with antibacterial, anti-calculus, anti-cancer and other macromolecular drugs. The molybdenum-based alloy biliary stent has good biological performance, and the degradation process and the product are safe and effective to the matrix.

Description

technical field [0001] The invention belongs to the field of medical devices and relates to a method for preparing degradable metal molybdenum and alloys for biliary tract stents. Background technique [0002] The biliary system has the functions of secreting, storing, concentrating and transporting bile, and plays an important role in regulating the discharge of bile into the duodenum. Hepatobiliary system disease is one of the common diseases that seriously threaten human life and health. In recent years, the incidence of biliary tract has been increasing year by year. Common clinical hepatobiliary system diseases such as gallbladder cancer, pancreatic cancer, liver cancer, ampullary tumor, etc. are often accompanied by distal Malignant biliary obstruction occurs, resulting in poor drainage of bile, which in turn leads to complications such as obstructive jaundice. [0003] Under the premise that the tumor cannot be surgically removed, the most mature treatment for malign...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C27/04C22C1/02C22F1/18B22D18/06B22F9/04C25F3/26B23P15/00B23K26/362B23K26/70A61L31/02A61L31/08A61L31/14A61L31/16
CPCC22C27/04C22C1/02C22F1/18B22D18/06C25F3/26B22F9/04B23P15/00B23K26/362B23K26/702A61L31/022A61L31/08A61L31/148A61L31/16A61L2300/606A61L2300/416A61L2300/404B22F2009/043
Inventor 张海军周广泰周超初同超
Owner SHANDONG RIENTECH MEDICAL TECH