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Traditional Chinese medicine extract composition for preventing and treating influenza as well as preparation method and application of traditional Chinese medicine extract composition

A composition and extract technology, applied in the field of medicine, can solve problems such as leukopenia, hemolytic anemia, myocardial damage, pancreatitis, unsatisfactory patient curative effect, and limited benefit population, and achieve good quality controllability and disease The effect of reducing the degree and accelerating the mass transfer speed

Active Publication Date: 2022-07-05
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, some western medicines are commonly used to prevent and treat influenza virus. Western medicine is mainly symptomatic treatment, one component is aimed at one symptom, and western medicine often has some side effects. For example, oseltamivir can convert the esterase in the intestinal tract into active metabolites, thereby Interfering with the spread of the virus, but not suitable for patients who have symptoms of lower respiratory tract infection; Peramivir, as the only intravenous neuraminidase inhibitor, is more effective than other neuraminidase inhibitors, and is more effective than oral neuraminidase inhibitors. Oseltamivir can shorten the time of fever more effectively, but it may be mutually resistant with other neuraminidase inhibitors, and the efficacy of oseltamivir-resistant patients is not satisfactory; the use of ribavirin will cause nausea Vomiting, fatigue, headache, fatigue, chest tightness, fever, chills and other adverse reactions. In severe cases, leukopenia, hemolytic anemia, myocardial damage, pancreatitis and other symptoms may occur
[0004] However, traditional Chinese medicine can comprehensively treat colds through the overall regulation of human body functions. It has a unique curative effect in preventing and treating influenza, and generally does not have side effects.

Method used

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  • Traditional Chinese medicine extract composition for preventing and treating influenza as well as preparation method and application of traditional Chinese medicine extract composition
  • Traditional Chinese medicine extract composition for preventing and treating influenza as well as preparation method and application of traditional Chinese medicine extract composition
  • Traditional Chinese medicine extract composition for preventing and treating influenza as well as preparation method and application of traditional Chinese medicine extract composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 Chinese medicine extract composition preparation 2.0 native medicine g / kg

[0041] Preparation of Angelica extract: Take 1kg of Angelica medicinal material, crush it and pass through a 40-mesh sieve, put it into a subcritical fluid extraction tank (CBE-2×25L), add butane, and extract 3 times at 45°C for 35 minutes. , separate the extractant, recover the volatile oil of Angelica sinensis, and detect that the mass content of ferulic acid is greater than or equal to 1.0%, and the mass content of ligustilide is greater than or equal to 30%;

[0042] Preparation of Chuanxiong extract: The dried Chuanxiong whole medicinal materials were pulverized with a pulverizer and passed through a 40-mesh sieve, weighed 1kg, put it into a subcritical fluid extraction tank (CBE-2×25L), added butane, and heated it at 35°C. , extract for 55min, extract 3 times, separate the extractant, recover the volatile oil of Ligusticum chuanxiong, detect its ligustilide content not less th...

Embodiment 2

[0046] Embodiment 2 Chinese medicine extract composition preparation 4.0 native medicine g / kg

[0047]Preparation of Angelica extract: Take 1kg of Angelica medicinal material, crush it and pass through a 40-mesh sieve, put it into a subcritical fluid extraction tank (CBE-2×25L), add butane, extract at 35°C for 45min, and extract twice , separate the extractant, recover the volatile oil of Angelica sinensis, and detect that the mass content of its ferulic acid is greater than or equal to 1%, and the mass content of ligustilide is greater than or equal to 35%;

[0048] Preparation of Chuanxiong extract: The dried Chuanxiong whole medicinal materials were pulverized with a pulverizer and passed through a 40-mesh sieve, weighed 1kg, put it into a subcritical fluid extraction tank (CBE-2×25L), added butane, and heated at 45°C. , extract 45min, extract 2 times, separate the extractant, recover the volatile oil of Ligusticum chuanxiong, detect its ligustilide content not less than 12...

Embodiment 3

[0052] Embodiment 3 Chinese medicine extract composition preparation 8.0 native medicine g / kg

[0053] Preparation of Angelica sinensis extract: take 2kg of Angelica sinensis medicinal materials, pulverize and pass through a 40 mesh sieve, put it into a subcritical fluid extraction tank (CBE-2×25L), add butane, and extract at 35°C for 45min and twice. , separate the extractant, recover the volatile oil of Angelica sinensis, and detect that the mass content of its ferulic acid is greater than or equal to 1%, and the mass content of ligustilide is greater than or equal to 35%;

[0054] Preparation of Chuanxiong extract: The dried Chuanxiong whole medicinal materials were pulverized with a pulverizer and passed through a 40-mesh sieve, weighed 2kg, put it into a subcritical fluid extraction tank (CBE-2×25L), added butane, and heated it at 45°C. , extract for 45min, extract twice, separate the extractant, recover the volatile oil of Ligusticum chuanxiong, detect that the content o...

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Abstract

The invention discloses a traditional Chinese medicine extract composition for preventing and treating influenza. The traditional Chinese medicine extract composition comprises the following components: an angelica sinensis extract, a ligusticum wallichii extract and pharmaceutically acceptable auxiliary materials, the Chinese angelica extract and the Ligusticum wallichii extract are combined to achieve a good treatment effect on diseases caused by influenza viruses, and the traditional Chinese medicine extract composition for preventing and treating influenza can remarkably prolong the lifetime of mice with influenza viruses and reduce the death rate of the mice with influenza viruses; meanwhile, the lung index of an influenza virus mouse can be remarkably reduced, and lung injury caused by the influenza virus can be effectively inhibited.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine extract composition for preventing and treating influenza and a preparation method and application thereof. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus, with high incidence in spring and autumn, and high incidence in the Asia-Pacific region. In high-risk groups such as children, pregnant women, the elderly, and immunodeficiency groups, influenza virus can cause lung damage and induce severe disease. Viral pneumonia, leading to multiple organ failure or worsening of underlying diseases, or even death. [0003] At present, some Western medicines are commonly used to prevent and treat influenza virus. Western medicines are mainly symptomatic treatment. One ingredient is for one symptom, and Western medicines often have some side effects. For example, oseltamivir can convert esterases in the intest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61P31/16A61P11/00
CPCA61K36/232A61K36/236A61P31/16A61P11/00A61K2236/37A61K2300/00Y02P20/54
Inventor 谭正怀邸多隆熊静悦裴栋
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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