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Medicine for wound repair and preparation method thereof

A wound repair and drug technology, applied in the field of pharmaceutical preparations, can solve problems such as poor treatment effect, inability to achieve treatment effect, and single pelvic floor muscle function, so as to enhance the body's antioxidant effect, speed up wound repair, and promote damaged muscle tissue. repaired effect

Inactive Publication Date: 2022-04-29
陈韶慧
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional methods include pelvic floor muscle exercise, acupuncture, electrophysiological stimulation, etc., but none of them can achieve a good therapeutic effect
However, surgery is generally performed on women with severe symptoms or older women. Surgery only solves the symptoms of pelvic floor muscles in terms of anatomy, and cannot solve a series of problems caused by pelvic floor muscle trauma from a microscopic perspective and pathophysiology.
[0004] However, the existing drugs have a single therapeutic function for the pelvic floor muscle, and the therapeutic effect is not good.

Method used

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  • Medicine for wound repair and preparation method thereof
  • Medicine for wound repair and preparation method thereof
  • Medicine for wound repair and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] A preparation method for a medicine for wound repair, comprising the following steps:

[0038] Grinding the raw materials except ginsenoside Rb1, using supercritical extraction, the extraction solvent is carbon dioxide, butane and ether, and the volume ratio is 2:1: (0.2-0.6), to obtain the extract, and the extract is passed through the chromatographic column Separate to obtain the extract, mix the extract with ginsenoside Rb1, heat and stir, and make tablets.

[0039] The combination of supercritical extraction and chromatographic column separation can increase the content and purity of the active ingredients of the medicinal materials. After the active ingredients of the medicinal materials are mixed with ginsenoside Rb1, the ability of the drug to repair the pelvic floor muscles can be enhanced, thereby improving the efficacy of the drug. The extraction solvent is carbon dioxide, butane and ether, and the volume ratio is 2:1:(0.2-0.6). In this way, the active ingred...

Embodiment 1

[0047] A medicine for wound repair, comprising the following components: 0.2g ginsenoside Rb1, 4g Chuanxiong, 15g angelica, 10g gorgon, 1g Cimicifuga, 20g yam and 5g Atractylodes macrocephala.

[0048] A preparation method for a medicine for wound repair, comprising the following steps:

[0049] Grind the raw materials except ginsenoside Rb1, use supercritical extraction, extract at 80°C for 30min, the extraction solvent is carbon dioxide, butane and ether, and the volume ratio is 2:1:0.2, to obtain the extract, and the extract is separated by layer Column separation, using a mixture of ethanol and acetone as the eluent, and the volume ratio of ethanol and acetone is 1:0.05, to obtain the extract, mix the extract with ginsenoside Rb1, stir at 60°C for 10min, and the stirring speed is 120rpm , made into tablets.

Embodiment 2

[0051] A medicine for wound repair, comprising the following components: 0.8g ginsenoside Rb1, 12g Chuanxiong, 25g angelica, 15g gorgon, 5g cohosh, 30g yam and 18g Atractylodes macrocephala.

[0052] A preparation method for a medicine for wound repair, comprising the following steps:

[0053] Grind the raw materials except ginsenoside Rb1, use supercritical extraction, extract at 90°C for 40min, the extraction solvent is carbon dioxide, butane and ether, and the volume ratio is 2:1:0.6 to obtain the extract, and the extract is separated by layer Column separation, using a mixture of ethanol and acetone as the eluent, and the volume ratio of ethanol and acetone is 1:0.2, to obtain the extract, mix the extract with ginsenoside Rb1, stir at 70°C for 20min, and the stirring speed is 150rpm , made into tablets.

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Abstract

The invention provides a medicine for wound repair and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The medicine is prepared from the following components in parts by weight: 0.2 to 0.8 part of ginsenoside Rb1, 4 to 12 parts of rhizoma chuanxiong, 15 to 25 parts of radix angelicae sinensis, 10 to 15 parts of semen euryales, 1 to 5 parts of rhizoma cimicifugae, 20 to 30 parts of rhizoma dioscoreae and 5 to 18 parts of rhizoma atractylodis macrocephalae. The medicine provided by the invention can restore the integrity and function of pelvic floor tissues from the structure by repairing the early pelvic floor tissue trauma after delivery and restoring the functions of pelvic floor muscles, fibrous connective tissues and the like, can prevent postpartum stress urinary incontinence and pelvic floor dysfunction diseases, and is good in curative effect and small in side effect. According to the preparation method, supercritical extraction and chromatographic column separation are combined for use, then the content of effective components of the medicinal materials is increased, the purity is improved, after the effective components of the medicinal materials and ginsenoside Rb1 are mixed, the repairing capacity of the medicine on pelvic floor muscles can be enhanced, and then the medicine effect is improved.

Description

technical field [0001] The present application relates to the technical field of pharmaceutical preparations, in particular, to a medicine for wound repair and a preparation method thereof. Background technique [0002] The pelvic floor muscles are the muscles at the bottom of the female pelvis. Women's pelvic floor is composed of muscles, ligaments, nerves and connective tissue, among which connective tissue is most vulnerable to damage. The process of pregnancy and childbirth in women will inevitably cause damage to the pelvic floor muscles. The pelvic floor is composed of connective tissue such as ligaments and fascia, which tightly hangs the urethra, vagina, bladder, uterus, and rectum. It has functions such as controlling urination and defecation, and supporting pelvic organs. [0003] For the treatment of pelvic floor muscle trauma, early treatment may help promote tissue healing before irreversible damage and fibrosis. Traditional methods include pelvic floor muscle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61P15/00A61P13/12A61K31/704
CPCA61K31/704A61K36/236A61K36/232A61K36/62A61K36/71A61K36/8945A61K36/284A61K9/20A61P15/00A61P13/12A61K2236/37A61K2300/00
Inventor 陈韶慧
Owner 陈韶慧
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