Dual-response nano composite hydrogel, preparation method and application thereof

A nano-composite, dual-response technology, used in pharmaceutical formulations, medical preparations with non-active ingredients, aerosol delivery, etc., can solve problems such as poor compressive strength, unsatisfactory drug controlled release, and achieve good thermal stability. , the effect of increasing the low critical solution temperature and enhancing the tensile strength

Active Publication Date: 2022-02-18
GUANGDONG HUAMEI ZHONGYUAN BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current research is mostly on hydrogels with dual responsiveness to pH and temperature, but there are technical problems such as poor compressive strength and unsatisfactory controlled release of drugs, which need to be solved urgently.

Method used

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  • Dual-response nano composite hydrogel, preparation method and application thereof
  • Dual-response nano composite hydrogel, preparation method and application thereof
  • Dual-response nano composite hydrogel, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing a dual-response nanocomposite hydrogel, comprising the steps of:

[0032] S1. Add 1g of sodium alginate to 50g of deionized water and stir evenly. Under nitrogen protection, add 1g of N-isopropylacrylamide and 1g of N-methylolacrylamide and stir evenly. Add 0.01g of nitrogen nitrogen methylenebisacrylamide , 0.01g of sodium persulfate, adjust the temperature of the system to 20°C and stir for 1 hour to obtain a polyacrylamide-sodium alginate compound;

[0033] S2. Dissolve 0.1g of glycidyl ether in 3g of dimethyl sulfoxide under nitrogen protection, continue to stir, add 1g of fumaric acid during the stirring process, stir vigorously for 1h at a stirring speed of 1000r / min, and then pour it into 20g of ether Continue to stir for 1h, let stand for 3h, remove the ether, and spin evaporate to obtain the fumaric acid-glycidyl ether complex;

[0034] S3. Add 0.1 g of transglutaminase solution with a concentration of 20 U / mL to 4 g of polyacrylamide-so...

Embodiment 2

[0036] A method for preparing a dual-response nanocomposite hydrogel, comprising the steps of:

[0037] S1. Add 5g of sodium alginate to 100g of deionized water and stir evenly. Under nitrogen protection, add 4g of N-isopropylacrylamide and 2g of N-methylolacrylamide and stir evenly. Add 0.02g of nitrogen nitrogen methylenebisacrylamide , 0.02g potassium persulfate, adjust the temperature of the system to 30°C and stir for 2h to obtain polyacrylamide-sodium alginate complex;

[0038] S2. Under the protection of nitrogen, dissolve 0.5g glycidyl ether in 6g dimethyl sulfoxide, continue to stir, add 2g fumaric acid during the stirring process, stir vigorously for 2h, the stirring speed is 2000r / min, and then pour it into 40g ether Continue to stir for 2h, let stand for 6h, remove the ether, and spin evaporate to obtain the fumaric acid-glycidyl ether complex;

[0039] S3. Add 0.2 g of transglutaminase solution with a concentration of 60 U / mL to 10 g of polyacrylamide-sodium algi...

Embodiment 3

[0041] A method for preparing a dual-response nanocomposite hydrogel, comprising the steps of:

[0042] S1. Add 1.5g of sodium alginate to 90g of deionized water and stir evenly. Under nitrogen protection, add 1.5g of N-isopropylacrylamide and 1.8g of N-methylolacrylamide and stir evenly. Add 0.011g of nitrogen nitrogen methylene Bisacrylamide, 0.017g ammonium persulfate, adjust the system temperature to 22°C and stir for 1.8h to obtain polyacrylamide-sodium alginate complex;

[0043]S2. Dissolve 0.15g glycidyl ether in 5g dimethyl sulfoxide under the protection of nitrogen, keep stirring, add 1.2g fumaric acid during the stirring process, stir vigorously for 1.9h, the stirring speed is 1200r / min, and then pour it into 35g Continue to stir in ether for 1.2h, let stand for 5h, remove ether, and rotary evaporate to obtain fumaric acid-glycidyl ether complex;

[0044] S3. Add 0.18 g of transglutaminase solution with a concentration of 30 U / mL to 6 g of polyacrylamide-sodium algi...

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Abstract

The invention discloses a dual-response nano composite hydrogel. The invention discloses a preparation method of the dual-response nano composite hydrogel. The method comprises the following steps: adding sodium alginate into deionized water, uniformly stirring, adding N-isopropylacrylamide and N-hydroxymethyl acrylamide under the protection of nitrogen, uniformly stirring, adding nitrogen-nitrogen methylene bisacrylamide and persulfate, adjusting the temperature of the system to 20-30 DEG C, and stirring for 1-2 hours, to obtain a polyacrylamide-sodium alginate compound; dissolving glycidyl ether in dimethyl sulfoxide under the protection of nitrogen, continuously stirring, adding fumaric acid in the stirring process, violently stirring, then pouring into diethyl ether, continuously stirring, standing, removing diethyl ether, and carrying out rotary evaporation to obtain a fumaric acid-glycidyl ether compound; and adding a transglutaminase solution into the polyacrylamide-sodium alginate compound, stirring at a high speed, adding the fumaric acid-glycidyl ether compound in a stirring state, continuously stirring, standing at room temperature, soaking in water to remove unreacted small molecules, and drying in vacuum to obtain the dual-response nano composite hydrogel.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a dual-response nanocomposite hydrogel and its preparation method and application. Background technique [0002] Traditional drug administration methods such as tablets, capsules, and injections have large fluctuations in drug concentration after administration and limited use time. Only frequent small doses are administered, which causes great changes to patients. Smart hydrogels can automatically sense changes in the temperature and chemical environment around the lesion, and automatically release the required amount of drugs. Drug molecules can be bonded in the gel network through physical embedding or co-polymerization, and when the conditions are suitable, the active ingredients of the drug are released. When the conditions are not suitable, the hydrogel is closed and the drug cannot be released. As a drug carrier, smart hydrogel can reduce the number of times of taking m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/04C08L33/24C08K5/1515A61K9/06A61K47/12A61K47/22A61K47/32A61K47/36
CPCC08J3/075A61K9/06A61K47/36A61K47/32A61K47/12A61K47/22C08J2333/24C08J2405/04C08J2305/04C08J2433/24C08K5/1515Y02A50/30
Inventor 徐春涛杜蔚安郑阳阳张丽霞黄茜
Owner GUANGDONG HUAMEI ZHONGYUAN BIOLOGICAL SCI & TECH
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