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Microparticles comprising cellulose nanocrystals aggregated with proteins and cosmetic use thereof

A technology of nanocrystals and protein aggregation, applied in cosmetics, cosmetic preparations, medical preparations containing active ingredients, etc., can solve problems such as high degradation rate and poor mechanical properties

Pending Publication Date: 2022-04-15
ANOMERA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even when blended with other polymers in an attempt to improve stability, microbeads made from these proteins still have the negative characteristics of poor mechanical properties and high degradation rates

Method used

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  • Microparticles comprising cellulose nanocrystals aggregated with proteins and cosmetic use thereof
  • Microparticles comprising cellulose nanocrystals aggregated with proteins and cosmetic use thereof
  • Microparticles comprising cellulose nanocrystals aggregated with proteins and cosmetic use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

[0266] Example 1-7 - Fibroin / cellulose microparticles

[0267] Preparation of Fibroin Solution #1

[0268] Add 1-2g silk fibroin (from Ikeda Corporation - cosmetic grade silk fibroin powder) to 5.55g CaCl at 80°C 2 , 4.6g ethanol, 7.2g distilled water (CaCl 2 : ethanol : H 2 The molar ratio of O is 1:2:8). (Caution: Ajisawa solvent mixture generates a lot of heat). Press down the silk fibroin so that it is completely immersed in the solvent. After 20-30 minutes, the fibroin appears to be completely dissolved and the solution becomes clear and yellow in color.

[0269] The fibroin solution was pipetted into cellulose dialysis tubing and dialyzed against distilled water in a 3.5 L glass beaker. Change the water every hour for the first day, then every half day thereafter. The entire dialysis process took three days.

[0270] After dialysis, the fibroin concentration of the solution in the dialysis tubing is 1.5-2.0% by weight.

[0271] Use fibroin obtained from other so...

Embodiment 1

[0304] Example 1 - Hydrophobic fibroin / cellulose microparticles derived from carboxylated CNC and silk fibroin

[0305] CNC suspension #1 (2.17 wt% CNC) was mixed with fibroin solution #1 (1.8 wt%) such that the final fibroin content was 2 wt% compared to the CNC content. The mixing of CNC and fibroin solution is carried out under minimum shear force, which ensures efficient agitation of volume size. Stirring was carried out until the solution reached homogeneity within 10 minutes. The suspension was spray dried immediately (Techni Process spray dryer, model SD-1; inlet temperature 190°C, outlet temperature 89-92°C, nozzle pressure 2 bar, pressure difference 180 mm WC). After spray drying, the resulting free-flowing white powder can be washed with alcohols such as ethanol, and then placed in an oven at 80°C for 30 minutes to improve the hydrophobic effect. In the obtained microparticles, the content of silk fibroin was 2% by weight.

[0306] Figure 2A) shows a powder sample...

Embodiment 2

[0308] Example 2 - Hydrophobic fibroin / cellulose microparticles wherein the silk fibroin content ranges from 0.5% to 50% by weight compared to the carboxylated CNC content.

[0309] Hydrophobic microparticles were obtained in the same manner as described in Example 1.

[0310] More specifically, silk fibroin solution (2wt%) was added to CNC suspension #1 (0.5wt%) under vigorous stirring to obtain 5wt%, 10wt%, 20wt% and 50wt% of SF solution. The resulting suspension was spray dried on a Büchi MiniSpray Dryer Type B-191 (inlet temperature 175°C and outlet temperature 100°C, 30% pump speed, 70% aspirator). Some samples were treated with methanol to increase the proportion of beta sheet SF in the beads.

[0311] The powder obtained is hydrophobic.

[0312] Figure 4 shows the SEM image of the microparticles obtained.

[0313] For comparison, Figure 5 shows microparticles obtained by spray drying silk fibroin only (ie without CNC).

[0314] The presence of SF in the form of β-s...

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Abstract

The invention provides protein cellulose microparticles. These microparticles comprise cellulose nanocrystals and one or more peptides, one or more proteins, or mixtures thereof, wherein the nanocrystals aggregate with the peptides and / or proteins to form microparticles. In embodiments, the microparticles comprise silk fibroin, and advantageously, the silk fibroin is hydrophobic and lipophilic. The invention also provides cosmetic products comprising these microparticles. In advantageous embodiments, these cosmetic articles comprise a water-in-oil emulsion or a lipophilic medium. Finally, the invention also provides a method for preparing the microparticles.

Description

[0001] Cross References to Related Applications [0002] Pursuant to 35 U.S.C. §119(e), this application claims priority to U.S. Provisional Application 62 / 846,281, filed May 10, 2019. technical field [0003] The present invention relates to proteinaceous cellulose microparticles. More specifically, the present invention relates to microparticles comprising protein and cellulose nanocrystals, and which are hydrophobic, have increased oil absorption and / or improved skin feel. Background technique [0004] About Microbeads [0005] Microparticles play an important role in drug delivery, cosmetics and skin care, fluorescent immunoassays, as microcarriers in biotechnology, as viscosity regulators, stationary phases in chromatography and as abrasives. In these and other fields, microparticles are often referred to as "beads." [0006] The cosmetic and personal care industries utilize microbeads to enhance the sensory properties in formulations and to protect or improve the sk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K47/38A61K47/42A61K8/02A61K8/04A61K8/06A61K8/64A61K9/14B01J13/04C07K1/00C07K14/435C07K17/12
CPCA61K8/64C07K17/12A61K8/731A61K2800/412A61K2800/413A61K8/0287A61K8/0279A61Q19/00A61K2800/10C07K14/43586A61K8/064
Inventor M·P·安德鲁斯T·莫尔斯M·拉克J·吴Z·胡M·贝特曼
Owner ANOMERA INC
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