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Suspension gel for treating inflammatory dermatosis

An inflammatory skin disease and gel technology, applied in the field of medicinal chemistry, can solve the problems of chemical stability risk of maxacalcitol, thermal instability of maxacalcitol, and poor compliance of patients with medication, etc. Effects of tack and elasticity, easy spread and wash off, excellent physical and chemical stability

Pending Publication Date: 2022-06-07
NANJING HERON PHARMA SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the ointment preparation has the following problems: the waxy base in the prescription is relatively oily, and there will be a greasy film on the skin after use, which is difficult to clean, and the patient's medication compliance is poor
In addition, the temperature of the waxy carrier needs to be maintained at a high temperature (nearly 70°C) during the preparation process, and maxacalcitol is unstable to heat, which brings risks to the chemical stability of maxacalcitol to a certain extent

Method used

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  • Suspension gel for treating inflammatory dermatosis
  • Suspension gel for treating inflammatory dermatosis
  • Suspension gel for treating inflammatory dermatosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] This embodiment provides a suspension gel, the total mass of the suspension gel is 500g, and the raw and auxiliary materials for the preparation of the suspension gel include the following components in terms of mass percentage:

[0104]

[0105] The preparation method of the suspension gel comprises the following steps:

[0106] (1) Dissolve maxacalcitol in the mixed solvent of caprylic acid capric triglyceride, isopropyl myristate, light liquid paraffin and diethylene glycol monoethyl ether according to the recipe quantity, then add dibutyl Hydroxytoluene, dl-α-tocopherol, Span 80 and polyoxyethylene-35 castor oil were mixed at 25°C for 2h to obtain an oil phase;

[0107] (2) mix Poloxamer 188 and purified water at 25°C for 0.5h according to the recipe to obtain an aqueous phase;

[0108] (3) Disperse Carbomer Tr-1 in water according to the recipe quantity, add triethylamine alcohol to adjust pH to 6.0 after complete swelling, and mix for 8h to obtain a gel phase;...

Embodiment 2

[0111] This embodiment provides a suspension gel, the total mass of the suspension gel is 1000g, and the preparation raw and auxiliary materials of the suspension gel include the following components in terms of mass percentage:

[0112]

[0113] The preparation method of the suspension gel comprises the following steps:

[0114] (1) Dissolve maxacalcitol in the mixed solvent of caprylic acid capric triglyceride, isopropyl myristate, light liquid paraffin and diethylene glycol monoethyl ether according to the recipe quantity, then add dibutyl Hydroxytoluene, dl-α-tocopherol, Span 80 and polyoxyethylene-35 castor oil were mixed at 25°C for 2h to obtain an oil phase;

[0115] (2) mix Poloxamer 188 and purified water at 25°C for 0.5h according to the recipe to obtain an aqueous phase;

[0116] (3) Disperse Carbomer Tr-1 in water according to the recipe quantity, add triethylamine alcohol to adjust pH to 6.0 after complete swelling, and mix for 8h to obtain a gel phase;

[01...

Embodiment 3

[0119] This embodiment provides a suspension gel, the total mass of the suspension gel is 1000g, and the preparation raw and auxiliary materials of the suspension gel include the following components in terms of mass percentage:

[0120]

[0121] The preparation method of the suspension gel comprises the following steps:

[0122] (1) Dissolve maxacalcitol in the mixed solvent of caprylic acid capric triglyceride, isopropyl myristate, light liquid paraffin and diethylene glycol monoethyl ether according to the recipe quantity, then add dibutyl Hydroxytoluene, dl-α-tocopherol, Span 80 and polyoxyethylene-35 castor oil were mixed at 25°C for 2h to obtain an oil phase;

[0123] (2) mix Poloxamer 188 and purified water at 25°C for 0.5h according to the recipe to obtain an aqueous phase;

[0124] (3) Disperse Carbomer Tr-1 in water according to the recipe quantity, add sodium hydroxide to adjust pH to 6.0 after complete swelling, and mix for 8h to obtain a gel phase;

[0125] (...

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Abstract

The invention provides a suspension gel for treating inflammatory dermatosis, the suspension gel comprises an oil phase component, a water phase component and a gel phase component, the oil phase component comprises an active component and an antioxidant; wherein the active ingredient is maxacalcitol, and the antioxidant comprises any one or a combination of at least two of butylated hydroxyanisole, propyl gallate, dl-alpha-tocopherol and butylated hydroxytoluene. The suspension gel provided by the invention has proper viscosity and elasticity, does not irritate the skin, is not greasy, is easy to spread and wash off, does not pollute clothes, and can be directly applied to the skin; the suspension gel provided by the invention has excellent physical stability and chemical stability; the suspension gel provided by the invention can improve absorption of maxacalcitol by skin.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, in particular to a suspension gel for treating inflammatory skin diseases. Background technique [0002] Chronic inflammatory skin diseases, especially psoriasis, are not uncommon, affecting about 2% of the world's population, with about one third of patients developing before the age of 18. It is generally believed that psoriasis is an "autoimmune system disorder". Although it does not directly affect life, it has a direct impact on physical and mental health. [0003] Maxacalcidol is a vitamin D 3 The derivative, maxacalcitol ointment, was developed and marketed by Maruho Company in Japan in 2006. It is mainly used for the treatment of psoriasis, ichthyosis, palmoplantar keratosis, palmoplantar pus disease, etc. The prescription composition includes absolute ethanol , medium chain triglycerides and white petrolatum. [0004] However, the ointment preparation has the following problems: the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/593A61K47/10A61K47/14A61K47/22A61K47/44A61P17/00A61P37/02A61P17/06
CPCA61K9/06A61K31/593A61K47/10A61K47/14A61K47/22A61K47/44A61P17/00A61P37/02A61P17/06
Inventor 苗娜娜张德宇王雪萌王林胡永康王隽周文亮
Owner NANJING HERON PHARMA SCI & TECH CO LTD
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