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Application of cationic polymer in preparation of drugs for removing intestinal microbial toxins and treating tumors

A technology of intestinal microorganisms and cationic polymers, which can be used in the field of medicine to solve problems such as drug resistance

Active Publication Date: 2022-03-01
SQ BIOPHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since gemcitabine is already used in advanced pancreatic cancer, they hypothesized that the presence of this bacterium might lead to resistance to the drug

Method used

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  • Application of cationic polymer in preparation of drugs for removing intestinal microbial toxins and treating tumors
  • Application of cationic polymer in preparation of drugs for removing intestinal microbial toxins and treating tumors
  • Application of cationic polymer in preparation of drugs for removing intestinal microbial toxins and treating tumors

Examples

Experimental program
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Effect test

Embodiment 1

[0092] The preparation and clinical application of the high-molecular cationic polymer of the present invention include treating, alleviating and preventing pancreatic cancer and other cancers, including their various complications. As an example of implementation, it includes amine polymer; its preferred practical application is polystyrene quaternary ammonium salt, cholestyramine (cholestyramine, referred to as "polyaniline"). Repeating units derived from the polymerization of linked monomers, such as polystyrene quaternary ammonium salt ([4-[3-(4-ethylphenyl)butyl]phenyl]-trimethylazanium), whose molecular formula is C 21 h 30 N+, including its various derivative structures, such as modified polyallylamine, copolymerof diethylenetriamine, (C 4 h 10 N 3 ) m (C 3 h 6 O) n ). Its molecular mass (molecular mass) exceeds 1x10 6 g / mol. The general formula of its molecular structure is as follows:

[0093]

[0094] The cationic resin can be taken orally alone, or adde...

Embodiment 2

[0096] The preparation and clinical application of the high-molecular cationic polymer of the present invention include treating, alleviating and preventing pancreatic cancer and other cancers, including the complications of these cancers. As an example of implementation, amine polymers are included. As the preferred application, Colestipol (Colestipol, hydrochloride, Epichlorhydrin-tetraethylenepentamine polymer, CAS No.37296-80-3; SDS CAS No:37296-80-3; Molecular Weight: (225.765) n; Molecular Formula: C 8 h 24 CLN5), or similar cation-rich polymers.

[0097] Its molecular mass (molecular mass) exceeds 1x10 6 g / mol. The general formula of its molecular structure is as follows:

[0098] Colestipol molecular formula: (C 4 h 10 N 3 ) m (C 3 h 6 O) n .

[0099] Its molecular structure general formula is as follows:

[0100]

[0101] Therefore, the high-molecular-weight cationic polymer can be used for the treatment, prevention of said diseases, and the alleviatio...

Embodiment 3

[0104] Colesevelam is another high-molecular cationic polymer, and its bile acid binding capacity is 7 times that of cholestyramine. Based on the similarity of its mechanism, we speculate that oral administration of colesevelam can also reduce the endotoxin produced by intestinal cells and the endotoxin in the blood, thereby reducing the systemic inflammation of the body, restoring insulin sensitivity, reducing fatty liver, and promoting Self-ablation of NASH and cirrhosis. The daily dosage can be viewed as 3.75g, which can be administered in powder or tablet form. The molecular formula of colesevelam is C 31 h 67 Cl 3 N 4 o ; International Union of Pure and Applied Chemistry (IUPAC) named: 2-(chloromethyl)oxirane; prop-2-en-1-amine; N-prop-2-enyldecan-1-amine; trimethyl-[6-(prop -2-enylamino)hexyl]azanium; chloride; hydrochloride.

[0105]

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Abstract

The invention relates to the field of medicines, in particular to application of a cationic polymer in preparation of medicines for treating or preventing tumors. By oral administration of the cationic polymer, various cancers can be relieved, treated and prevented, and complications of the cancers can be relieved. By oral administration of the cationic polymer, metabolites generated by intestinal microorganisms can be effectively removed or eliminated, endotoxin generated by bacteria can be removed, endotoxin entering blood can be reduced, bacterial CpG-DNA entering blood can be reduced, and bacterial flagellin entering blood can be reduced. The preparation can reduce systemic inflammation of a human body and inflammation of a tumor environment, can improve a tumor immune environment, activates cell autophagy to inhibit growth and metastasis of tumors, and reduces tissue fibrosis including liver cirrhosis and pancreatic fibrosis. The cationic polymer which is not decomposed and absorbed by the digestive tract can also be used in combination with other anti-tumor therapies; the traditional Chinese medicine composition is combined with radiotherapy, chemotherapy and immunotherapy to improve the curative effect and tolerance.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of oral cationic polymers in the preparation of drugs for removing various toxins in the intestinal tract to treat or prevent tumors. Background technique [0002] Incidence of pancreatic cancer. Worldwide, the incidence of cancer increases by 19 million people every year, and pancreatic cancer increases by 460,000 people every year. In 2015 alone, there were approximately 90,100 new cases of pancreatic cancer and 79,400 deaths from pancreatic cancer in China. The 5-year survival rate of patients with pancreatic cancer worldwide is approximately 6%. Pancreatic cancer ranks as the 14th most common cancer and the 7th cause of cancer death in the world. The exact cause of pancreatic cancer is unknown. Risk factors include diabetes, chronic pancreatitis, and gastric ulcers. There are no obvious symptoms in the early stage of pancreatic cancer, but weight loss and abdomina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61P1/00A61P29/00A61P35/00A61P3/10A61P1/16A61P1/18
CPCA61K31/785A61P1/00A61P29/00A61P35/00A61P3/10A61P1/16A61P1/18Y02A50/30
Inventor 韩源平赵光夫
Owner SQ BIOPHARMA INC
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