Preparation method of compound polyethylene glycol electrolyte particles

A polyethylene glycol and electrolyte technology, applied in the field of medicine, can solve problems such as uncontrollable quality of compound polyethylene glycol electrolyte preparations, packaging and adsorption of electrolyte inorganic salts, and difficulty in mixing uniformly, so as to achieve controllable product quality and reduce component variation , The effect of simple production process

Pending Publication Date: 2022-03-22
HANGZHOU XINBOSI BIOMEDICAL CO LTD
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  • Abstract
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Problems solved by technology

[0003] In order to solve the above problems, the present invention provides a preparation method of compound polyethylene glycol electrolyte particles to solve the problem of uncontrollable quality, difficulty in mixing, secondary layering, electrolyte inorganic salts and other problems in the preparation process of compound polyethylene glycol electrolyte preparations. Problems such as packaging adsorption and cumbersome use

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  • Preparation method of compound polyethylene glycol electrolyte particles
  • Preparation method of compound polyethylene glycol electrolyte particles
  • Preparation method of compound polyethylene glycol electrolyte particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Spray drying to prepare compound polyethylene glycol electrolyte particles:

[0048] Compound polyethylene glycol electrolyte granule formulation (prepared with 6.9kg of total material per batch) is shown in Table 1:

[0049] Table 1 Formula of compound polyethylene glycol electrolyte particles

[0050]

[0051] Preparation method: Weigh each component of the prescription amount in Table 1, crush 1.29 parts of sodium bicarbonate, 2.53 parts of sodium chloride, and 0.33 parts of potassium chloride and sieve it, and control the particle size to pass through the No. 7 sieve 30%~100%, then mix evenly with 40 parts of polyethylene glycol 3350, heat and melt the material at 65°C, stir and mix, then spray dry, adjust the spray drying air volume to 60%, and the air inlet temperature to 30°C , the atomization pressure was 1.5 bar, and the feed rate was 100%, to obtain polyethylene glycol particles wrapped with electrolyte inorganic salts. Mix the prepared polyethy...

Embodiment 2

[0058] Example 2 Preparation of compound polyethylene glycol electrolyte particles by spray drying:

[0059] Preparation method: Weigh each component of the prescription amount in Table 1, crush 1.29 parts of sodium bicarbonate, 2.53 parts of sodium chloride, and 0.33 parts of potassium chloride and sieve it, and control the particle size to pass through the No. 7 sieve 30%~100%, mix evenly with 95 parts of polyethylene glycol 3350, heat and melt the material at 70°C, stir and mix, then spray dry, adjust the spray drying air volume to 100%, and the air temperature to -20°C , the atomization pressure was 5 bar, and the feed rate was 100%, to obtain polyethylene glycol particles wrapped with electrolyte inorganic salts. Mix the prepared polyethylene glycol granules wrapped with electrolyte inorganic salts with sweetener and flavor evenly to obtain compound polyethylene glycol electrolyte granules (prescription 2). Perform Na on prescription 2 + 、K + Content detection, measure...

Embodiment 1

[0066] Comparative Example 1 Direct Mixing Process Prepares Compound Polyethylene Glycol Electrolyte Particles

[0067] Prepare compound polyethylene glycol electrolyte particles by direct mixing process: weigh 95 parts by weight of polyethylene glycol 3350, 1.29 parts of sodium bicarbonate, 2.53 parts of sodium chloride, and 0.33 parts of potassium chloride. Potassium chloride and sodium bicarbonate particle size is No. 7 sieve pass rate 30%~100%, take 1 part of polyethylene glycol 3350 and 1.29 parts of sodium bicarbonate, 2.53 parts of sodium chloride, 0.33 parts of potassium chloride, and mix for 10 minutes Add 46.5 parts of polyethylene glycol 3350 and mix for 10 minutes; finally add 47.5 parts of polyethylene glycol 3350, 0.07 parts of sweetener and 0.72 parts of essence, and mix for 30 minutes to obtain compound polyethylene glycol electrolyte particles (prescription 3). Perform Na on prescription 3 + 、K + Content detection, measure twice, content detection result is ...

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Abstract

The invention discloses a preparation method of compound polyethylene glycol electrolyte particles. The compound polyethylene glycol electrolyte granules are prepared by adopting a spray drying process. The preparation technology is simple, industrialization is easy to achieve, the quality of the compound polyethylene glycol electrolyte particles prepared through the technology is controllable, and the problems of mixing uniformity, secondary layering and packaging adsorption in the production and preparation process of the polyethylene glycol electrolyte particles are solved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of compound polyethylene glycol electrolyte granules. Background technique [0002] Compound polyethylene glycol electrolyte granule is the most widely used intestinal cleansing preparation at home and abroad. The drug is a compound preparation, and its main ingredients are polyethylene glycol, sodium chloride, potassium chloride, and sodium bicarbonate. Compound polyethylene glycol electrolyte granules are often prepared by direct mixing process, but because polyethylene glycol and electrolyte inorganic salts have different particle bulk density, particle size, particle shape, porosity, fluidity, etc., the ratio of each component The difference is huge. During the product preparation process, polyethylene glycol and electrolyte are difficult to mix evenly, and the phenomenon of secondary layering is easy to occur, and the mixing uniformity is no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/50A61P1/00A61K31/77A61K33/00
CPCA61K31/77A61K33/00A61K33/14A61K9/5031A61P1/00A61K2300/00
Inventor 陆亚萍蔡盛刘艳华叶睿玲金惠红胡倩
Owner HANGZHOU XINBOSI BIOMEDICAL CO LTD
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