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Two-dimensional ultrathin PdRu nanosheet as well as preparation method and application thereof

A nanosheet and ultra-thin technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as difficulty in satisfying multimodal treatment of tumors, limited performance of nanomaterials, shallow penetration depth of tissue, etc., and achieve excellent photothermal performance And catalytic performance, good biocompatibility, high activity effect

Pending Publication Date: 2022-04-19
NANJING UNIV OF POSTS & TELECOMM
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  • Claims
  • Application Information

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Problems solved by technology

As a representative two-dimensional metal nanosheet, Pd nanosheets have a good photothermal treatment effect in the first near-infrared window, but the laser in the first near-infrared region has shallow penetration depth into tissues, low imaging contrast, and phototoxicity. High defects, and the performance of single-component nanomaterials is limited, it is difficult to meet the needs of multimodal treatment of tumors

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  • Two-dimensional ultrathin PdRu nanosheet as well as preparation method and application thereof
  • Two-dimensional ultrathin PdRu nanosheet as well as preparation method and application thereof
  • Two-dimensional ultrathin PdRu nanosheet as well as preparation method and application thereof

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Embodiment 1

[0058] This embodiment provides a method for preparing two-dimensional ultrathin PdRu nanosheets, which specifically includes the following steps:

[0059] S1. Add 30mg of polyvinylpyrrolidone, 170mg of citric acid, 60mg of cetyltrimethylammonium bromide, and 16mg of palladium acetylacetonate into 10mL of N, N-dimethylformamide and mix them uniformly; transfer the homogeneous solution to Fill the 50mL flask with argon for 30min, add 100mg tungsten hexacarbonyl, heat and stir in an oil bath at 80°C for 1h, cool to room temperature, add 30mL acetone and let it stand for 30min, centrifuge at 6000rpm for 5min to obtain a black lump, continue to add 45mL of acetone and ethanol The mixed solution was ultrasonically washed twice, ultrasonically dispersed in 10mL of ethylene glycol;

[0060] S2. Add 5mL of ethylene glycol to 50mg of polyvinylpyrrolidone and 50mg of sodium ascorbate and mix them uniformly by ultrasonication. Continue to add 5mL of the product from the previous step and...

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Abstract

The invention discloses a two-dimensional ultrathin PdRu nanosheet and a preparation method and application thereof.The preparation method comprises the steps that S1, a surfactant, a nucleating agent, an end-capping reagent and palladium acetylacetonate are added into N, N-dimethylformamide and mixed to be uniform, tungsten hexacarbonyl is added, a reaction is conducted under the protection of inert gas at the temperature of 60-90 DEG C, and Pd nanosheets are obtained and then evenly dispersed in ethylene glycol; s2, uniformly mixing polyvinylpyrrolidone, a reducing agent and ethylene glycol, adding a product in the step S1, heating to 160 DEG C, adding an ethylene glycol solution in which ruthenium acetylacetonate is uniformly dissolved, continuously reacting at 160 DEG C, cooling to room temperature, adding acetone, centrifuging to obtain a black block mineral substance, performing ultrasonic washing for three times by using a mixed solution of acetone and ethanol, and drying to obtain a black block mineral substance; and dispersing the obtained product in ultrapure water. The prepared two-dimensional ultrathin PdRu nanosheet has good biocompatibility, excellent photo-thermal performance and catalytic performance, and can be applied to tumor treatment.

Description

technical field [0001] The invention relates to a two-dimensional ultra-thin PdRu nanosheet and its preparation method and application, belonging to the technical field of photothermal nanomaterials. Background technique [0002] Two-dimensional metal nanomaterials have been widely used in biological diagnosis and treatment due to their large surface area, wide absorption in the near-infrared region, good biocompatibility, and excellent enzyme-like activity. As a representative two-dimensional metal nanosheet, Pd nanosheets have a good photothermal treatment effect in the first near-infrared window, but the laser in the first near-infrared region has shallow penetration depth into tissues, low imaging contrast, and phototoxicity. High-level defects and limited performance of single-component nanomaterials are difficult to meet the needs of multimodal treatment of tumors. Contents of the invention [0003] In order to overcome the deficiencies in the prior art, the present...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/054A61K41/00A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCB22F9/24A61K41/0052A61P35/00B82Y5/00B82Y30/00B82Y40/00
Inventor 罗志敏李琦李岩黄竹胜张颖汪联辉
Owner NANJING UNIV OF POSTS & TELECOMM
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