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Micro-droplet manipulation method and device based on ultrahigh frequency bulk acoustic wave resonator

A bulk acoustic wave resonator and microdroplet technology, applied in the field of microfluidics, can solve the problems of poor biocompatibility, limited application range, low mixing efficiency, etc., and achieve good biocompatibility, wide application range and good thermal stability. Effect

Active Publication Date: 2022-03-15
TIANJIN UNIV
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  • Claims
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AI Technical Summary

Problems solved by technology

The magnetic method uses a magnetic field to mix the magnetic particles in the micro-droplets to achieve the mixing of the micro-droplets. In addition, the magnetic particles can be tracked, but there are requirements for the magnetic permeability of the solid particles in the micro-droplets, and the mixing efficiency Low, inconvenient to operate, limited scope of application
The thermal method is to generate a temperature gradient inside the micro-droplet by means of electric heating wire heating, so as to realize the movement of the fluid and complete the mixing of the micro-droplet, but the heating method has a destructive effect on the sample in the micro-droplet, and the biocompatibility is poor. Unable to precisely manipulate solid particles

Method used

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  • Micro-droplet manipulation method and device based on ultrahigh frequency bulk acoustic wave resonator
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  • Micro-droplet manipulation method and device based on ultrahigh frequency bulk acoustic wave resonator

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experiment example

[0062] The size of the microchannel is 150 μm in width and 50 μm in height. The continuous phase of the micro-droplets is a fluorine-containing oil phase, and the dispersed phase is 50% water and 50% ethylene glycol, and the continuous flow micro-droplets are generated by a flow rate of 3:1 μL / min. The four faces of the microdroplet are bounded by microchannels. A thin-film bulk acoustic resonator is arranged in the micro-channel, the entire area of ​​the resonator is located in the micro-channel, and the micro-droplet can cover the entire resonator. The microdroplets are mixed. When the micro-droplet flows over the resonator, the resonator can realize the mixing inside the micro-droplet. When the resonator power is applied to 400mW, sufficient mixing (mixing index > 0.9) can be achieved.

[0063] The inventor also conducted a series of comparative experiments using different parameter conditions, and found that the smaller the flow velocity and viscosity of the micro-dropl...

Embodiment

[0087] The size of the microchannel is 150 μm in width and 50 μm in height. The continuous phase of the micro-droplets is the fluorine-containing oil phase, and the dispersed phase is water. The flow rate of 3:1 μL / min produces continuous-flow micro-droplets, and the four sides of the micro-droplets are bound by the micro-channels. The diameter of the micro-droplet is smaller than the side length of the resonator. The impedance of continuous phase sound is about 8.96*10 5 N·s / m 3 , the dispersed phase acoustic impedance is about 1.48*10 6 N·s / m 3 . A thin-film bulk acoustic resonator is configured in the micro-channel, and micro-droplets can cover the whole or part of the resonator.

[0088] The inventor also carried out a series of comparative experiments using different parameter conditions, and found that the greater the power of the resonator, the smaller the flow velocity of the micro-droplets, the greater the difference between the acoustic impedance of the continuo...

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Abstract

The invention discloses a micro-droplet manipulation method and device based on an ultrahigh frequency bulk acoustic wave resonator. The manipulation method comprises the following steps: providing a continuous phase fluid and micro-droplets dispersed in the continuous phase fluid; the ultrahigh frequency bulk acoustic wave resonator provides bulk acoustic waves and initiates fluid vortices to manipulate the micro-droplets. The control device comprises a micro-droplet generation module, a micro-channel, a downstream channel and an ultrahigh frequency bulk acoustic wave resonator. The manipulation comprises internal substance mixing, micro-droplet fusion, micro-droplet cutting, micro-droplet trajectory control, internal particle trajectory control and the like. The method has the advantages of simplicity, feasibility, multiple functions, wide application range and the like.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a micro droplet manipulation method and device based on an ultra-high frequency bulk acoustic wave resonator. Background technique [0002] Microfluidic manipulation technology refers to the manipulation of micro-droplet movement and material mixing and subsequent biochemical reactions. Droplet microfluidics has the characteristics of high throughput, monodispersity, no cross-contamination, and less reagent consumption. In biochemical reactions, it has unique advantages as a micro-reaction chamber. It has broad application prospects in many scientific fields such as lab-on-a-chip, biological intelligence monitoring, and rapid physiological assays. [0003] At present, methods for liquid and solid manipulation in microdroplets can be divided into two categories: passive and active. [0004] The passive method is to complete the mixing of multiple components in the micro-dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273
Inventor 段学欣申晓天李铁川庞慰
Owner TIANJIN UNIV
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