Application of PAYCS in regulation of intestinal flora, metabolite and cranial neurotransmitter

Abstract

The invention belongs to the technical field of health food, and discloses an application of PAYCS in regulating intestinal flora, metabolites and cranial neurotransmitters, and PAYCS is used for rescuing scopolamine-induced mouse dysmnesia by improving oxidation and inflammatory stress and regulating intestinal microorganism-metabolite-cranial neurotransmitter axis. The PAYCS can significantly reduce serum MDA and LDH levels and significantly increase the SOD content of the liver through a channel for improving memory through intestinal microorganisms-metabolites and neurotransmitter axes; the PAYCS-H can inhibit the rise of TNF-alpha (tumor necrosis factor-alpha) and IL-1beta (interleukin-1beta) of the liver, and the PAYCS-L can only reduce the content of the TNF-alpha of the liver; therefore, the PAYCS-L changes the ratio of bacteroides / bacteroides, the PAYCS improves the relative abundance of plants such as the cactaceae, the prevotella and the like, and tryptophan metabolism related neurotransmitters in the brain are improved.

Description

technical field [0001] The invention belongs to the technical field of health food, and particularly relates to the application of PAYCS in regulating intestinal flora, metabolites and brain neurotransmitters. Background technique [0002] At present, the gut-brain axis is a two-way information exchange system that integrates the functions of the brain and the gut, and the two-way interaction between the central nervous system, the enteric nervous system and the gastrointestinal tract is also receiving increasing attention. Gut microbes participate in the functional response of the gut-brain axis and play a very important role in the communication between the gut and the brain. Therefore, medical scientists have proposed "The Brain-Gut-Microbiome Axis". the concept of. Changes in gut-brain axis function are involved in the occurrence of various gastrointestinal diseases, such as irritable bowel syndrome and related functional gastrointestinal diseases; recent studies have a...

AI Technical Summary

Problems solved by technology

[0005] The difficulty in solving the above problems and defects is: Alzheimer’s disease has complex causes of memory loss. Most nutritional supplements are researched from the perspective of anti-oxidation, but fail to deeply explore the relationship between memory loss and intestinal flora, metabolism and nerves. The relationship between transmitters

In the research, most of the plant extracts have a better effect of improving memory, but the preparation process of plant extracts is complicated, and the cost of introducing organic reagents is high

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