Irradiated biological material aqueous solution as well as preparation method and use method thereof

Abstract

The invention relates to the field of biological materials, in particular to an irradiated biological material aqueous solution as well as a preparation method and a use method thereof. In order to avoid the heterogeneity or agglomeration phenomenon caused by irradiation of a biological material aqueous solution in conventional operation, the microenvironment of biological material molecules in the aqueous solution is optimized from the aspects of enhancing the ionic environment of the aqueous solution, regulating and controlling the pH value to balance the surface electrical property of the biological material molecules, adding protective molecules and the like. The aqueous solution of the biological material keeps a homogeneous flow state, and can be directly used clinically in the form of a homogeneous aqueous solution, directly contacted with skin or injected into a human body.

Description

technical field [0001] The present invention relates to an aqueous solution of irradiated biological material, its preparation method and use method. Background technique [0002] As one of the sterilization methods for aqueous solutions of biological materials, irradiation sterilization is to kill microorganisms by directly or indirectly destroying the ribonucleic acid, protein and enzymes of microorganisms to play a role in disinfection and sterilization. Although irradiation sterilization has the advantages of strong penetrating power, no residue, and convenient operation, irradiation will also destroy the molecular bonds of biomaterials, resulting in recombination, chain scission or crosslinking of biomaterial molecules, resulting in apparent Changes in the physical and chemical properties of biological material aqueous solutions may even affect their efficacy. Especially when the biological material molecules in the aqueous solution are irradiated to produce active ing...

AI Technical Summary

Problems solved by technology

Although irradiation sterilization has the advantages of strong penetrating power, no residue, and convenient operation, irradiation will also destroy the molecular bonds of biomaterials, resulting in recombination, chain scission or crosslinking of biomaterial molecules, resulting in apparent Changes in the physical and chemical properties of biological material aqueous solutions may even affect their efficacy

Especially when the biological material molecules in the aqueous solution are irradiated to produce active ingredients to cross-link, it is easy to combine with water molecules to form insoluble matter or hydrogel structure, which will significantly reduce the fluidity of the biological material aqueous solution, resulting in the biological material aqueous solution after irradiation. Cannot be used normally in fluid form

In addition, the irradiation process may be accompanied by an increase in temperature, which is likely to directly affect the biological activity of the biomaterial

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