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Cerium oxide reduced graphene oxide nano composite material with various bio-enzyme simulation activities as well as preparation method and application of cerium oxide reduced graphene oxide nano composite material

A nanocomposite material and graphene technology, applied in the field of biomedicine, can solve the problems of loss of enzyme activity, cumbersome and complicated process, and weak enzyme immobilization

Active Publication Date: 2022-03-01
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In traditional methods, enzymes or nanoparticles are often loaded on the surface of graphene oxide by physical adsorption, covalent grafting, and solvothermal methods. Disadvantages such as weak enzyme immobilization

Method used

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  • Cerium oxide reduced graphene oxide nano composite material with various bio-enzyme simulation activities as well as preparation method and application of cerium oxide reduced graphene oxide nano composite material
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  • Cerium oxide reduced graphene oxide nano composite material with various bio-enzyme simulation activities as well as preparation method and application of cerium oxide reduced graphene oxide nano composite material

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Embodiment

[0039] A. Preparation of Graphene Oxide

[0040] Add 69mL concentrated sulfuric acid to 3g graphene flakes, add 1.5g NaNO 3, mix well and cool to 0°C. Then gradually add 9g KMnO 4 , in KMnO 4 The temperature was kept below 20 °C during the addition of . After the addition, the temperature of the reaction system was raised to 35° C., and the stirring was continued for 30 minutes, and then 138 mL of deionized water was slowly added, and the temperature of the reaction system rose during the addition of the deionized water. Continue to raise the temperature of the reaction system to 98° C., stir for 15 minutes, and then cool in a water bath for 10 minutes. Finally, add 420 mL of water and 3 mL of 30% H 2 o 2 The solution was cooled to room temperature in air. The reaction solution was centrifuged and the bottom precipitate was collected. The bottom precipitate was washed with water and ethanol several times, and freeze-dried for 48 hours to obtain graphene oxide for futur...

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Abstract

The invention discloses a cerium oxide reduced graphene oxide nano composite material with various bio-enzyme simulation activities as well as a preparation method and application of the cerium oxide reduced graphene oxide nano composite material. The nano composite material comprises graphene oxide serving as a carrier and nano CeO2-x particles loaded on the surface of the graphene oxide carrier in situ, wherein x is greater than or equal to 0 and less than or equal to 0.5. Compared with pure GO, the cerium oxide reduced graphene oxide nano composite material can regulate and control oxygen-containing functional groups on the surface of the nano composite material, so that the GO superoxide dismutase simulation activity is improved, and the GO is endowed with the catalase simulation activity of antioxidant protection.

Description

technical field [0001] The invention relates to a cerium oxide-reduced graphene oxide nanocomposite material with multiple biological enzyme-mimicking activities, a preparation method and application thereof, and belongs to the field of biomedical technology. Background technique [0002] Graphene is a single-layer sheet-like structure material composed of carbon atoms (sp2 hybridization). Graphene oxide is an oxygen-containing derivative of graphene. Its structure is similar to graphene, and its interlayer, edge or surface contains a large number of active groups such as carboxyl, hydroxyl and epoxy groups. The unique structure of graphene oxide and a large number of oxygen-containing functional groups on its surface make it exhibit many excellent properties. For example, graphene oxide was found to have intrinsic peroxidase and superoxide dismutase mimicking activities. in H 2 o 2 Under the condition of existence, graphene oxide can catalyze the oxidation of colorless ...

Claims

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Application Information

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IPC IPC(8): C01B32/194C01F17/10C01F17/235B82Y40/00B82Y30/00A61K33/24A61K33/00A61K47/04A61P31/04A61P35/00A61P39/06B82Y5/00G01N33/543
CPCC01B32/194C01F17/235C01F17/10B82Y30/00B82Y40/00A61K33/244A61K33/00A61K47/02A61P31/04A61P35/00A61P39/06B82Y5/00G01N33/543C01P2004/80C01P2002/72C01P2004/04C01P2004/64C01P2004/20C01P2006/80C01P2002/85A61K2300/00
Inventor 李恺邵丹丹刘诗伟谢有桃郑学斌
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI