Medical liquid dressing as well as preparation method and application thereof

A technology of liquid dressing and linoleic acid, which is applied in the field of medicine, can solve the problems of exacerbation of the disease, protracted healing, and large skin irritation, and achieve the effects of repairing the skin, accelerating the renewal of epidermal cells, and promoting protein synthesis

Active Publication Date: 2022-03-15
NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these high-molecular compounds are highly irritating to the skin, especially to the skin of infants and young children, but it will aggravate the condition, and there is a risk of developing chronic eczema and protracted healing

Method used

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  • Medical liquid dressing as well as preparation method and application thereof
  • Medical liquid dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A medical liquid dressing includes emulsion type liquid composed of linoleic acid, linolenic acid and four kinds of amino acids.

[0030] The mass-volume ratio of the high-molecular fatty acid and four kinds of amino acids in the liquid dressing is 42.5%.

[0031] Linoleic acid 12.5%, linolenic acid 7.5%, glycine 12%, L-proline 6%, L-lysine 2.5%, L-leucine 2%, sodium hyaluronate 2%, carboxymethyl cellulose Vegetarian sodium 5%, poloxamer 10%, pH adjuster 1.5%, flavoring agent 0.1%, antioxidant 0.5% and preservative 0.1%. The balance of purified water or water for injection.

[0032] The pH adjusting agent is citric acid and disodium hydrogen phosphate. Use 0.1mol / L citric acid and 0.2mol / L disodium hydrogen phosphate to form a citric acid-disodium hydrogen phosphate buffer solution (volume ratio 1:1) The average molecular weight of sodium hyaluronate is about 200,000 Da; the flavoring agent is almond volatile oil; the antioxidant is vitamin E; the preservative uses so...

Embodiment 2

[0039] A medical liquid dressing includes emulsion type liquid composed of linoleic acid, linolenic acid and four kinds of amino acids.

[0040] The mass-volume ratio of the high-molecular fatty acid and four kinds of amino acids in the liquid dressing is 54%.

[0041] Linoleic acid 15%, linolenic acid 10%, glycine 14%, L-proline 8%, L-lysine 4%, L-leucine 3%, sodium hyaluronate 4.5%, carboxymethyl cellulose Vegetarian sodium 8%, poloxamer 15%, pH adjuster 1.5%, flavoring agent 0.3%, antioxidant 1% and preservative 0.3%. The balance of purified water or water for injection.

[0042] The pH adjusting agent is citric acid and disodium hydrogen phosphate. Use 0.1mol / L citric acid and 0.2mol / L disodium hydrogen phosphate to form a citric acid-disodium hydrogen phosphate buffer solution (volume ratio 1:1) The average molecular weight of sodium hyaluronate is about 200,000 Da; the flavoring agent is almond volatile oil; the antioxidant is vitamin E; the preservative uses sodium be...

Embodiment 3

[0049] A medical liquid dressing includes emulsion type liquid composed of linoleic acid, linolenic acid and four kinds of amino acids.

[0050] The mass-volume ratio of the sum of high-molecular fatty acid and four kinds of amino acids in the liquid dressing is 47.5%.

[0051] Linoleic Acid 13.5%, Linolenic Acid 8.5%, Glycine 12.5%, L-Proline 7%, L-Lysine 3.5%, L-Leucine 2.5%, Sodium Hyaluronate 4%, Carboxymethyl Fiber Vegetarian sodium 7%, poloxamer 10%, pH adjuster 1%, flavoring agent 0.1%, antioxidant 0.5% and preservative 0.3%. The balance of purified water or water for injection.

[0052] The pH adjusting agent is citric acid and disodium hydrogen phosphate. Use 0.1mol / L citric acid and 0.2mol / L disodium hydrogen phosphate to form a citric acid-disodium hydrogen phosphate buffer solution (volume ratio 1:1) The average molecular weight of sodium hyaluronate is about 200,000 Da; the flavoring agent is almond volatile oil; the antioxidant is vitamin E; the preservative us...

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Abstract

The invention belongs to the technical field of medicines, and relates to a medical liquid dressing as well as a preparation method and application thereof, in particular to a medical liquid dressing containing linoleic acid, linolenic acid and part of amino acid and application of the medical liquid dressing in preparation of medical dressings for repairing skin injury caused by infant eczema. The liquid dressing provided by the invention takes high-molecular fatty acid and amino acid as main components, wherein the high-molecular fatty acid is two or more of oleic acid, linoleic acid, linolenic acid and docosahexaenoic acid; the amino acid is selected from several of glycine, proline, lysine, leucine, alanine, arginine, hydroxyproline and hydroxylysine; wherein the mass ratio of the macromolecular fatty acid to the amino acid is (0.6-1.2): 1, and the mass ratio of the linoleic acid to the linolenic acid is (1.5-2.0): 1. The medical liquid dressing disclosed by the invention is used for treating and nursing skin injury caused by dermatitis, eczema and ulcer, especially skin injury caused by infant eczema.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medical liquid dressing and its preparation method and application, in particular to a medical liquid dressing containing linoleic acid, linolenic acid, and some amino acids and a method for preparing and repairing skin damage caused by eczema in infants and young children. Application in medical dressings. Background technique [0002] Eczema in infants and young children is an inflammatory skin disease of the epidermis. The etiology is relatively complicated, usually related to allergies, and often accompanied by skin papules, ulcers, ulcers and injuries. The diseased sites are mostly on the face, behind the ears, buttocks, trunk and extremities. At present, there is no specific treatment for infantile eczema, and glucocorticoids and antihistamines are often used, which can temporarily relieve symptoms. However, due to the imperfect immune function of infants and young child...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0023A61L2300/214A61L2300/22A61L2300/41A61L2300/412A61L2300/45A61L2300/236C08L5/08
Inventor 郑大勇张春腾汤红玉严素玉
Owner NORTH CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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