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Carbon dot with rosmarinic acid as carbon source and preparation method and application thereof

A technology of rosmarinic acid and carbon dots, which is applied in the field of nanomaterials, can solve the problems of application limitation, high biological toxicity, and is not easily soluble in water, and achieves the effects of simple preparation method, uniform particle size and good water solubility.

Active Publication Date: 2022-05-13
苏州深得源健康科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, the fluorescent probes used in the existing fluorescence methods are mostly semiconductor quantum dots and organic dyes. Semiconductor quantum dots and organic dyes have the characteristics of high biological toxicity and poor solubility in water, which limits their application in the human body.

Method used

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  • Carbon dot with rosmarinic acid as carbon source and preparation method and application thereof
  • Carbon dot with rosmarinic acid as carbon source and preparation method and application thereof
  • Carbon dot with rosmarinic acid as carbon source and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0055] Embodiment 1: A kind of carbon dot

[0056] This embodiment provides a kind of carbon dots (CDs), the carbon dots are nitrogen-doped carbon dots, and the carbon source of the carbon dots is rosmarinic acid.

Embodiment 2

[0057] Embodiment 2: A kind of method for preparing carbon dot

[0058] This example provides a method for preparing the carbon dots described in Example 1. The method is as follows: add 0.1 g of rosmarinic acid to 15 mL of deionized water to obtain a precursor solution; add 150 μL of ethylenediamine to the precursor solution to obtain a mixed solution; the use concentration is 0.01mol L -1 hydrochloric acid to adjust the pH of the mixed solution to 5 to obtain a reaction system; the reaction system was added to a high-temperature reactor, and calcined at 150°C for 8 hours to obtain a reaction solution containing carbon dots; the reaction solution containing carbon dots was naturally cooled to After room temperature (25°C), first filter with a filter membrane with a pore size of 0.22 μm to remove larger particles, then add the filtered filtrate to a dialysis bag (cut-off Mn=1.0kDa) for dialysis for 6 hours, and finally the dialysis obtained The dialysate was freeze-dried at -...

experiment example 1

[0059] Experimental example 1: Performance testing experiment of carbon dots

[0060] This experimental example provides the performance detection experiment of the carbon dot described in embodiment 1, and the experimental method and results are as follows:

[0061] Experiment 1: Dissolve 500 μg of carbon dots prepared in Example 2 in 10 mL of deionized water to obtain a carbon dot concentration of 0.05 mg·mL -1 The carbon dot stock solution; use the H-600 transmission electron microscope (FEI, the U.S.) to shoot the carbon dot stock solution, obtain the transmission electron microscope (TEM) photo of the carbon dot in the stock solution, see the photo figure 1 . From figure 1 It can be seen that the carbon dots in the stock solution are spherical, and the dispersion in water is very good.

[0062] Experiment 2: Take the carbon dot stock solution obtained in Experiment 1, and use a dynamic light scattering laser particle size analyzer (Malvern, UK) to detect the carbon dot...

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Abstract

The invention relates to a carbon dot taking rosmarinic acid as a carbon source as well as a preparation method and application of the carbon dot, and belongs to the technical field of nano materials. The invention provides a carbon dot which is a nitrogen-doped carbon dot taking rosmarinic acid as a carbon source, and the carbon dot has the following properties: good water solubility; the particle size is uniform; no biotoxicity exists; active oxygen can be effectively removed; the carbon dot can generate fluorescence weakening under the induction of hypochlorite ions, and the generated fluorescence weakening has a linear relationship with the concentration of the hypochlorite ions, so that the carbon dot has an extremely high application prospect in hypochlorite ion concentration detection and preparation of a product with an active oxygen removal effect. Moreover, the carbon dots have excellent photoluminescence properties, so that the carbon dots also have potential application prospects in the aspects of in-vivo ROS targeting and imaging, and therefore, the carbon dots have extremely high application prospects in hypochlorite ion concentration detection.

Description

technical field [0001] The invention relates to a carbon point using rosmarinic acid as a carbon source, a preparation method and application thereof, and belongs to the technical field of nanomaterials. Background technique [0002] Reactive oxygen species (ROS) are a type of 2 of free radicals. In the body, active oxygen is a very important substance, which can regulate a variety of physiological activities in the human body. For example, during the development of the embryo, it needs to be in a redox state for a period of time to undergo some changes. However, when the active oxygen is generated too much and the antioxidant mechanism in the body cannot balance it, the genetic material, such as DNA, protein and lipids on the membrane, will be oxidized and damaged. This behavior is also called oxidative stress (Oxidative Stress). Stress). Oxidative stress in the human body can lead to many diseases in the human body, including some very serious long-term degenerative dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00G01N21/64A61K8/19A61K49/00A61L15/18A61Q19/08
CPCC09K11/65B82Y20/00B82Y40/00G01N21/643A61L15/18A61L15/44A61K8/19A61Q19/08A61K49/0019
Inventor 李力梅茜董文飞葛明锋常智敏从瑛哥
Owner 苏州深得源健康科技有限公司
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