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Composition and medicine for treating cardiovascular and cerebrovascular diseases as well as preparation method and application of composition and medicine

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the field of compositions for the treatment of cardiovascular and cerebrovascular diseases. quick results

Inactive Publication Date: 2022-04-12
青海晶珠藏药高新技术产业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, in the original preparation process, no matter whether it is water decoction or ethanol extraction, the dissolution of the active ingredients has not reached the ideal level, which limits the efficacy of the drug. Therefore, it is necessary to optimize the process conditions of water decoction and ethanol extraction. , to increase the dissolution rate of active ingredients

Method used

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  • Composition and medicine for treating cardiovascular and cerebrovascular diseases as well as preparation method and application of composition and medicine
  • Composition and medicine for treating cardiovascular and cerebrovascular diseases as well as preparation method and application of composition and medicine
  • Composition and medicine for treating cardiovascular and cerebrovascular diseases as well as preparation method and application of composition and medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, investigate the impact of different water extraction process conditions on active ingredients

[0034] The composition of the prescription is as follows:

[0035] Saffron whole flower 70g, rhodiola rosea 200g, sumac 150g, angelica 200g, dannanxing 50g, chuanxiong 200g, astragalus 300g, earthworm 150g, achyranthes bidentata 150g.

[0036] The preparation method is as follows:

[0037] 1) Decoct the prescribed amount of Astragalus membranaceus, Earthworm, Sappan, and Achyranthes bidentata with water for three times, combine the three extracts, filter, concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), and dry at 90°C , pulverized to obtain medicinal powder 1;

[0038] 2) Rhizoma Chuanxiong, Angelica, Rhodiola (consumption is 6 times of the volume of Rhizoma Chuanxiong, Angelica, Rhodiola) of the prescribed amount were soaked for 60 minutes, then extracted three times with a volume fraction of 70% ethanol aqueous solution (adding 6 fo...

Embodiment 2

[0048] Embodiment 2, investigate the impact of different alcohol extraction process conditions on active ingredients

[0049] The composition of the prescription is the same as in Example 1.

[0050] The preparation method is as follows:

[0051] 1) Decoct the prescription amount of Astragalus membranaceus, Earthworm, Sappan, and Achyranthes bidentata with water three times (add 10 times the volume of water, soak for 120 minutes, and add water for three decoctions in order of the above-mentioned Astragalus, Earthworm, and Suxie). 10 times, 7 times, and 4 times the volume of Achyranthes chinensis and Achyranthes chinensis; the time of decocting three times was 4 hours, 2 hours, and 1 hour in turn.), the three extractions were combined, filtered, and concentrated to a relative density of 1.30 to 1.35 ( 50°C) thick paste, dried at 90°C and pulverized to obtain medicinal powder 1;

[0052] 2) Extract the prescription amount of Rhizoma Chuanxiong, Angelica, and Rhodiola three tim...

Embodiment 3

[0062] Embodiment 3, the drug effect comparison after the different parts of saffron are used as medicine

[0063] According to the different drug parts of saffron, the following two Jingzhu Shuanghong Huoxue capsule preparations were prepared respectively, and their protective effects on myocardial ischemia-reperfusion injury in rats were observed.

[0064] (1) Preparation A: 70g of saffron whole flower, 200g of rhodiola rosea, 150g of sumac, 200g of angelica, 50g of Dannanxing, 200g of Chuanxiong, 300g of astragalus, 150g of earthworm, 150g of Achyranthes bidentata, prepared according to the method of the above-mentioned embodiment 1 .

[0065] (2) B preparation: Saffron stigma 5g, Rhodiola rosea 200g, Sappan 150g, Angelica 200g, Dannanxing 50g, Rhizoma Chuanxiong 200g, Astragalus 300g, Dilong 150g, Achyranthes bidentata 150g, prepared according to the method of above-mentioned embodiment 1.

[0066] The results are shown in Table 5. ATP / ADP: A preparation group was signif...

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Abstract

The invention provides a medicine for treating cardiovascular and cerebrovascular diseases. The medicine is prepared from the following raw materials in parts by mass: 60 to 80 parts of saffron crocus whole flower, 50 to 250 parts of rhodiola rosea, 100 to 200 parts of sappan wood, 100 to 300 parts of angelica sinensis, 50 to 150 parts of arisaema cum bile, 150 to 250 parts of ligusticum wallichii, 200 to 400 parts of astragalus membranaceus, 100 to 200 parts of earthworm and 100 to 200 parts of achyranthes bidentata. The preparation method comprises the following steps: 1) adding water into astragalus membranaceus, lumbricus, hematoxylon and achyranthes bidentata, decocting and extracting for three times, combining extracting solutions, filtering, concentrating into paste, drying and crushing; 2) extracting ligusticum wallichii, angelica sinensis and rhodiola rosea with an ethanol aqueous solution for three times, combining extracting solutions, concentrating into thick paste, drying and crushing; 3) drying arisaema cum bile, mixing the arisaema cum bile with the saffron crocus whole flower, and crushing; and uniformly mixing the medicinal powder, and filling into capsules to obtain the traditional Chinese medicine. By improving the prescription and the preparation process, the medicine effect of the crystal bead double-red blood-activating capsule is improved.

Description

[0001] This application is a divisional application with an application date of November 21, 2018, an application number of 201811390689.8, and an invention title of "a drug for treating cardiovascular and cerebrovascular diseases and its preparation method". technical field [0002] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a composition for treating cardiovascular and cerebrovascular diseases, a medicine, a preparation method and application thereof. Background technique [0003] Cardiovascular and cerebrovascular diseases are collectively referred to as diseases of the heart and cerebrovascular diseases. At present, cardiovascular and cerebrovascular diseases have become the diseases with high morbidity, high disability rate, high mortality rate, high recurrence rate, high medical expenses and many complications (often called "five highs and one high") in China. Cardiovascular and cerebrovascular diseases mainly refer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8884A61K9/48A61P9/10A61P9/12A61P7/02A61P25/00A61K35/62
CPCA61K36/8884A61P7/02A61P9/10A61P9/12A61P25/00A61K9/48A61K35/62A61K36/21A61K36/232A61K36/236A61K36/41A61K36/48A61K36/481A61K36/88A61K2236/39A61K2236/51A61K2236/331A61K2236/333A61K2300/00
Inventor 李方瑞
Owner 青海晶珠藏药高新技术产业股份有限公司
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