Polyurethane with biological stability and mechanical stability as well as preparation method and application thereof

A biological stability, polyurethane technology, applied in the field of medical polyurethane materials, can solve the problem of inability to take into account biological stability and mechanical stability at the same time, biological stability and mechanical stability cannot be taken into account at the same time, oxidation resistance stability and hydrolysis resistance stability Insufficient and other problems, to solve the problem of biological stability and mechanical stability can not be taken into account at the same time, improve biological stability, good effect of hydrolysis resistance stability

Active Publication Date: 2022-05-10
眉山尤博瑞新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0049] The present invention aims at the problem that biological stability and mechanical stability cannot be taken into account simultaneously in the existing polyurethane silicon modification research, and provides a polyurethane with biological stability and mechanical stability and its preparation method and application, and includes Related medical materials of this polyurethane
The technical purpose of the present invention is: one is to solve the problem of insufficient oxidation resistance stability and hydrolysis resistance stability existing in the existing modified polyurethane; the other is to solve the poor mechanical stability of polyurethane existing in the existing modification method The decline is relatively large, and the problems of biological stability and mechanical stability cannot be taken into account at the same time; the third is to solve the low initial mechanical strength of the existing silicon-modified polyurethane, especially the obvious change in the initial mechanical strength of polyurethane caused by the increase of silicon content. bad question

Method used

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  • Polyurethane with biological stability and mechanical stability as well as preparation method and application thereof
  • Polyurethane with biological stability and mechanical stability as well as preparation method and application thereof
  • Polyurethane with biological stability and mechanical stability as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] A polyurethane (referred to as SSPEU1) with biological stability and mechanical stability, its structural formula is as follows (n=1~80, m=1~80):

[0126]

[0127] Its preparation method is as follows:

[0128] (1) Synthesis of side chain main chain silicon-containing polyether polyurethane prepolymer: Weigh 156.1g of PTMG (Mn=1000) and 34.7g of hydroxyhydrocarbyl-terminated polydimethylsiloxane (Mn=2000) and add three Neck flask, heated to 100-105°C and dehydrated under vacuum condition for 2 hours, after cooling to 50-60°C, remove the vacuum device, blow in N 2 , add 6.6g SDO (Mn=397) and add 88.5g molten completely transparent liquid MDI and 0.05% organic bismuth catalyst, control reaction temperature under stirring and be 60 ℃ of prepolymerization reaction 45 minutes, until NCO content reaches design theoretical value, namely have to;

[0129] Wherein, the structural formula of SDO (Mn=397) is as follows:

[0130]

[0131] (2) Post-chain extension reaction:...

Embodiment 2

[0134] A polyurethane (referred to as SSPEU2) with biological stability and mechanical stability, its structural formula is as follows (n=1~80, m=1~80):

[0135]

[0136] Its preparation method is as follows:

[0137] (1) Synthesis of side chain main chain silicon-containing polyether polyurethane prepolymer: Weigh 172.6g PHMO (Mn=1000) and 38.4g hydroxyethoxy-terminated polydimethylsiloxane (Mn=2000) Add it to a three-necked flask, heat it to 100-105°C and dehydrate it under vacuum for 2h. After cooling to 40-50°C, remove the vacuum device and blow in N 2 , add 7.6g SDO (Mn=559), 65g HDI and 0.02% stannous octoate catalyst, stir to control the reaction temperature to 60°C, and prepolymerize for 45 minutes until the NCO content reaches the designed theoretical value, to get final product;

[0138] Wherein, the structural formula of SDO (Mn=559) is as follows:

[0139]

[0140] (2) Post-chain extension reaction: Cool the prepolymer prepared in the first step to 45-50°C...

Embodiment 3

[0143] A kind of polyurethane (referred to as SSPEU3) with biological stability and mechanical stability, its structural formula is as follows (n=1~80, m=1~80):

[0144]

[0145] Its preparation method is as follows:

[0146] (1) Synthesis of side chain main chain silicon-containing polycarbonate polyurethane prepolymer: Weigh 131.2g PTMG (Mn=1000) and 65.6g hydroxyethoxy-terminated polydimethylsiloxane (Mn=2000 ) into a three-necked flask, heated to 100-105°C and dehydrated under vacuum for 2 hours. After cooling to 60-70°C, remove the vacuum device and blow in N 2 , add 6.3g SDO (Mn=397) and 83.7g molten completely transparent liquid MDI and 0.1% dibutyltin dilaurate catalyst, stir and control the reaction temperature to be 80 ℃ pre-polymerization for 60 minutes, until the NCO content reaches the design theoretical value, namely have to;

[0147] Wherein, the structural formula of SDO (Mn=397) is as follows:

[0148]

[0149] (2) Post-chain extension reaction: Cool...

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Abstract

The invention provides polyurethane with biological stability and mechanical stability, a preparation method and application thereof, and a related medical implant material containing the polyurethane. The polyurethane with biological stability and mechanical stability is prepared by the following steps: (1) carrying out vacuum dehydration reaction on polyether glycol and polydimethylsiloxane glycol under a heating condition, cooling, adding diisocyanate and siloxane modified polyol at normal pressure, and carrying out prepolymerization reaction; and (2) adding a chain extender, uniformly stirring and mixing, carrying out a curing reaction at high temperature, and carrying out melt processing molding on a cured product to obtain the product. The polyurethane provided by the invention has the advantages of good biological stability, good hydrolysis resistance and oxidation resistance, good mechanical stability, high initial mechanical strength, small reduction amplitude of mechanical properties in a long-term use process, and basically no loss, and can be well used as a long-term implant material. The structural formula of the siloxane modified polyol is shown in the specification.

Description

technical field [0001] The invention belongs to the technical field of medical polyurethane materials, and specifically relates to a biologically stable and mechanically stable polyurethane, its preparation method and application, as well as related medical materials prepared from the polyurethane, especially long-term medical implant materials. Background technique [0002] Polyurethane (PU) came out in 1937 and was prepared by the famous German chemist Dr. Otto Bayer by reacting isocyanate and polyol. Polyurethane was first developed and used in a large number of industrial fields, but its application in the biomedical field did not begin to be extensively studied until the 1960s. According to literature [1] It was reported that in 1967, Boretos et al suggested that polyurethane should be used as a biological material in tissue engineering for the first time, and then a series of polyurethanes were synthesized and quickly applied in the medical field. Among all implantab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/61C08G18/48C08G18/12C08G18/32C08G18/38C08J5/18A61L31/14A61L31/06
CPCC08G18/6674C08G18/61C08G18/4854C08G18/4858C08G18/12C08J5/18A61L31/06A61L31/14C08G18/3206C08G18/3893C08L75/04
Inventor 谭鸿李震李洁华吴和成张涛唐林何学令傅强
Owner 眉山尤博瑞新材料有限公司
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