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Refining method of aspirin-lysine

The technology of a lysine pyrin and a refining method is applied in chemical instruments and methods, the preparation of organic compounds, the preparation of carboxylate, etc., and can solve problems such as improper storage conditions and sudden abnormal production conditions, and achieve low cost and method Simple and easy to implement, the effect of simple method and process

Pending Publication Date: 2022-04-26
BENGBU BBCA MEDICINE SCI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the relatively harsh storage conditions of lysine-pirin, problems such as sudden abnormalities in production conditions or improper storage conditions will inevitably occur in the production process of the enterprise, which will lead to a high content of free salicylic acid in lysine-pirin. To reduce the content of free salicylic acid in this lysine pirin product, it is necessary to develop a method for refining lysine pirin with simple process and low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The present embodiment provides a kind of refining method of lysine pirin, and the steps are as follows:

[0027] In the 500mL there-necked bottle, add 10.0g of lysine-pirin solid (free salicylic acid content is 0.73%), add the ethanol aqueous solution 49.0g that mass percent concentration is 50%, set dissolving temperature to be 29 ± 1 ℃, stir to make lysine All of the pyrin solids dissolved.

[0028] After the dissolution was complete, 150.0 g of absolute ethanol was added, the temperature was lowered to 5° C., and the crystallization was carried out by heat preservation for 0.5 h. The crystallization was carried out under the condition of stirring, and the stirring speed was 50 rpm. After filtering, the solid was washed twice with 10.0 g of absolute ethanol, sucked dry, and then dried the solid to obtain the refined product of lysine-pirin.

Embodiment 2

[0030] The present embodiment provides a kind of refining method of lysine pirin, and the steps are as follows:

[0031] In the 500mL three-necked bottle, add 10.0g of lysine-pirin solid (free salicylic acid content is 0.73%), add 45.0g of ethanol aqueous solution with a mass percentage concentration of 40%, set the dissolution temperature to 29±1°C, and stir to make lysine All of the pyrin solids dissolved.

[0032] After complete dissolution, 150.0 g of absolute ethanol was added, the temperature was lowered to 4° C., and the crystallization was carried out at a temperature of 0.5 h. The crystallization was carried out under the condition of stirring, and the stirring speed was 50 rpm. After filtering, the solid was washed twice with 10.0 g of absolute ethanol, sucked dry, and then dried the solid to obtain the refined product of lysine-pirin.

Embodiment 3

[0034] The present embodiment provides a kind of refining method of lysine pirin, and the steps are as follows:

[0035] In the 500mL there-necked bottle, add 10.0g of lysine-pirin solid (free salicylic acid content is 0.73%), add 38.0g of ethanol aqueous solution with a mass percentage concentration of 30%, set the dissolution temperature to 29±1°C, stir to make lysine All of the pyrin solids dissolved.

[0036] After the dissolution was complete, 150.0 g of absolute ethanol was added, the temperature was lowered to 3° C., and the crystallization was carried out at a temperature of 0.5 h. The crystallization was carried out under the condition of stirring, and the stirring speed was 50 rpm. After filtering, the solid was washed twice with 10.0 g of absolute ethanol, sucked dry, and then dried the solid to obtain the refined product of lysine-pirin.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical chemicals, and particularly discloses a refining method of aspirin-lysine. The refining method comprises the following steps: dissolving aspirin-DL-lysine in an ethanol water solution, adding absolute ethyl alcohol, cooling and crystallizing to prepare a refined aspirin-DL-lysine product. Experiments show that the content of free salicylic acid is greatly reduced after the aspirin-lysine is refined, so that the problem that the content of the free salicylic acid in the aspirin-lysine is relatively high due to sudden abnormal production conditions or improper storage conditions can be effectively solved. The method disclosed by the invention is simple in process, mild in crystallization condition, easy to control and low in cost, and has relatively high industrial application value.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a method for refining lysine. Background technique [0002] Aspirin / lysine is a double salt of aspirin and lysine. It is a non-steroidal anti-inflammatory drug and can be decomposed into lysine and aspirin in the body. Aspirin has antipyretic, analgesic, anti-inflammatory, anti-platelet aggregation and other effects. Compared with aspirin, lysinepirin is easy to dissolve and less irritating to the gastrointestinal tract. It is mainly used to treat fever and pain, such as fever caused by upper respiratory tract infection, as well as postoperative pain, joint pain, and visceral colic. [0003] Clinically, one of the adverse reactions of lysinepirin is salicylic acid reaction, manifested as headache, dizziness, tinnitus, audiovisual loss, nausea, vomiting, diarrhea, severe cases have mental disorders, rapid breathing, acid-base balance disorders a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/42C07C229/26C07C67/52C07C69/157
CPCC07C227/42C07C67/52C07C229/26C07C69/157
Inventor 陈昀张瑾林文龙徐新徐正秀
Owner BENGBU BBCA MEDICINE SCI DEV
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