Nanoparticle colloid cluster and structure-controllable preparation method based on emulsion method

A nanoparticle and inorganic nanoparticle technology, applied in the field of nanoparticle colloidal cluster materials, can solve the problems of inaccurate control of the spatial configuration of colloidal clusters, high cost of DNA molecules, cumbersome nanoparticle modification process, etc. production effect

Active Publication Date: 2022-03-29
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0004] The invention solves the technical problems of cumbersome nanoparticle modification process, high cost of DNA molecules, and unaccurate control of the spatial configuration of colloidal clusters in the prior art, and provides a controllable preparation of nanoparticles based on uniform modification of oil-soluble polymers. The method of colloidal clusters uses nanoparticles uniformly modified by oil-soluble polymers as assembly units, and introduces them into oil-in-water emulsion droplets with uniform diameters. particle colloidal cluster

Method used

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  • Nanoparticle colloid cluster and structure-controllable preparation method based on emulsion method
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  • Nanoparticle colloid cluster and structure-controllable preparation method based on emulsion method

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preparation example Construction

[0039] (1) Preparation of oil phase: Synthesize inorganic nanoparticles with uniform size by hydrothermal method or oil thermal method; use functional group-terminated oil-soluble polymers to uniformly modify the surface of inorganic nanoparticles by ligand exchange method; Take the precipitate after centrifugation, and then disperse it in a water-immiscible oil phase organic solvent to obtain an oil phase in which the polymer uniformly modifies inorganic nanoparticles; the rotational speed of the centrifugal precipitation is 5,000-18,000rpm; the centrifugal The precipitation time is 0.2-1h; the concentration of the nanoparticle oil phase is 0.001-1mg / mL;

[0040] (2) Preparation of emulsion droplets: the oil phase obtained in step (1) is mixed with the water phase containing surfactant, the mixed solution is added to the membrane emulsification device, and the diameter is obtained by manually extruding back and forth 20-100 times. Uniform oil-in-water emulsion droplets; the mix...

Embodiment 1

[0052] A method for preparing a structure-controllable colloidal nanoparticle cluster based on an emulsion method, specifically comprising the following steps:

[0053] (1) Preparation of the oil phase: using mercapto-terminated polystyrene with a molecular weight of 12 kDa, the surface of gold nanoparticles with a diameter of 32 nm was uniformly modified by a ligand exchange method. After centrifugation at 10,000rpm for 0.5h, the precipitate was collected, and then dispersed in the in toluene.

[0054] The gold nanoparticles are prepared according to the following method: a sodium citrate aqueous solution with a concentration of 30 mg / mL and an aqueous chloroauric acid solution with a concentration of 10 mg / mL are prepared, and 1 mL of the above-mentioned chloroauric acid solution is added to 100 mL of ultrapure water, heated to boiling , followed by adding 1 mL of the above sodium citrate solution and reacting at 100° C. for 30 minutes. Then the temperature was lowered to ...

Embodiment 2

[0059] A method for preparing a structure-controllable colloidal nanoparticle cluster based on an emulsion method, specifically comprising the following steps:

[0060] (1) Preparation of the oil phase: using mercapto-terminated polystyrene with a molecular weight of 5 kDa, the surface of gold nanoparticles with a diameter of 32 nm was uniformly modified by a ligand exchange method. After centrifugation at 10,000rpm for 0.5h, the precipitate was collected, and then dispersed in the in toluene.

[0061] (2) Preparation of emulsion droplets: cetyltrimethylammonium bromide was dissolved in water at a concentration of 1 mg / mL, and 100 μL of the above oil phase with different concentrations were mixed with 1 mL of the above water phase. Add the mixed solution to the membrane emulsification device ( figure 1 ), the pore size of the filter membrane of the emulsification device was 0.5 μm, and the oil-in-water emulsion droplets with a diameter of 2 μm and uniform diameter were obtai...

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Abstract

The invention relates to a nanoparticle colloid cluster and a structure-controllable preparation method based on an emulsion method, and belongs to the technical field of nanoparticle colloid cluster materials. The invention discloses a method for preparing a structure-controllable nanoparticle colloid cluster based on an emulsion method. The preparation method comprises the following steps: firstly, uniformly grafting a polymer on the surfaces of the nanoparticles, and dispersing the nanoparticles in a water-insoluble oil-phase organic solvent; mixing a water phase containing a surfactant, and obtaining emulsion liquid drops with uniform diameters through a membrane emulsification method; and finally, volatilizing the organic solvent in the emulsion liquid drops to obtain the required nano particle colloid cluster. According to the preparation method, non-uniform modification required for preparing the nano particle colloid cluster is avoided, and the obtained nano particle colloid cluster comprises an inorganic nano particle dispersed phase and a polymer continuous phase; the inorganic nanoparticles in the dispersed phase have specific number, variety and proportion, and the spatial arrangement of the inorganic nanoparticles presents a specific geometrical shape.

Description

technical field [0001] The invention belongs to the technical field of nanoparticle colloidal cluster materials, and more specifically relates to a nanoparticle colloidal cluster and a structure-controllable preparation method based on an emulsion method. Background technique [0002] Nanoparticle colloidal clusters refer to a class of particle clusters with a specific spatial configuration formed by a certain number or type of inorganic nanoparticles through directional assembly. Due to the coupling synergy between different nanoparticles, nanoparticle colloidal clusters exhibit excellent properties that individual particles do not possess. In addition, the properties of nanoparticle colloidal clusters can be flexibly tuned by changing the properties of the nanoparticles as well as the structure of the colloidal cluster itself. Therefore, nanoparticle colloidal clusters are widely used in many fields, such as biomedicine, optoelectronic devices, storage materials, in vivo ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00
CPCB01J13/00
Inventor 朱锦涛吴明许江平
Owner HUAZHONG UNIV OF SCI & TECH
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