Multi-channel field effect transistor nano biosensor and preparation method and application thereof

A field effect transistor and biosensor technology, applied in the field of analysis and detection, can solve the problems of difficult to reflect the complexity of tumors, false negatives, easy to appear false positives, etc., to achieve excellent electrical performance, simplify detection steps, and improve detection throughput. Effect

Pending Publication Date: 2022-04-15
WUHAN UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considering the differences between individuals and the heterogeneity of solid tumors, it is difficult to reflect the complexity of the tumor by using only a single marker as the detection standard, and it is prone to false positive or false negative results

Method used

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  • Multi-channel field effect transistor nano biosensor and preparation method and application thereof
  • Multi-channel field effect transistor nano biosensor and preparation method and application thereof
  • Multi-channel field effect transistor nano biosensor and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Construction of a multi-channel IGZO FET sensor:

[0047] S1 preparation of gold electrodes:

[0048] S1.1 Use CAD software to design an electrode pattern consisting of 5 sources, 1 drain, and 1 gate, and process it into a corresponding mask for subsequent photolithography operations.

[0049] S1.2 Select a p-type silicon wafer with a 300nm silicon oxide layer as the substrate, uniformly spin-coat a layer of positive photoresist AZ521 on its surface, and then place the silicon wafer with the spin-coated photoresist on a heating plate at 115°C Heat for 4 minutes to solidify the photoresist. Then, the pattern on the mask plate is exposed with the help of an ultraviolet lithography machine, and the electrode pattern is transferred to the spin-coated photoresist, and developed with ZX-238 developer to expose the position of the electrode.

[0050] S1.3 A 15nm Cr layer and a 50nm Au layer are uniformly deposited on the surface of the silicon wafer in S1 using a thermal eva...

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Abstract

The invention discloses a multichannel field effect transistor nano biosensor and a preparation method and application thereof, and belongs to the field of analysis and detection. According to the multi-channel field effect transistor nano biosensor, the corresponding relation between the bladder cancer marker concentration and an indium gallium zinc oxide (IGZO) field effect transistor sensing device electric signal is established, so that a plurality of bladder cancer markers in a urine sample can be rapidly detected at the same time. The field effect transistor nano biosensor can realize simultaneous rapid detection of a plurality of cancer markers in a urine sample, and well makes up for the defects in the current bladder cancer diagnosis field. The sensor has the advantages of high detection flux, high sensitivity, good selectivity, high detection speed, good reproducibility and the like, and has a wide clinical application prospect in the field of tumor marker detection.

Description

technical field [0001] The invention relates to the field of analysis and detection, in particular to a multi-channel field-effect transistor nano-biosensor and its preparation method and application. [0002] technical background [0003] Bladder cancer is one of the most common malignant tumors of the urinary system, which is characterized by strong invasiveness and high recurrence rate. About 75% of new bladder cancer patients are non-muscle-invasive bladder cancer, and 25% progress to the muscle-invasive stage. Early diagnosis is of great significance to prevent patients from developing muscle-invasive bladder cancer and improve the survival rate of patients. Although non-muscle invasive bladder cancer is not life-threatening, the five-year recurrence rate after local treatment is as high as 50% to 70%. In order to prevent the deterioration of the condition, patients need to be regularly reviewed at any time and insist on long-term follow-up. At present, the methods us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/414G01N33/574G01N33/573G01N33/543G01N33/531
Inventor 袁荃杨雁冰王懿鸣
Owner WUHAN UNIV
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