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Artificial periosteum containing quercetin and magnesium oxide as well as preparation method and application of artificial periosteum

A technology of artificial bone and magnesium oxide, which is applied in the field of biomedical materials, can solve the problems of unsatisfactory angiogenesis, complicated preparation process, and high preparation cost, and achieve the effect of favorable differentiation and mineralization, simple operation, and good osteoinduction

Active Publication Date: 2022-06-03
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has good osteogenic activity, but its performance in angiogenesis is not satisfactory, and the preparation process is complicated and the preparation cost is high

Method used

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  • Artificial periosteum containing quercetin and magnesium oxide as well as preparation method and application of artificial periosteum
  • Artificial periosteum containing quercetin and magnesium oxide as well as preparation method and application of artificial periosteum
  • Artificial periosteum containing quercetin and magnesium oxide as well as preparation method and application of artificial periosteum

Examples

Experimental program
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Embodiment 1

[0036] The artificial periosteum obtained in this example contains 0.1% quercetin and 20% magnesium oxide nanoparticles.

Embodiment 2

[0038] The artificial periosteum obtained in this example contains 0.01% quercetin and 20% magnesium oxide nanoparticles.

Embodiment 1

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Abstract

The invention relates to the technical field of biomedical materials, and particularly discloses an artificial periosteum containing quercetin and magnesium oxide, and the artificial periosteum is a nanofiber membrane containing magnesium oxide nanoparticles and quercetin. The invention also discloses a preparation method of the artificial periosteum, which comprises the following steps: 1) dissolving the degradable high polymer material, the magnesium oxide nanoparticles and the quercetin in an organic solution, and stirring and dissolving at room temperature to obtain an electrostatic spinning solution; and 2) preparing the artificial periosteum from the electrostatic spinning solution through an electrostatic spinning method. The invention further discloses application of the artificial periosteum to preparation of a periosteum tissue repair material. The artificial periosteum prepared by the invention has the effects of promoting cell migration, osteogenesis and angiogenesis, can accelerate bone regeneration in a bone defect area, can induce cell adhesion, proliferation, differentiation and mineralization, is beneficial to local neovascularization, and can better meet clinical requirements.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an artificial periosteum containing quercetin and magnesium oxide, a preparation method and an application. Background technique [0002] Periosteum is a highly vascularized dense connective tissue membrane covering the surface of bone tissue, which is crucial in bone development and fracture healing, providing cellular and nutritional support for new bone formation and promoting rapid bone regeneration. In the treatment of segmental bone defects, timely and abundant vascular ingrowth is one of the prerequisites for a good prognosis. Nonunion or delayed healing is the most common sequela of segmental bone defects, usually associated with periosteal dissection or Injury-related, retaining the periosteum or using a periosteal graft can significantly improve the osseointegration of the bone graft and accelerate the process of bone defect reconstruction. [0003] In the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/02A61L27/18A61L27/58D01F6/92D01F1/10D04H1/728D04H1/4382
CPCA61L27/54A61L27/025A61L27/58A61L27/18D01F6/92D01F1/10D04H1/728D04H1/43838A61L2400/12A61L2300/102A61L2300/624A61L2300/604A61L2300/216A61L2300/412A61L2300/45A61L2430/02
Inventor 贺曦刘彦伶刘文斌
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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