Application of metal-organic ligand framework ZIF-67 modified hollow vanadium dioxide core-membrane composite structure drug carrier
A ZIF-67, organic ligand technology, applied in the field of biomaterials and regenerative medicine, can solve the problems of loss of dryness, easy aging, and low quantity, and achieve the effect of improving therapeutic effect, promoting proliferation and increasing efficiency
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Embodiment 1
[0038] Example 1 Construction of a hollow vanadium dioxide core-membrane composite structure drug carrier modified by the metal-organic ligand framework ZIF-67
[0039] Will 1.82g V 2 o 5 Dissolve in 450mL1.6mol / L oxalic acid solution, and stir the mixed solution at room temperature until the solution becomes a khaki suspension. The obtained suspension was placed in a polytetrafluoroethylene reactor for hydrothermal reaction, and kept at 180° C. for 36 hours. Naturally cool to normal temperature after the reaction and collect the blue-black precipitate VO 2 Dry in a constant temperature ventilated drying oven at 60°C.
[0040] Take out 100mg of the prepared VO 2 Disperse evenly in 200mL of methanol solution, add 3g of cobalt nitrate hexahydrate, stir evenly, add 300mL of 0.2g / mL 2-methylimidazole in methanol solution, stir at room temperature for more than 24 hours, make it fully react, and prepare the sample Centrifugal washing with deionized water and ethanol, and vacuu...
Embodiment 2
[0042] Example 2 Construction of a hollow vanadium dioxide core-membrane composite structure drug carrier modified by the metal-organic ligand framework ZIF-67
[0043] Will 1.82g V 2 o 5 Dissolve in 500mL1.2mol / L oxalic acid solution, and stir the mixed solution at room temperature until the solution becomes a khaki suspension. The obtained suspension was placed in a polytetrafluoroethylene reactor for hydrothermal reaction, and kept at 300° C. for 28 hours. Naturally cool to normal temperature after the reaction and collect the blue-black precipitate VO 2 Dry in a constant temperature ventilated drying oven at 60°C.
[0044] Take out 100mg of the prepared VO 2 Disperse evenly in 300mL of methanol solution, add 5g of cobalt nitrate hexahydrate, stir evenly, add 500mL of 0.15g / mL 2-methylimidazole in methanol solution, stir at room temperature for more than 24 hours, make it fully react, and prepare the sample Centrifugal washing with deionized water and ethanol, and vacu...
Embodiment 3
[0045] Example 3 VO 2 Determination of specific surface area and pore diameter of @ZIF-67 core-membrane composite drug carrier
[0046] Take out the VO that embodiment 1,2 makes 2 , placed in an oven at 60°C for 1 to 2 hours, then cooled to room temperature, cleaned and dried the empty sample tube, and degassed the empty sample tube at 120°C for 1 hour. Add the dried sample into the empty sample tube, then degas the sample under vacuum at 150°C for 2 hours, then cool to room temperature. Transfer the degassed sample to the analysis station for low-temperature nitrogen adsorption, use a Dewar bottle filled with liquid nitrogen to test the sample at a constant temperature, and then use the sample as the adsorbent, high-purity nitrogen as the adsorbate and high-purity helium as the The carrier is subjected to isothermal adsorption and desorption at the temperature of 77.3K liquid nitrogen and the relative pressure point of nitrogen in the range of 0.048 to 0.996. The nitrogen a...
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