Compound double-layer tablet containing ritonavir pellets for treating novel coronavirus
A double-layer tablet, coronavirus technology, applied in the directions of antiviral agents, medical preparations containing active ingredients, pill delivery, etc., can solve the problems of high production cost, long process time, cumbersome production process, etc., and achieve production cost. Low, good drug compliance, simple production process effect
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Embodiment 1
[0050] Ritonavir layer:
[0051]
[0052] Its preparation method is:
[0053](1) After mixing the ritonavir of the recipe with the copovidone of the recipe, Span 20, and colloidal silicon dioxide, add it to the hot-melt extruder. The hot-melt extrusion temperature is 100-120°C for hot-melt extrusion to prepare a solid dispersion;
[0054] (2) After the solid dispersion is pulverized by a high-efficiency pulverizer, the particle size range is controlled to be 0.5 to 1 mm;
[0055] (3) After pulverization, the granules are coated, and a coating solution with a concentration of 15% is prepared. The granules are put into a fluidized bed granulation pot, preheated, and when the temperature of the material reaches 40 °C, spray slurry to control the temperature of the material to be about 40 °C. , the flow rate of the coating liquid is 50g / min, and the surface of the particles is coated with a gastrosoluble coating film. Finally, pellets containing ritonavir were obtained.
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Embodiment 2
[0068] Ritonavir layer:
[0069]
[0070] Its preparation method is
[0071] (1) add the hot melt extruder after mixing the ritonavir of the recipe quantity and the polyvinylpyrrolidone of the recipe quantity, sodium lauryl sulfate, talc. The hot-melt extrusion temperature is 100-120°C for hot-melt extrusion to prepare a solid dispersion;
[0072] (2) After the solid dispersion is pulverized by a high-efficiency pulverizer, the particle size range is controlled to be 0.5 to 1 mm;
[0073] (3) After pulverization, the granules are coated, and a coating solution with a concentration of 15% is prepared. The granules are put into a fluidized bed granulation pot, preheated, and when the temperature of the material reaches 40 °C, spray slurry to control the temperature of the material to be about 40 °C. , the flow rate of the coating liquid is 50g / min, and the surface of the particles is coated with a gastrosoluble coating film. Finally, pellets containing ritonavir were obtai...
Embodiment 3
[0085] Ritonavir layer:
[0086]
[0087] Its preparation method is:
[0088] (1) after the ritonavir of recipe quantity and the copovidone of recipe quantity, sodium lauryl sulfate, colloidal silicon dioxide are mixed and dissolved in methylene chloride, fluidized bed granulator is turned on hot air 80 ℃ , spray drying to prepare granules;
[0089] (2) The spray-dried granules are screened by a lifting dry granulator, and the screen aperture is 0.6 mm;
[0090] (3) Coat the granulated granules, prepare a coating solution with a concentration of 15%, put the granules into the fluidized bed granulation pot, preheat, when the temperature of the material reaches 40 °C, spray slurry, and control the temperature of the material to be about 40 °C , the flow rate of the coating liquid is 50g / min, and the surface of the particles is coated with a gastrosoluble coating film. Finally, pellets containing ritonavir were obtained.
[0091] (4) Mix the pellets with lactose and steari...
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