Nanometer material with surface inorganic metal ion mediated targeting effect and application thereof

Abstract

The invention discloses a nano-material with surface inorganic metal ion mediated targeting effect, the surface of the nano-material is provided with inorganic metal ions, and the inorganic metal ions can be specifically combined with specific receptor protein on a cell membrane; by regulating and controlling the content of inorganic metal ions on the surface of the nano-material and the exposure of the inorganic metal ions on the surface of the nano-material, the targeting property of the nano-material is optimized, so that the ions on the surface of the nano-material become active sites of the targeting effect and are selectively combined with ion transporters on the surface of a cell membrane; the targeting effect of ion mediation on the surface of the nano material is realized. The invention belongs to the technical field of targeted nanometer, and particularly relates to a nanometer material with a surface inorganic metal ion mediated targeting effect and application of the nanometer material.

Description

technical field [0001] The invention belongs to the field of targeted nanotechnology, in particular to a nanomaterial with surface inorganic metal ions mediated targeting and its application. Background technique [0002] Inorganic nanomaterials have the advantages of good biosafety, rich physical and chemical properties, large specific surface area, and easy surface functional modification. The constructed targeted nanoprobes are used in the diagnosis and treatment of tumors, cardiovascular and cerebrovascular diseases Shows broad application prospects. At present, the targeting of nanomaterials is mainly achieved by coupling ligand molecules such as antibodies, polypeptides, and nucleic acids with targeting functions on their surfaces to specifically bind to specific biomolecules to achieve targeting. Therefore, the specificity of the ligand is crucial for the targeting efficiency and therapeutic effect of nanoprobes. Improving the targeting efficiency of nanomaterials h...

AI Technical Summary

Problems solved by technology

[0003] Although the targeting effect can be achieved by modifying the surface of ligand molecules on nanomaterials, the existing ligand molecule-mediated targeting effects often make it difficult to effectively expose the target binding sites of ligand molecules due to non-directional coupling techniques. Insufficient availability of molecules during targeting, affecting their targeting efficiency

In recent years, with the development of the directional coupling technology of ligand molecules, the ligand targeting sites have been fully exposed, but the directional coupling technology is relatively complicated and the preparation cost is high, which limits its popularization and application.

[0004] Aiming at the problem of insufficient targeting efficiency in the biomedical application of nanomaterials, the present invention provides a nanomaterial with surface inorganic metal ion-mediated targeting, which is different from the targeting effect mediated by existing ligand molecules. The present invention utilizes The selective binding between the inorganic metal ion on the surface of the nanomaterial and the transport protein corresponding to the ion can be achieved by regulating the content of the inorganic metal ion in the nanomaterial and the exposure of the surface inorganic metal ion without modifying the targeting ligand. amount, achieving efficient targeting

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